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Referencias:

• Schiene-Fischer, C., Multidomain Peptidyl Prolyl cis/trans Isomerases (2015) Biochim. Biophys. Acta, 1850, pp. 2005-2016
• Kang, C.B., Hong, Y., Dhe-Paganon, S., Yoon, H.S., FKBP family proteins: Immunophilins with versatile biological functions (2008) Neurosignals, 16, pp. 318-325
• Kino, T., Hatanaka, H., Miyata, S., Inamura, N., Nishiyama, M., Yajima, T., Goto, T., Aoki, H., FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro (1987) J. Antibiot., 40, pp. 1256-1265
• Kino, T., Hatanaka, H., Hashimoto, M., Nishiyama, M., Goto, T., Okuhara, M., Kohsaka, M., Imanaka, H., FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics (1987) J. Antibiot., 40, pp. 1249-1255
• Ruegger, A., Kuhn, M., Lichti, H., Loosli, H.R., Huguenin, R., Quiquerez, C., von Wartburg, A., Cyclosporin, A., A Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity (1976) Helv. Chim. Acta, 59, pp. 1075-1092
• Ciclosporin Drug Discovery—A History; John Wiley & Sons, p. 2005. , New York, NY, USA
• Hanes, S.D., Prolyl isomerases in gene transcription (2015) Biochim. Biophys. Acta, 1850, pp. 2017-2034
• Matena, A., Rehic, E., Honig, D., Kamba, B., Bayer, P., Structure and function of the human parvulins Pin1 and Par14/17 (2018) Biol. Chem., 399, pp. 101-125
• Barik, S., Dual-Family Peptidylprolyl Isomerases (Immunophilins) of Select Monocellular Organisms (2018) Biomolecules, 8
• Netzer, W.J., Hartl, F.U., Recombination of protein domains facilitated by co-translational folding in eukaryotes (1997) Nature, 388, pp. 343-349
• Helbig, S., Patzer, S.I., Schiene-Fischer, C., Zeth, K., Braun, V., Activation of colicin M by the FkpA prolyl cis-trans isomerase/chaperone (2011) J. Biol. Chem., 286, pp. 6280-6290
• Theuerkorn, M., Fischer, G., Schiene-Fischer, C., Prolyl cis/trans isomerase signalling pathways in cancer (2011) Curr. Opin. Pharmacol., 11, pp. 281-287
• Li, Z.W., Zhang, J., Ouyang, C.H., Li, C.Y., Zhao, F.B., Liu, Y.W., Ai, Y.X., Hu, W.P., Potentiation by WIN 55,212-2 of GABA-activated currents in rat trigeminal ganglion neurones (2009) Br. J. Pharmacol., 158, pp. 1904-1910
• Li, H., Rao, A., Hogan, P.G., Interaction of calcineurin with substrates and targeting proteins (2011) Trends Cell Biol, 21, pp. 91-103
• Callebaut, I., Renoir, J.M., Lebeau, M.C., Massol, N., Burny, A., Baulieu, E.E., Mornon, J.P., An immunophilin that binds M(R) 90,000 heat shock protein: Main structural features of a mammalian p59 protein (1992) Proc. Natl. Acad. Sci. USA, 89, pp. 6270-6274
• Smith, D.F., Tetratricopeptide repeat cochaperones in steroid receptor complexes (2004) Cell Stress Chaperones, 9, pp. 109-121
• Miyata, Y., Chambraud, B., Radanyi, C., Leclerc, J., Lebeau, M.C., Renoir, J.M., Shirai, R., Baulieu, E.E., Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: Regulation of HSP90-binding activity of FKBP52 (1997) Proc. Natl. Acad. Sci. USA, 94
• Wochnik, G.M., Ruegg, J., Abel, G.A., Schmidt, U., Holsboer, F., Rein, T., FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells (2005) J. Biol. Chem., 280, pp. 4609-4616
• Riggs, D.L., Cox, M.B., Cheung-Flynn, J., Prapapanich, V., Carrigan, P.E., Smith, D.F., Functional specificity of co-chaperone interactions with Hsp90 client proteins (2004) Crit. Rev. Biochem. Mol. Biol., 39, pp. 279-295
• Fries, G.R., Gassen, N.C., Rein, T., The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease (2017) Int. J. Mol. Sci., 18, p. 2614
• Cauerrhff, A.A., Galigniana, M.D., Structural characteristics of the TPR protein-Hsp90 interaction: A new target in biotechnology. In Role of Molecular Chaperones in Structural Folding, Biological Actions, and Drug Interactions of Client Proteins; Galigniana, M.D., Ed.; Bentham Science Publishers: Emirate of Sharjah (2018) United Arab Emirates, 1, pp. 73-173. , Volume, pp
• Lemaster, D.M., Mustafi, S.M., Brecher, M., Zhang, J., Heroux, A., Li, H., Hernandez, G., Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins (2015) J. Biol. Chem., 290, pp. 15746-15757
• Schopf, F.H., Biebl, M.M., Buchner, J., The HSP90 chaperone machinery (2017) Nat. Rev. Mol. Cell Biol., 18, pp. 345-360
• Storer, C.L., Dickey, C.A., Galigniana, M.D., Rein, T., Cox, M.B., FKBP51 and FKBP52 in signaling and disease (2011) Trends Endocrinol. Metab., 22, pp. 481-490
• Sinars, C.R., Cheung-Flynn, J., Rimerman, R.A., Scammell, J.G., Smith, D.F., Clardy, J., Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 868-873
• Wu, B., Li, P., Liu, Y., Lou, Z., Ding, Y., Shu, C., Ye, S., Rao, Z., 3D structure of human FK506-binding protein 52: Implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex (2004) Proc. Natl. Acad. Sci. USA, 101, pp. 8348-8353
• Guy, N.C., Garcia, Y.A., Sivils, J.C., Galigniana, M.D., Cox, M.B., Functions of the Hsp90-binding FKBP immunophilins (2015) Subcell. Biochem., 78, pp. 35-68
• Sivils, J.C., Storer, C.L., Galigniana, M.D., Cox, M.B., Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52) (2011) Curr. Opin. Pharmacol., 11, pp. 314-319
• de Leon, J.T., Iwai, A., Feau, C., Garcia, Y., Balsiger, H.A., Storer, C.L., Suro, R.M., Kim, Y.S., Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells (2011) Proc. Natl. Acad. Sci. USA, 108, pp. 11878-11883
