Artículo

Abulafia, C.; Fiorentini, L.; Loewenstein, D.A.; Curiel-Cid, R.; Sevlever, G.; Nemeroff, C.B.; Villarreal, M.F.; Vigo, D.E.; Guinjoan, S.M. "Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients" (2019) Journal of Psychiatric Research. 112:23-29
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Episodic memory deficits are traditionally seen as the hallmark cognitive impairment during the prodromal continuum of late-onset Alzheimer's disease (LOAD). Previous studies identified early brain alterations in regions subserving executive functions in asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD), suggesting that premature episodic memory deficits could be associated to executive dysfunction in this model. We hypothesized that O-LOAD would exhibit reduced executive performance evidenced by increased errors and decreased strategy use on an episodic memory task. We assessed 32 asymptomatic middle-aged O-LOAD and 28 age-equivalent control subjects (CS) with several tests that measure executive functions and the Rey Auditory Verbal Learning Test (RAVLT) to measure memory performance. All tests were scored using both traditional and process scores (quantification of errors and strategies underlying overall performance). T-tests were used to compare performance between both groups and Spearman correlations were implemented to measure associations between variables. O-LOAD participants exhibited decreased executive performance compared to CS as it relates to initiation time (Tower of London), mental switching (Trail Making Test B), and interference effects (Stroop Word-Color condition). Traditional RAVLT measures showed a poorer performance by O-LOAD and RAVLT process scores revealed increased interference effects on this group. Positive correlations (r s ) were found between the executive measures and several RAVLT measures for O-LOAD but not for CS. In conclusion, O-LOAD participants exhibited early subtle cognitive changes in executive processing. Observed memory difficulties may be associated in part to executive deficits suggesting an interplay between memory and executive functions. Process score impairments were observed earlier than clinical decline on neuropsychological scores in this at-risk cohort and might be useful cognitive markers of preclinical LOAD. © 2019 Elsevier Ltd

Registro:

Documento: Artículo
Título:Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients
Autor:Abulafia, C.; Fiorentini, L.; Loewenstein, D.A.; Curiel-Cid, R.; Sevlever, G.; Nemeroff, C.B.; Villarreal, M.F.; Vigo, D.E.; Guinjoan, S.M.
Filiación:Grupo de Investigación en Neurociencias Aplicadas a las Alteraciones de la Conducta. FLENI, Buenos Aires, Argentina
National Council for Scientific and Technological Research (CONICET), Argentina
Institute for Biomedical Research (BIOMED), School of Medical Sciences, Universidad Católica Argentina, Buenos Aires, Argentina
Servicio de Psiquiatría. FLENI, Buenos Aires, Argentina
Department of Psychiatry and Behavioral Sciences and Center on Aging, Miller School of Medicine, University of Miami, United States
Departamento de Neuropatología y Biología Molecular. FLENI, Buenos Aires, Argentina
Departamento de Docencia e Investigación. FLENI, Buenos Aires, Argentina
Institute of Early Life Adversity Research, Dell Medical School, The University of Texas, Austin, United States
Department of Physics (FCEyN), University of Buenos Aires, Argentina
School of Psychology and Educational Sciences, Katholieke Universiteit Leuven, Belgium
Departamento de Psiquiatría y Salud Mental, Unidad docente FLENI, Universidad de Buenos Aires, Facultad de Medicina, Argentina
Palabras clave:Executive functions; Preclinical late-onset Alzheimer's disease; Process scores; RAVLT; Subtle cognitive changes; adult; Alzheimer disease; Article; Beck Depression Inventory; controlled study; cross-sectional study; depression; educational status; episodic memory; executive function; family history; female; human; intelligence; major clinical study; male; middle aged; Mini Mental State Examination; neuropsychological test; priority journal; progeny; Rey auditory verbal learning test; Stroop test; tower of London test; trail making test
Año:2019
Volumen:112
Página de inicio:23
Página de fin:29
DOI: http://dx.doi.org/10.1016/j.jpsychires.2019.02.016
Título revista:Journal of Psychiatric Research
Título revista abreviado:J. Psychiatr. Res.
ISSN:00223956
CODEN:JPYRA
Registro:http://digital.bl.fcen.uba.ar/collection/paper/document/paper_00223956_v112_n_p23_Abulafia

