Artículo

Di Yorio, M.P.; Pérez Sirkin, D.I.; Muñoz-Cueto, J.A.; Delgadin, T.H.; Tsutsui, K.; Somoza, G.M.; Vissio, P.G. "Morphological relationship between GnIH and GnRH neurons in the brain of the neotropical cichlid fish Cichlasoma dimerus" (2019) General and Comparative Endocrinology. 273:144-151
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Abstract:

Reproduction is regulated by the hypothalamic-pituitary-gonadal axis. The first neuropeptide identified that regulates this function was the decapeptide gonadotropin-releasing hormone (GnRH). Nowadays, in gnatostomates, a number of GnRH variants have been identified and classified into three different types: GnRH1, GnRH2, and GnRH3. Almost 30 years later, a new peptide that inhibits gonadotropin synthesis and secretion was discovered and thus named as gonadotropin-inhibitory hormone (GnIH). In avians and mammals, the interaction and regulation between GnRH and GnIH neurons has been widely studied; however, in other vertebrate groups there is little information about the relationship between these neurons. In previous works, three GnRH variants and a GnIH propeptide were characterized in Cichlasoma dimerus, and it was demonstrated that GnIH inhibited gonadotropins release in this species. Because no innervation was detected at the pituitary level, we speculate that GnIH would inhibit gonadotropins via GnRH. Thus, the aim of the present study was to evaluate the anatomical relationship between neurons expressing GnIH and the three GnRH variants by double labelling confocal immunofluorescence in adults of C. dimerus. Our results showed no apparent contacts between GnIH and GnRH1, fiber to fiber interactions between GnIH and GnRH2, and co-localization of GnIH and GnRH3 variant in neurons of the nucleus olfacto-retinalis. In conclusion, whether GnIH regulates the expression or secretion of GnRH1 in this species, an indirect modulation seems more plausible. Moreover, the present results suggest an interaction between GnIH and GnRH2 systems. Finally, new clues were provided to investigate the role of nucleus olfacto-retinalis cells and putative GnIH and GnRH3 interactions in the modulation of the reproductive network in teleost fish. © 2018 Elsevier Inc.

Registro:

Documento: Artículo
Título:Morphological relationship between GnIH and GnRH neurons in the brain of the neotropical cichlid fish Cichlasoma dimerus
Autor:Di Yorio, M.P.; Pérez Sirkin, D.I.; Muñoz-Cueto, J.A.; Delgadin, T.H.; Tsutsui, K.; Somoza, G.M.; Vissio, P.G.
Filiación:Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Intituto de Biodiversidad y Biología Experimental y Aplicada (IBBEA), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Biology, Faculty of Marine and Environmental Sciences, University of Cádiz, Marine Campus of International Excellence (CEIMAR) and Agrifood Campus of International Excellence (ceiA3), INMAR-CACYTMAR Research Institutes, Puerto Real University Campus, Puerto Real, Spain
Department of Biology and Center for Medical Life Science, Waseda UniversityTokyo 162-8480, Japan
Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico de Chascomús, CONICET-UNSAM, Chascomús, Argentina
Palabras clave:Brain; Fish; GnIH; GnRH variants; Neurons; Pituitary
Año:2019
Volumen:273
Página de inicio:144
Página de fin:151
DOI: http://dx.doi.org/10.1016/j.ygcen.2018.06.010
Título revista:General and Comparative Endocrinology
Título revista abreviado:Gen. Comp. Endocrinol.
ISSN:00166480
CODEN:GCENA
Registro:http://digital.bl.fcen.uba.ar/collection/paper/document/paper_00166480_v273_n_p144_DiYorio

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Citas:

---------- APA ----------
Di Yorio, M.P., Pérez Sirkin, D.I., Muñoz-Cueto, J.A., Delgadin, T.H., Tsutsui, K., Somoza, G.M. & Vissio, P.G. (2019) . Morphological relationship between GnIH and GnRH neurons in the brain of the neotropical cichlid fish Cichlasoma dimerus. General and Comparative Endocrinology, 273, 144-151.
http://dx.doi.org/10.1016/j.ygcen.2018.06.010
---------- CHICAGO ----------
Di Yorio, M.P., Pérez Sirkin, D.I., Muñoz-Cueto, J.A., Delgadin, T.H., Tsutsui, K., Somoza, G.M., et al. "Morphological relationship between GnIH and GnRH neurons in the brain of the neotropical cichlid fish Cichlasoma dimerus" . General and Comparative Endocrinology 273 (2019) : 144-151.
http://dx.doi.org/10.1016/j.ygcen.2018.06.010
---------- MLA ----------
Di Yorio, M.P., Pérez Sirkin, D.I., Muñoz-Cueto, J.A., Delgadin, T.H., Tsutsui, K., Somoza, G.M., et al. "Morphological relationship between GnIH and GnRH neurons in the brain of the neotropical cichlid fish Cichlasoma dimerus" . General and Comparative Endocrinology, vol. 273, 2019, pp. 144-151.
http://dx.doi.org/10.1016/j.ygcen.2018.06.010
---------- VANCOUVER ----------
Di Yorio, M.P., Pérez Sirkin, D.I., Muñoz-Cueto, J.A., Delgadin, T.H., Tsutsui, K., Somoza, G.M., et al. Morphological relationship between GnIH and GnRH neurons in the brain of the neotropical cichlid fish Cichlasoma dimerus. Gen. Comp. Endocrinol. 2019;273:144-151.
http://dx.doi.org/10.1016/j.ygcen.2018.06.010