• Mazaira, G.I., Daneri-Becerra, C., Zgajnar, N.R., Lotufo, C.M., Galigniana, M.D., Gene expression regulation by heat-shock proteins: The cardinal roles of HSF1 and Hsp90 (2018) Biochem. Soc. Trans., 46, pp. 51-65
• J. Mol. Biol. 2001; Pratt, W.B., The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase (1997) Annu. Rev. Pharm. Toxicol., 37, pp. 297-326
• Mazaira, G.I., Zgajnar, N.R., Lotufo, C.M., Daneri-Becerra, C., Sivils, J.C., Soto, O.B., Cox, M.B., Galigniana, M.D., The Nuclear Receptor Field: A Historical Overview and Future Challenges (2018) Nucl. Recept. Res., 5
• Pratt, W.B., Toft, D.O., Steroid receptor interactions with heat shock protein and immunophilin chaperones (1997) Endocr. Rev., 18, pp. 306-360
• Auricchio, F., Phosphorylation of steroid receptors (1989) J. Steroid Biochem., 32, pp. 613-622
• Galigniana, M.D., Native rat kidney mineralocorticoid receptor is a phosphoprotein whose transformation to a DNA-binding form is induced by phosphatases (1998) Biochem. J., 333, pp. 555-563
• McGuinness, D., McEwan, I.J., Posttranslational Modifications of Steroid Receptors: Phosphorylation (2016) Methods Mol. Biol., 1443, pp. 105-117
• Harrell, J.M., Kurek, I., Breiman, A., Radanyi, C., Renoir, J.M., Pratt, W.B., Galigniana, M.D., All of the protein interactions that link steroid receptor.Hsp90.immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells (2002) Biochemistry, 41, pp. 5581-5587
• Pratt, W.B., Krishna, P., Olsen, L.J., Hsp90-binding immunophilins in plants: The protein movers (2001) Trends Plant Sci, 6, pp. 54-58
• Erlejman, A.G., Lagadari, M., Toneatto, J., Piwien-Pilipuk, G., Galigniana, M.D., Regulatory role of the 90-kDa-heat-shock protein (Hsp90) and associated factors on gene expression (2014) Biochim. Biophys. Acta, 1839, pp. 71-87
• Galigniana, M.D., Radanyi, C., Renoir, J.M., Housley, P.R., Pratt, W.B., Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus (2001) J. Biol. Chem., 276, pp. 14884-14889
• Galigniana, M.D., Erlejman, A.G., Monte, M., Gomez-Sanchez, C., Piwien-Pilipuk, G., The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events (2010) Mol. Cell. Biol., 30, pp. 1285-1298
• Darshan, M.S., Loftus, M.S., Thadani-Mulero, M., Levy, B.P., Escuin, D., Zhou, X.K., Gjyrezi, A., Tagawa, S.T., Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer (2011) Cancer Res, 71, pp. 6019-6029
• Pratt, W.B., Galigniana, M.D., Harrell, J.M., Defranco, D.B., Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement (2004) Cell Signal, 16, pp. 857-872
• Yang, J., Liu, J., Defranco, D.B., Subnuclear trafficking of glucocorticoid receptors in vitro: Chromatin recycling and nuclear export (1997) J. Cell Biol., 137, pp. 523-538
• Fu, X., Liang, C., Li, F., Wang, L., Wu, X., Lu, A., Xiao, G., Zhang, G., The Rules and Functions of Nucleocytoplasmic Shuttling Proteins (2018) Int. J. Mol. Sci., 19, p. 1445
• Mazaira, G.I., Lagadari, M., Erlejman, A.G., Galigniana, M.D., The Emerging Role of TPR-Domain Immunophilins in the Mechanism of Action of Steroid Receptors (2014) Nucl. Recept. Res., 1, pp. 1-17
• Echeverria, P.C., Mazaira, G., Erlejman, A., Gomez-Sanchez, C., Piwien Pilipuk, G., Galigniana, M.D., Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta (2009) Mol. Cell. Biol., 29, pp. 4788-4797
• Presman, D.M., Alvarez, L.D., Levi, V., Eduardo, S., Digman, M.A., Marti, M.A., Veleiro, A.S., Pecci, A., Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids (2010) Plos ONE, 5
• Grossmann, C., Ruhs, S., Langenbruch, L., Mildenberger, S., Stratz, N., Schumann, K., Gekle, M., Nuclear shuttling precedes dimerization in mineralocorticoid receptor signaling (2012) Chem. Biol., 19, pp. 742-751
• Silverstein, A.M., Galigniana, M.D., Chen, M.S., Owens-Grillo, J.K., Chinkers, M., Pratt, W.B., Protein phosphatase 5 is a major component of glucocorticoid receptor.Hsp90 complexes with properties of an FK506-binding immunophilin (1997) J. Biol. Chem., 272, pp. 16224-16230
• Davies, T.H., Ning, Y.M., Sanchez, E.R., A new first step in activation of steroid receptors: Hormone-induced switching of FKBP51 and FKBP52 immunophilins (2002) J. Biol. Chem., 277, pp. 4597-4600
• Madan, A.P., Defranco, D.B., Bidirectional transport of glucocorticoid receptors across the nuclear envelope (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 3588-3592
• Galigniana, M.D., Echeverria, P.C., Erlejman, A.G., Piwien-Pilipuk, G., Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore (2010) Nucleus, 1, pp. 299-308
• Galigniana, M.D., Steroid receptor coupling becomes nuclear (2012) Chem. Biol., 19, pp. 662-663
• Gallo, L.I., Ghini, A.A., Piwien Pilipuk, G., Galigniana, M.D., Differential recruitment of tetratricorpeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity (2007) Biochemistry, 46
• Erlejman, A.G., Lagadari, M., Harris, D.C., Cox, M.B., Galigniana, M.D., Molecular chaperone activity and biological regulatory actions of the TPR-domain immunophilins FKBP51 and FKBP52 (2014) Curr. Protein Pept. Sci., 15, pp. 205-215
• Ratajczak, T., Cluning, C., Ward, B.K., Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling (2015) Clin. Biochem. Rev., 36, pp. 31-52
• Oroz, J., Chang, B.J., Wysoczanski, P., Lee, C.T., Perez-Lara, A., Chakraborty, P., Hofele, R.V., Biernat, J., Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex (2018) Nat. Commun., 9
• Cluning, C., Ward, B.K., Rea, S.L., Arulpragasam, A., Fuller, P.J., Ratajczak, T., The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones (2013) Mol. Endocrinol., 27, pp. 1020-1035
