Artículo

Shmidt, M.S.; Arroyo Mañez, P.; Stortz, C.A.; Perillo, I.A.; Vega, D.; Blanco, M.M. "Alkylation of 2- and 3-alkoxycarbonyl-4-quinolinones. DFT study on the regioselectivity" (2017) Journal of Molecular Structure. 1128:142-150
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Abstract:

The reaction of 2-alkoxycarbonyl-4-quinolinones (1) with a variety of alkylating reagents under different conditions, lead to the corresponding O-alkylated products. The behavior in basic medium of compounds 1 differs from the 3-alkoxycarbonyl-4-quinolinones (4) isomers suggesting that the position of the carboxylate group determines the regioselectivity of the reaction. DFT calculations allow us to conclude that for 3-alkoxycarbonyl-4-quinolinones, the N-alkylation would be thermodynamically and kinetically favored. But for 2-alkoxycarbonyl-4-quinolinones the side chain in the 2-position of the ring prevents the planar approximation to the contiguous heteroatom leading to a more favorable O-alkylation transition state. Crystal structure of an O-alkylated product is determined by single crystal X-ray diffractometry. © 2016 Elsevier B.V.

Registro:

Documento: Artículo
Título:Alkylation of 2- and 3-alkoxycarbonyl-4-quinolinones. DFT study on the regioselectivity
Autor:Shmidt, M.S.; Arroyo Mañez, P.; Stortz, C.A.; Perillo, I.A.; Vega, D.; Blanco, M.M.
Filiación:Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Química Orgánica, Junín 956, CABA, 1113, Argentina
Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Ciudad Universitaria, CABA, 1428, Argentina
Comisión Nacional de Energía Atómica, CAC-GAI y ANN, Departamento Física de la Materia Condensada y Universidad Nacional de San Martín, ECyT, Av. Gral. Paz 1499, San Martín, Buenos Aires 1650, Argentina
Palabras clave:4-Quinolones; Alkylation; B3LYP; DFT; Regioselectivity; Alkylation; Carboxylation; Chemical reactions; Isomers; Regioselectivity; Single crystals; X ray diffraction analysis; 4-Quinolones; Alkylating reagents; B3LYP; Basic medium; Carboxylate groups; DFT calculation; N-alkylation; Transition state; Crystal structure
Año:2017
Volumen:1128
Página de inicio:142
Página de fin:150
DOI: http://dx.doi.org/10.1016/j.molstruc.2016.08.057
Título revista:Journal of Molecular Structure
Título revista abreviado:J. Mol. Struct.
ISSN:00222860
CODEN:JMOSB
Registro:http://digital.bl.fcen.uba.ar/collection/paper/document/paper_00222860_v1128_n_p142_Shmidt

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Citas:

---------- APA ----------
Shmidt, M.S., Arroyo Mañez, P., Stortz, C.A., Perillo, I.A., Vega, D. & Blanco, M.M. (2017) . Alkylation of 2- and 3-alkoxycarbonyl-4-quinolinones. DFT study on the regioselectivity. Journal of Molecular Structure, 1128, 142-150.
http://dx.doi.org/10.1016/j.molstruc.2016.08.057
---------- CHICAGO ----------
Shmidt, M.S., Arroyo Mañez, P., Stortz, C.A., Perillo, I.A., Vega, D., Blanco, M.M. "Alkylation of 2- and 3-alkoxycarbonyl-4-quinolinones. DFT study on the regioselectivity" . Journal of Molecular Structure 1128 (2017) : 142-150.
http://dx.doi.org/10.1016/j.molstruc.2016.08.057
---------- MLA ----------
Shmidt, M.S., Arroyo Mañez, P., Stortz, C.A., Perillo, I.A., Vega, D., Blanco, M.M. "Alkylation of 2- and 3-alkoxycarbonyl-4-quinolinones. DFT study on the regioselectivity" . Journal of Molecular Structure, vol. 1128, 2017, pp. 142-150.
http://dx.doi.org/10.1016/j.molstruc.2016.08.057
---------- VANCOUVER ----------
Shmidt, M.S., Arroyo Mañez, P., Stortz, C.A., Perillo, I.A., Vega, D., Blanco, M.M. Alkylation of 2- and 3-alkoxycarbonyl-4-quinolinones. DFT study on the regioselectivity. J. Mol. Struct. 2017;1128:142-150.
http://dx.doi.org/10.1016/j.molstruc.2016.08.057