• Sabbagh, J.J., Cordova, R.A., Zheng, D., Criado-Marrero, M., Lemus, A., Li, P., Baker, J.D., Martinez-Licha, C., Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD (2018) ACS Chem. Biol., 13, pp. 2288-2299
• Echeverria, P.C., Picard, D., Molecular chaperones, essential partners of steroid hormone receptors for activity and mobility (2010) Biochim. Biophys. Acta, 1803, pp. 641-649
• Ebong, I.O., Beilsten-Edmands, V., Patel, N.A., Morgner, N., Robinson, C.V., The interchange of immunophilins leads to parallel pathways and different intermediates in the assembly of Hsp90 glucocorticoid receptor complexes (2016) Cell Discov, 2
• Vandevyver, S., Dejager, L., Libert, C., On the trail of the glucocorticoid receptor: Into the nucleus and back (2012) Traffic, 13, pp. 364-374
• Tatro, E.T., Everall, I.P., Kaul, M., Achim, C.L., Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder (2009) Brain Res, 1286, pp. 1-12
• Jeong, Y.Y., Her, J., Oh, S.Y., Chung, I.K., Hsp90-binding immunophilin FKBP52 modulates telomerase activity by promoting the cytoplasmic retrotransport of hTERT (2016) Biochem. J., 473, pp. 3517-3532
• Vafopoulou, X., Steel, C.G., Cytoplasmic travels of the ecdysteroid receptor in target cells: Pathways for both genomic and non-genomic actions (2012) Front. Endocrinol., 3
• Schuster, M., Schnell, L., Feigl, P., Birkhofer, C., Mohr, K., Roeder, M., Carle, S., Buchner, J., The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells (2017) Sci. Rep., 7
• Erlejman, A.G., de Leo, S.A., Mazaira, G.I., Molinari, A.M., Camisay, M.F., Fontana, V., Cox, M.B., Galigniana, M.D., NF-κB transcriptional activity is modulated by FK506-binding proteins FKBP51 and FKBP52: A role for peptidyl-prolyl isomerase activity (2014) J. Biol. Chem., 289, pp. 26263-26276
• Galigniana, M.D., Harrell, J.M., O'hagen, H.M., Ljungman, M., Pratt, W.B., Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus (2004) J. Biol. Chem., 279, pp. 22483-22489
• Colo, G.P., Rubio, M.F., Nojek, I.M., Werbajh, S.E., Echeverria, P.C., Alvarado, C.V., Nahmod, V.E., Costas, M.A., The p160 nuclear receptor co-activator RAC3 exerts an anti-apoptotic role through a cytoplasmatic action (2008) Oncogene, 27, pp. 2430-2444
• Lagadari, M., Zgajnar, N.R., Gallo, L.I., Galigniana, M.D., Hsp90-binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity (2016) Mol. Oncol., 10, pp. 1086-1098
• McKeen, H.D., McAlpine, K., Valentine, A., Quinn, D.J., McClelland, K., Byrne, C., O'rourke, M., McCarthy, H.O., A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling (2008) Endocrinology, 149, pp. 5724-5734
• Nair, S.C., Rimerman, R.A., Toran, E.J., Chen, S., Prapapanich, V., Butts, R.N., Smith, D.F., Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor (1997) Mol. Cell. Biol., 17, pp. 594-603
• Barent, R.L., Nair, S.C., Carr, D.C., Ruan, Y., Rimerman, R.A., Fulton, J., Zhang, Y., Smith, D.F., Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes (1998) Mol. Endocrinol., 12, pp. 342-354
• Ratajczak, T., Hlaing, J., Brockway, M.J., Hahnel, R., Isolation of untransformed bovine estrogen receptor without molybdate stabilization (1990) J. Steroid Biochem., 35, pp. 543-553
• Thadani-Mulero, M., Portella, L., Sun, S., Sung, M., Matov, A., Vessella, R.L., Corey, E., Giannakakou, P., Androgen receptor splice variants determine taxane sensitivity in prostate cancer (2014) Cancer Res, 74, pp. 2270-2282
• Pratt, W.B., Czar, M.J., Stancato, L.F., Owens, J.K., The hsp56 immunophilin component of steroid receptor heterocomplexes: Could this be the elusive nuclear localization signal-binding protein? (1993) J. Steroid Biochem. Mol. Biol., 46, pp. 269-279
• Jhaveri, K., Ochiana, S.O., Dunphy, M.P., Gerecitano, J.F., Corben, A.D., Peter, R.I., Janjigian, Y.Y., Modi, S., Heat shock protein 90 inhibitors in the treatment of cancer: Current status and future directions (2014) Expert Opin. Investig. Drugs, 23, pp. 611-628
• Chatterjee, S., Burns, T.F., Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach (2017) Int. J. Mol. Sci., 18, p. 1978
• Inda, C., Bolaender, A., Wang, T., Gandu, S.R., Koren, J., Stressing Out Hsp90 in Neurotoxic Proteinopathies (2016) Curr. Top. Med. Chem., 16, pp. 2829-2838
• Reynolds, P.D., Ruan, Y., Smith, D.F., Scammell, J.G., Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51 (1999) J. Clin. Endocrinol. Metab., 84, pp. 663-669
• Denny, W.B., Valentine, D.L., Reynolds, P.D., Smith, D.F., Scammell, J.G., Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding (2000) Endocrinology, 141, pp. 4107-4113
• Westberry, J.M., Sadosky, P.W., Hubler, T.R., Gross, K.L., Scammell, J.G., Glucocorticoid resistance in squirrel monkeys results from a combination of a transcriptionally incompetent glucocorticoid receptor and overexpression of the glucocorticoid receptor co-chaperone FKBP51 (2006) J. Steroid Biochem. Mol. Biol., 100, pp. 34-41
• Binder, E.B., Salyakina, D., Lichtner, P., Wochnik, G.M., Ising, M., Putz, B., Papiol, S., Kohli, M.A., Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment (2004) Nat. Genet., 36, pp. 1319-1325
• Riggs, D.L., Roberts, P.J., Chirillo, S.C., Cheung-Flynn, J., Prapapanich, V., Ratajczak, T., Gaber, R., Smith, D.F., The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo (2003) EMBO J, 22, pp. 1158-1167
• Ward, B.K., Mark, P.J., Ingram, D.M., Minchin, R.F., Ratajczak, T., Expression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer (1999) Breast Cancer Res. Treat., 58, pp. 267-280
• Ratajczak, T., Steroid Receptor-Associated Immunophilins: Candidates for Diverse Drug-Targeting Approaches in Disease (2015) Curr. Mol. Pharmacol., 9, pp. 66-95
• Gougelet, A., Bouclier, C., Marsaud, V., Maillard, S., Mueller, S.O., Korach, K.S., Renoir, J.M., Estrogen receptor α and beta subtype expression and transactivation capacity are differentially affected by receptor-, hsp90-and immunophilin-ligands in human breast cancer cells (2005) J. Steroid Biochem. Mol. Biol., 94, pp. 71-81
• Periyasamy, S., Warrier, M., Tillekeratne, M.P., Shou, W., Sanchez, E.R., The immunophilin ligands cyclosporin A and FK506 suppress prostate cancer cell growth by androgen receptor-dependent and-independent mechanisms (2007) Endocrinology, 148, pp. 4716-4726
• Lin, J.F., Xu, J., Tian, H.Y., Gao, X., Chen, Q.X., Gu, Q., Xu, G.J., Zhao, F.K., Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis (2007) Int. J. Cancer, 121, pp. 2596-2605
• Mostaghel, E.A., Page, S.T., Lin, D.W., Fazli, L., Coleman, I.M., True, L.D., Knudsen, B., Matsumoto, A.M., Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: Therapeutic implications for castration-resistant prostate cancer (2007) Cancer Res, 67, pp. 5033-5041
• Periyasamy, S., Hinds, T., Jr., Shemshedini, L., Shou, W., Sanchez, E.R., FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A (2010) Oncogene, 29, pp. 1691-1701
• Ni, L., Yang, C.S., Gioeli, D., Frierson, H., Toft, D.O., Paschal, B.M., FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells (2010) Mol. Cell. Biol., 30, pp. 1243-1253
• Wu, D., Tao, X., Chen, Z.P., Han, J.T., Jia, W.J., Zhu, N., Li, X., He, Y.X., The environmental endocrine disruptor p-nitrophenol interacts with FKBP51, a positive regulator of androgen receptor and inhibits androgen receptor signaling in human cells (2016) J. Hazard. Mater., 307, pp. 193-201
• Joshi, J.B., Patel, D., Morton, D.J., Sharma, P., Zou, J., Hewa Bostanthirige, D., Gorantla, Y., Sivils, J.C., Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52 (2017) Mol. Oncol., 11, pp. 337-357
• Sahu, B., Laakso, M., Pihlajamaa, P., Ovaska, K., Sinielnikov, I., Hautaniemi, S., Janne, O.A., FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells (2013) Cancer Res, 73, pp. 1570-1580
• Kach, J., Conzen, S.D., Szmulewitz, R.Z., Targeting the glucocorticoid receptor in breast and prostate cancers (2015) Sci. Transl. Med., 7
• Yemelyanov, A., Czwornog, J., Chebotaev, D., Karseladze, A., Kulevitch, E., Yang, X., Budunova, I., Tumor suppressor activity of glucocorticoid receptor in the prostate (2007) Oncogene, 26, pp. 1885-1896
• Leach, D.A., Trotta, A.P., Need, E.F., Risbridger, G.P., Taylor, R.A., Buchanan, G., The prognostic value of stromal FK506-binding protein 1 and androgen receptor in prostate cancer outcome (2017) Prostate, 77, pp. 185-195
• Cheung-Flynn, J., Prapapanich, V., Cox, M.B., Riggs, D.L., Suarez-Quian, C., Smith, D.F., Physiological role for the cochaperone FKBP52 in androgen receptor signaling (2005) Mol. Endocrinol., 19, pp. 1654-1666
• Yong, W., Yang, Z., Periyasamy, S., Chen, H., Yucel, S., Li, W., Lin, L.Y., Baskin, L.S., Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology (2007) J. Biol. Chem., 282, pp. 5026-5036
• Yeh, S., Tsai, M.Y., Xu, Q., Mu, X.M., Lardy, H., Huang, K.E., Lin, H., Zhou, X., Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues (2002) Proc. Natl. Acad. Sci. USA, 99, pp. 13498-13503
• Sanchez, E.R., Chaperoning steroidal physiology: Lessons from mouse genetic models of Hsp90 and its cochaperones (2012) Biochim. Biophys. Acta, 1823, pp. 722-729
• Riggs, D.L., Cox, M.B., Tardif, H.L., Hessling, M., Buchner, J., Smith, D.F., Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling (2007) Mol. Cell. Biol., 27, pp. 8658-8669
• Solassol, J., Mange, A., Maudelonde, T., FKBP family proteins as promising new biomarkers for cancer (2011) Curr. Opin. Pharmacol., 11, pp. 320-325
• Russo, D., Merolla, F., Mascolo, M., Ilardi, G., Romano, S., Varricchio, S., Napolitano, V., Di Lorenzo, P.P., FKBP51 Immunohistochemical Expression: A New Prognostic Biomarker for OSCC? (2017) Int. J. Mol. Sci., 18, p. 443
• Bonner, J.M., Boulianne, G.L., Diverse structures, functions and uses of FK506 binding proteins (2017) Cell Signal, 38, pp. 97-105
• Huang, S.L., Chao, C.C., Silencing of Taxol-Sensitizer Genes in Cancer Cells: Lack of Sensitization Effects (2015) Cancers, 7, pp. 1052-1071
• Rotoli, D., Morales, M., Del Carmen Maeso, M., Del Pino Garcia, M., Morales, A., Avila, J., Martin-Vasallo, P., Expression and localization of the immunophilin FKBP51 in colorectal carcinomas and primary metastases, and alterations following oxaliplatin-based chemotherapy (2016) Oncol. Lett., 12, pp. 1315-1322
• Rotoli, D., Morales, M., Avila, J., Maeso, M.D.C., Garcia, M.D.P., Mobasheri, A., Martin-Vasallo, P., Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy (2017) Int. J. Mol. Sci., 18
• Liu, Y., Li, C., Xing, Z., Yuan, X., Wu, Y., Xu, M., Tu, K., Zhao, M., Proteomic mining in the dysplastic liver of WHV/c-myc mice--insights and indicators for early hepatocarcinogenesis (2010) FEBS J, 277, pp. 4039-4053
• Xu, J., Lin, H., Li, G., Sun, Y., Chen, J., Shi, L., Cai, X., Chang, C., The miR-367-3p Increases Sorafenib Chemotherapy Efficacy to Suppress Hepatocellular Carcinoma Metastasis through Altering the Androgen Receptor Signals (2016) Ebiomedicine, 12, pp. 55-67
• Sun, S.C., The non-canonical NF-κB pathway in immunity and inflammation (2017) Nat. Rev. Immunol., 17, pp. 545-558
• Gilmore, T.D., Introduction to NF-κB: Players, pathways, perspectives (2006) Oncogene, 25, pp. 6680-6684
• Mackenzie, G.G., Keen, C.L., Oteiza, P.I., Microtubules are required for NF-κB nuclear translocation in neuroblastoma IMR-32 cells: Modulation by zinc (2006) J. Neurochem., 99, pp. 402-415
• Ghosh, S., Karin, M., Missing pieces in the NF-κB puzzle (2002) Cell, 109, pp. S81-S96
• Gojoubori, T., Ota, H., Kusunoki, M., Nishio, Y., Nishio, K., Iwasa, S., Kaneko, Y., Asano, M., Electrolytically generated acid functional water inhibits NF-κB activity by attenuating nuclear-cytoplasmic shuttling of p65 and p50 subunits (2016) J. Recept. Signal Transduct. Res., 36, pp. 248-253
• Ryo, A., Suizu, F., Yoshida, Y., Perrem, K., Liou, Y.C., Wulf, G., Rottapel, R., Lu, K.P., Regulation of NF-κB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA (2003) Mol. Cell, 12, pp. 1413-1426
• Wulf, G., Ryo, A., Liou, Y.C., Lu, K.P., The prolyl isomerase Pin1 in breast development and cancer (2003) Breast Cancer Res, 5, pp. 76-82
• Wulf, G.M., Ryo, A., Wulf, G.G., Lee, S.W., Niu, T., Petkova, V., Lu, K.P., Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1 (2001) EMBO J, 20, pp. 3459-3472
• Bao, L., Kimzey, A., Sauter, G., Sowadski, J.M., Lu, K.P., Wang, D.G., Prevalent overexpression of prolyl isomerase Pin1 in human cancers (2004) Am. J. Pathol., 164, pp. 1727-1737
• Yoshimura, A., Mori, H., Ohishi, M., Aki, D., Hanada, T., Negative regulation of cytokine signaling influences inflammation (2003) Curr. Opin. Immunol., 15, pp. 704-708
• Romano, S., Xiao, Y., Nakaya, M., D'angelillo, A., Chang, M., Jin, J., Hausch, F., Romano, M.F., FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma (2015) Nucleic Acids Res, 43, pp. 6983-6993
• Romano, S., D'angelillo, A., Pacelli, R., Staibano, S., de Luna, E., Bisogni, R., Eskelinen, E.L., Arra, C., Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells (2010) Cell Death Differ, 17, pp. 145-157
• Pei, H., Li, L., Fridley, B.L., Jenkins, G.D., Kalari, K.R., Lingle, W., Petersen, G., Wang, L., FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt (2009) Cancer Cell, 16, pp. 259-266
• Luo, K., Li, Y., Yin, Y., Li, L., Wu, C., Chen, Y., Nowsheen, S., Lou, Z., USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling (2017) EMBO J, 36, pp. 1434-1446
• Wang, L., FKBP51 regulation of AKT/protein kinase B phosphorylation (2011) Curr. Opin. Pharmacol., 11, pp. 360-364
• Dogan, F., Biray Avci, C., Correlation between telomerase and mTOR pathway in cancer stem cells (2018) Gene, 641, pp. 235-239
• Fruman, D.A., Chiu, H., Hopkins, B.D., Bagrodia, S., Cantley, L.C., Abraham, R.T., The PI3K Pathway in Human Disease (2017) Cell, 170, pp. 605-635
• Koundouros, N., Poulogiannis, G., Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer (2018) Front. Oncol., 8
• Hausch, F., Kozany, C., Theodoropoulou, M., Fabian, A.K., FKBPs and the Akt/mTOR pathway (2013) Cell Cycle, 12, pp. 2366-2370
• Baretic, D., Williams, R.L., The structural basis for mTOR function (2014) Semin. Cell Dev. Biol., 36, pp. 91-101
• Romano, S., Sorrentino, A., Di Pace, A.L., Nappo, G., Mercogliano, C., Romano, M.F., The emerging role of large immunophilin FK506 binding protein 51 in cancer (2011) Curr. Med. Chem., 18, pp. 5424-5429
• Zaytseva, Y.Y., Valentino, J.D., Gulhati, P., Evers, B.M., MTOR inhibitors in cancer therapy (2012) Cancer Lett, 319, pp. 1-7
• Liu, X., Duan, C., Ji, J., Zhang, T., Yuan, X., Zhang, Y., Ma, W., Jiang, Z., Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells (2017) Oncol. Rep., 38, pp. 271-278
• Cazzaniga, M., Verusio, C., Ciccarese, M., Fumagalli, A., Sartori, D., Ancona, C., Airoldi, M., Arcangeli, V., Everolimus (EVE) and exemestane (EXE) in patients with advanced breast cancer aged >/= 65 years: New lessons for clinical practice from the EVA study (2018) Oncotarget, 9
• Hasskarl, J.E., (2018) Recent Results Cancer Res, 211, pp. 101-123
• Gallo, L.I., Lagadari, M., Piwien-Pilipuk, G., Galigniana, M.D., The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress (2011) J. Biol. Chem., 286, pp. 30152-30160
• Akiyama, T., Shiraishi, T., Qin, J., Konno, H., Akiyama, N., Shinzawa, M., Miyauchi, M., Ohashi, H., Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN (2014) PLOS ONE, 9
• Toneatto, J., Guber, S., Charo, N.L., Susperreguy, S., Schwartz, J., Galigniana, M.D., Piwien-Pilipuk, G., Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation (2013) J. Cell Sci., 126, pp. 5357-5368
• Fan, A.C., Young, J.C., Function of cytosolic chaperones in Tom70-mediated mitochondrial import (2011) Protein Pept. Lett., 18, pp. 122-131
• Eisenstein, M., Telomeres: All's well that ends well (2011) Nature, 478, pp. S13-S15
• Gomes, N.M., Shay, J.W., Wright, W.E., Telomere biology in Metazoa (2010) FEBS Lett, 584, pp. 3741-3751
• Shore, D., Bianchi, A., Telomere length regulation: Coupling DNA end processing to feedback regulation of telomerase (2009) EMBO J, 28, pp. 2309-2322
• Calado, R.T., Young, N.S., Telomere diseases (2009) New Engl. J. Med., 361, pp. 2353-2365
• Harley, C.B., Telomerase and cancer therapeutics (2008) Nat. Rev. Cancer, 8, pp. 167-179
• Masutomi, K., Kaneko, S., Hayashi, N., Yamashita, T., Shirota, Y., Kobayashi, K., Murakami, S., Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component (2000) J. Biol. Chem., 275, pp. 22568-22573
• Forsythe, H.L., Jarvis, J.L., Turner, J.W., Elmore, L.W., Holt, S.E., Stable association of hsp90 and p23, but Not hsp70, with active human telomerase (2001) J. Biol. Chem., 276, pp. 15571-15574
• Holt, S.E., Aisner, D.L., Baur, J., Tesmer, V.M., Dy, M., Ouellette, M., Trager, J.B., Shay, J.W., Functional requirement of p23 and Hsp90 in telomerase complexes (1999) Genes Dev, 13, pp. 817-826
• Gaali, S., Kirschner, A., Cuboni, S., Hartmann, J., Kozany, C., Balsevich, G., Namendorf, C., Zannas, A.S., Selective inhibitors of the FK506-binding protein 51 by induced fit (2015) Nat. Chem. Biol., 11, pp. 33-37
• Yao, Y.L., Liang, Y.C., Huang, H.H., Yang, W.M., FKBPs in chromatin modification and cancer (2011) Curr. Opin. Pharmacol., 11, pp. 301-307. , doi:S1471-4892(11)00044-0 [pii]
• Stechschulte, L.A., Sanchez, E.R., FKBP51-a selective modulator of glucocorticoid and androgen sensitivity (2011) Curr. Opin. Pharmacol., 11, pp. 332-337
• Leach, D.A., Buchanan, G., Stromal Androgen Receptor in Prostate Cancer Development and Progression (2017) Cancers, 9, p. 10
• Kim, Y.S., Kim, Y.J., Lee, J.M., Kim, E.K., Park, Y.J., Choe, S.K., Ko, H.J., Kang, C.Y., Functional changes in myeloid-derived suppressor cells (MDSCs) during tumor growth: FKBP51 contributes to the regulation of the immunosuppressive function of MDSCs (2012) J. Immunol., 188, pp. 4226-4234
• Li, L., Lou, Z., Wang, L., The role of FKBP5 in cancer aetiology and chemoresistance (2011) Br. J. Cancer, 104, pp. 19-23
• Mukaide, H., Adachi, Y., Taketani, S., Iwasaki, M., Koike-Kiriyama, N., Shigematsu, A., Shi, M., Kamiyama, Y., FKBP51 expressed by both normal epithelial cells and adenocarcinoma of colon suppresses proliferation of colorectal adenocarcinoma (2008) Cancer Investig, 26, pp. 385-390
• Amiri, A., Noei, F., Feroz, T., Lee, J.M., Geldanamycin anisimycins activate Rho and stimulate Rho-and ROCK-dependent actin stress fiber formation (2007) Mol. Cancer Res., 5, pp. 933-942
• Le Boeuf, F., Houle, F., Sussman, M., Huot, J., Phosphorylation of focal adhesion kinase (FAK) on Ser732 is induced by rho-dependent kinase and is essential for proline-rich tyrosine kinase-2-mediated phosphorylation of FAK on Tyr407 in response to vascular endothelial growth factor (2006) Mol. Biol. Cell, 17, pp. 3508-3520
• Takaoka, M., Ito, S., Miki, Y., Nakanishi, A., FKBP51 regulates cell motility and invasion via RhoA signaling (2017) Cancer Sci, 108, pp. 380-389
• Ostrow, K.L., Park, H.L., Hoque, M.O., Kim, M.S., Liu, J., Argani, P., Westra, W., Sidransky, D., Pharmacologic unmasking of epigenetically silenced genes in breast cancer (2009) Clin. Cancer Res., 15, pp. 1184-1191
• Pearson, J.D., Mohammed, Z., Bacani, J.T., Lai, R., Ingham, R.J., The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein (2012) BMC Cancer, 12
• D'arrigo, P., Russo, M., Rea, A., Tufano, M., Guadagno, E., Del Basso De Caro, M.L.; Pacelli, R.; Hausch, F.; Staibano, S.; Ilardi, G.; et al. A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma (2017) Oncotarget, 8, pp. 68291-68304
• Wirsching, H.G., Galanis, E., Weller, M., Glioblastoma (2016) Handb. Clin. Neurol., 134, pp. 381-397
• Wang, L., Gundelach, J.H., Bram, R.J., Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme (2017) Cell Death Dis, 8
• Ma, S., Boerner, J.E., Tiongyip, C., Weidmann, B., Ryder, N.S., Cooreman, M.P., Lin, K., NIM811, a cyclophilin inhibitor, exhibits potent in vitro activity against hepatitis C virus alone or in combination with α interferon (2006) Antimicrob. Agents Chemother., 50, pp. 2976-2982
• Duzgun, Z., Eroglu, Z., Biray Avci, C., Role of mTOR in glioblastoma (2016) Gene, 575, pp. 187-190
• Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Warner, M., Estrogen receptors: How do they signal and what are their targets (2007) Physiol. Rev., 87, pp. 905-931
• Donley, C., McClelland, K., McKeen, H.D., Nelson, L., Yakkundi, A., Jithesh, P.V., Burrows, J., Prise, K.M., Identification of RBCK1 as a novel regulator of FKBPL: Implications for tumor growth and response to tamoxifen (2014) Oncogene, 33, pp. 3441-3450
• Nelson, L., McKeen, H.D., Marshall, A., Mulrane, L., Starczynski, J., Storr, S.J., Lanigan, F., Hegarty, S., FKBPL: A marker of good prognosis in breast cancer (2015) Oncotarget, 6
• Renoir, J.M., Estradiol receptors in breast cancer cells: Associated co-factors as targets for new therapeutic approaches (2012) Steroids, 77, pp. 1249-1261
• Renoir, J.M., Marsaud, V., Lazennec, G., Estrogen receptor signaling as a target for novel breast cancer therapeutics (2013) Biochem. Pharmacol., 85, pp. 449-465
• Desmetz, C., Bascoul-Mollevi, C., Rochaix, P., Lamy, P.J., Kramar, A., Rouanet, P., Maudelonde, T., Solassol, J., Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women (2009) Clin. Cancer Res., 15, pp. 4733-4741
• Dhamad, A.E., Zhou, Z., Zhou, J., Du, Y., Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor α (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction (2016) Plos ONE, 11
• The Human Protein Atlas, , https://www.proteinatlas.org/ENSG00000004478-FKBP4/pathology, (accessed on 20 October 2018)
• Garifulin, O.M., Kykot, V.O., Gridina, N.Y., Kiyamova, R.G., Gout, I.T., Filonenko, V.V., Application of serex-analysis for identification of human colon cancer antigens (2015) Exp. Oncol., 37, pp. 173-180
• Duthie, K.A., Osborne, L.C., Foster, L.J., Abraham, N., Proteomics analysis of interleukin (IL)-7-induced signaling effectors shows selective changes in IL-7Rα449F knock-in T cell progenitors (2007) Mol. Cell. Proteom., 6, pp. 1700-1710
• Quinta, H.R., Galigniana, N.M., Erlejman, A.G., Lagadari, M., Piwien-Pilipuk, G., Galigniana, M.D., Management of cytoskeleton architecture by molecular chaperones and immunophilins (2011) Cell Signal, 23, pp. 1907-1920
• Quinta, H.R., Galigniana, M.D., The neuroregenerative mechanism mediated by the Hsp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation (2012) Br. J. Pharmacol., 166, pp. 637-649
• Ott, M., Litzenburger, U.M., Rauschenbach, K.J., Bunse, L., Ochs, K., Sahm, F., Pusch, S., von Deimling, A., Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway (2015) Glia, 63, pp. 78-90
• Jiang, W., Cazacu, S., Xiang, C., Zenklusen, J.C., Fine, H.A., Berens, M., Armstrong, B., Mikkelsen, T., FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-κB signaling pathway (2008) Neoplasia, 10, pp. 235-243
• Lim, S.O., Park, S.J., Kim, W., Park, S.G., Kim, H.J., Kim, Y.I., Sohn, T.S., Jung, G., Proteome analysis of hepatocellular carcinoma (2002) Biochem. Biophys. Res. Commun., 291, pp. 1031-1037
• Ruiz-Estevez, M., Staats, J., Paatela, E., Munson, D., Katoku-Kikyo, N., Yuan, C., Asakura, Y., Asakura, A., Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization (2018) Cell Rep, 25, pp. 2537-2551
• Schulke, J.P., Wochnik, G.M., Lang-Rollin, I., Gassen, N.C., Knapp, R.T., Berning, B., Yassouridis, A., Rein, T., Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors (2010) Plos ONE, 5
• Tranguch, S., Smith, D.F., Dey, S.K., Progesterone receptor requires a co-chaperone for signalling in uterine biology and implantation (2006) Reprod. Biomed. Online, 13, pp. 651-660
• Hubler, T.R., Denny, W.B., Valentine, D.L., Cheung-Flynn, J., Smith, D.F., Scammell, J.G., The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness (2003) Endocrinology, 144, pp. 2380-2387
• Febbo, P.G., Lowenberg, M., Thorner, A.R., Brown, M., Loda, M., Golub, T.R., Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer (2005) J. Urol., 173, pp. 1772-1777
• Lagadari, M., Leo, S.A., Camisay, M.F., Galigniana, M.D., Erlejman, A.G., Regulation of NF-κB signalling cascade by immunophilins (2016) Curr. Mol. Pharmacol., 9, pp. 99-108
• Quintá, H.R., Maschi, D., Gomez-Sanchez, C., Piwien-Pilipuk, G., Galigniana, M.D., Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth (2010) J. Neurochem., 115, pp. 716-734
• Jinwal, U.K., Koren, J., 3Rd, Borysov, S.I., Schmid, A.B., Abisambra, J.F., Blair, L.J., Johnson, A.G., O'leary, J.C., 3Rd, The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules (2010) J. Neurosci., 30, pp. 591-599
• Chambraud, B., Sardin, E., Giustiniani, J., Dounane, O., Schumacher, M., Goedert, M., Baulieu, E.E., A role for FKBP52 in Tau protein function (2010) Proc. Natl. Acad. Sci. USA, 107, pp. 2658-2663
• Sanokawa-Akakura, R., Dai, H., Akakura, S., Weinstein, D., Fajardo, J.E., Lang, S.E., Wadsworth, S., Birge, R.B., A novel role for the immunophilin FKBP52 in copper transport (2004) J. Biol. Chem., 279, pp. 27845-27848
• Zheng, W., Monnot, A.D., Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases (2012) Pharmacol. Ther., 133, pp. 177-188
• Mills, E., Dong, X.P., Wang, F., Xu, H., Mechanisms of brain iron transport: Insight into neurodegeneration and CNS disorders (2010) Future Med. Chem., 2, pp. 51-64
• Warrier, M., Hinds, T.D., Jr., Ledford, K.J., Cash, H.A., Patel, P.R., Bowman, T.A., Stechschulte, L.A., Najjar, S.M., Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice (2010) Endocrinology, 151, pp. 3225-3236
• Rosen, E.D., Macdougald, O.A., Adipocyte differentiation from the inside out (2006) Nat. Rev. Mol. Cell Biol., 7, pp. 885-896
• Nguyen, M.T., Csermely, P., Soti, C., Hsp90 chaperones PPARgamma and regulates differentiation and survival of 3T3-L1 adipocytes (2013) Cell Death Differ, 20, pp. 1654-1663
• Desarzens, S., Liao, W.H., Mammi, C., Caprio, M., Faresse, N., Hsp90 blockers inhibit adipocyte differentiation and fat mass accumulation (2014) Plos ONE, 9
• Verstraeten, V.L., Renes, J., Ramaekers, F.C., Kamps, M., Kuijpers, H.J., Verheyen, F., Wabitsch, M., Broers, J.L., Reorganization of the nuclear lamina and cytoskeleton in adipogenesis (2011) Histochem. Cell Biol., 135, pp. 251-261
• D'angelo, M.A., Hetzer, M.W., The role of the nuclear envelope in cellular organization (2006) Cell. Mol. Life Sci., 63, pp. 316-332
• Stuurman, N., Identification of a conserved phosphorylation site modulating nuclear lamin polymerization (1997) FEBS Lett, 401, pp. 171-174
• Stechschulte, L.A., Hinds, T.D., Jr., Ghanem, S.S., Shou, W., Najjar, S.M., Sanchez, E.R., FKBP51 reciprocally regulates GRα and PPARgamma activation via the Akt-p38 pathway (2014) Mol. Endocrinol., 28, pp. 1254-1264
• Stechschulte, L.A., Hinds, T.D., Jr., Khuder, S.S., Shou, W., Najjar, S.M., Sanchez, E.R., FKBP51 controls cellular adipogenesis through p38 kinase-mediated phosphorylation of GRα and PPARgamma (2014) Mol. Endocrinol., 28, pp. 1265-1275
• Tontonoz, P., Spiegelman, B.M., Fat and beyond: The diverse biology of PPARgamma (2008) Annu. Rev. Biochem., 77, pp. 289-312
• O'leary, J.C., 3Rd, Dharia, S., Blair, L.J., Brady, S., Johnson, A.G., Peters, M., Cheung-Flynn, J., Weeber, E.J., A new anti-depressive strategy for the elderly: Ablation of FKBP5/FKBP51 (2011) Plos ONE, 6
• Touma, C., Gassen, N.C., Herrmann, L., Cheung-Flynn, J., Bull, D.R., Ionescu, I.A., Heinzmann, J.M., Depping, A.M., FK506 binding protein 5 shapes stress responsiveness: Modulation of neuroendocrine reactivity and coping behavior (2011) Biol. Psychiatry, 70, pp. 928-936
• Hartmann, J., Wagner, K.V., Liebl, C., Scharf, S.H., Wang, X.D., Wolf, M., Hausch, F., Touma, C., The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress (2012) Neuropharmacology, 62, pp. 332-339
• Stechschulte, L.A., Qiu, B., Warrier, M., Hinds, T.D., Jr., Zhang, M., Gu, H., Xu, Y., Najjar, S.M., FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARgamma Agonist Rosiglitazone (2016) Endocrinology, 157, pp. 3888-3900
• Stepanova, L., Leng, X., Parker, S.B., Harper, J.W., Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4 (1996) Genes Dev, 10, pp. 1491-1502
• Verba, K.A., Wang, R.Y., Arakawa, A., Liu, Y., Shirouzu, M., Yokoyama, S., Agard, D.A., Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase (2016) Science, 352, pp. 1542-1547
• Hardwick, L.J.A., Azzarelli, R., Philpott, A., Cell cycle-dependent phosphorylation and regulation of cellular differentiation (2018) Biochem. Soc. Trans., 46, pp. 1083-1091
• Scharf, S.H., Liebl, C., Binder, E.B., Schmidt, M.V., Muller, M.B., Expression and regulation of the Fkbp5 gene in the adult mouse brain (2011) Plos ONE, 6
• Zannas, A.S., Wiechmann, T., Gassen, N.C., Binder, E.B., Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications (2016) Neuropsychopharmacology, 41, pp. 261-274
• Fries, G.R., Gassen, N.C., Schmidt, U., Rein, T., The FKBP51-Glucocorticoid Receptor Balance in Stress-Related Mental Disorders (2015) Curr. Mol. Pharmacol., 9, pp. 126-140
• Paquette, A.G., Lester, B.M., Koestler, D.C., Lesseur, C., Armstrong, D.A., Marsit, C.J., Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort (2014) Plos ONE, 9
• Criado-Marrero, M., Rein, T., Binder, E.B., Porter, J.T., Koren, J., 3Rd, Blair, L.J., Hsp90 and FKBP51: Complex regulators of psychiatric diseases (2018) Philos. Trans. R. Soc. Lond. Ser. Biol. Sci., 373
• Hartmann, J., Wagner, K.V., Gaali, S., Kirschner, A., Kozany, C., Ruhter, G., Dedic, N., Westerholz, S., Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties (2015) J. Neurosci., 35, pp. 9007-9016
• Ising, M., Depping, A.M., Siebertz, A., Lucae, S., Unschuld, P.G., Kloiber, S., Horstmann, S., Holsboer, F., Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls (2008) Eur. J. Neurosci., 28, pp. 389-398
• Mahon, P.B., Zandi, P.P., Potash, J.B., Nestadt, G., Wand, G.S., Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults (2013) Psychopharmacology, 227, pp. 231-241
• Shibuya, N., Suzuki, A., Sadahiro, R., Kamata, M., Matsumoto, Y., Goto, K., Hozumi, Y., Otani, K., Association study between a functional polymorphism of FK506-binding protein 51 (FKBP5) gene and personality traits in healthy subjects (2010) Neurosci. Lett., 485, pp. 194-197
• Fani, N., King, T.Z., Reiser, E., Binder, E.B., Jovanovic, T., Bradley, B., Ressler, K.J., FKBP5 genotype and structural integrity of the posterior cingulum (2014) Neuropsychopharmacology, 39, pp. 1206-1213
• Fani, N., Gutman, D., Tone, E.B., Almli, L., Mercer, K.B., Davis, J., Glover, E., Dinov, I.D., FKBP5 and attention bias for threat: Associations with hippocampal function and shape (2013) JAMA Psychiatry, 70, pp. 392-400
• Fujii, T., Ota, M., Hori, H., Hattori, K., Teraishi, T., Sasayama, D., Higuchi, T., Kunugi, H., Association between the common functional FKBP5 variant (Rs1360780) and brain structure in a non-clinical population (2014) J. Psychiatr. Res., 58, pp. 96-101
• Levy-Gigi, E., Szabo, C., Kelemen, O., Keri, S., Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy (2013) Biol. Psychiatry, 74, pp. 793-800
• White, M.G., Bogdan, R., Fisher, P.M., Munoz, K.E., Williamson, D.E., Hariri, A.R., FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity (2012) Genesbrainand Behav, 11, pp. 869-878
• Klengel, T., Binder, E.B., Allele-specific epigenetic modification: A molecular mechanism for gene-environment interactions in stress-related psychiatric disorders? (2013) Epigenomics, 5, pp. 109-112
• Pohlmann, M.L., Hausl, A.S., Harbich, D., Balsevich, G., Engelhardt, C., Feng, X., Breitsamer, M., Schmidt, M.V., Pharmacological Modulation of the Psychiatric Risk Factor FKBP51 Alters Efficiency of Common Antidepressant Drugs (2018) Front. Behav. Neurosci., 12
• Gassen, N.C., Fries, G.R., Zannas, A.S., Hartmann, J., Zschocke, J., Hafner, K., Carrillo-Roa, T., Hoeijmakers, L., Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine (2015) Sci. Signal., 8
• Gassen, N.C., Hartmann, J., Zannas, A.S., Kretzschmar, A., Zschocke, J., Maccarrone, G., Hafner, K., Wagner, K.V., FKBP51 inhibits GSK3beta and augments the effects of distinct psychotropic medications (2016) Mol. Psychiatry, 21, pp. 277-289

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