Referencias:

  • Abulafia, C., Duarte-Abritta, B., Villarreal, M.F., Relationship between cognitive and sleep-wake variables in asymptomatic offspring of patients with late-onset alzheimer's disease (2017) Front. Aging Neurosci., 9. , 93: 1–8
  • Abulafia, C., Loewenstein, D., Curiel-Cid, R., Brain structural and amyloid correlates of recovery from semantic interference in cognitively normal individuals with or without family history of late-onset alzheimer's disease (2019) J. Neuropsychiatry Clin. Neurosci., 31 (1), pp. 25-36
  • Albert, M.S., Cognitive and neurobiologic markers of early Alzheimer disease (1996) P Natl Acad Sci USA, 93 (24), pp. 13547-13551
  • Ballard, C., O'Sullivan, M.J., Alzheimer disease and stroke: cognitive and neuroimaging predictors of AD and stroke (2013) Nat. Rev. Neurol., 9, pp. 605-606
  • Baudic, S., Dalla Barba, G., Thibaudet, M.C., Executive function deficits in early Alzheimer's disease and their relations with episodic memory (2006) Arch. Clin. Neuropsychol., 21 (1), pp. 15-21
  • Beck, A.T., Steer, R.A., Brown, G.K., Beck Depression Inventory-II (1996), Psychological Corporation San Antonio, TX; Binetti, G., Magni, E., Padovani, A., Executive dysfunction in early Alzheimer's disease (1996) J. Neurol. Neurosurg. Psychiatr., 60 (1), pp. 91-93
  • Blacker, D., Lee, H., Muzikansky, A., Neuropsychological measures in normal individuals that predict subsequent cognitive decline (2007) Arch. Neurol., 64 (6), pp. 862-871
  • Blanco Martín, E., Ugarriza Serrano, I., Elcoroaristizabal Martín, X., Dysexecutive syndrome in amnesic mild cognitive impairment: a multicenter study (2016) BMC Neurol., 16, pp. 1-8
  • Brandt, J., Ph, D., Aretouli, E., Selectivity of executive function deficits in mild cognitive impairment (2009) Neuropsychology, 23, pp. 607-618
  • Christidi, F., Kararizou, E., Triantafyllou, N., Derived Trail Making Test indices: demographics and cognitive background variables across the adult life span (2015) Aging Neuropsychol. Cognit., 22 (6), pp. 667-678
  • Culbertson, W.C., Zillmer, E., Tower of London-Drexel University (TOLDX). Multi-Health Systems (2001), North Tonawanda NY; Curiel, R., Crocco, E., Czaja, S., Deficits in semantic cuing, proactive and retroactive interference as early features of Alzheimer's disease (2013) Alzheimers Dement, 9 (4), p. P456
  • Curiel, R.E., Loewenstein, D.A., Rosselli, M., Semantic intrusions and failure to recover from semantic interference in mild cognitive impairment: relationship to amyloid and cortical thickness (2018) Curr. Alzheimer Res., 15 (9), pp. 848-855
  • Dickerson, B.C., Atri, A., Dementia: Comprehensive Principles and Practice (2014), Oxford University Press UK; Donix, M., Ercoli, L.M., Siddarth, P., Influence of alzheimer disease family history and genetic risk on cognitive performance in healthy middle-aged and older people (2012) Am. J. Geriatr. Psychiatry, 20, pp. 565-573
  • Duarte-Abritta, B., Villarreal, M.F., Abulafia, C., Cortical thickness, brain metabolic activity, and in vivo amyloid deposition in asymptomatic, middle-aged offspring of patients with late-onset Alzheimer's disease (2018) J. Psychiatr. Res., 107, pp. 11-18
  • Edmonds, E.C., Delano-Wood, L., Galasko, D.R., Subtle cognitive decline and biomarker staging in preclinical alzheimer's disease (2015) J Alzheimers Dis, 47, pp. 231-242
  • Folstein, M.F., Folstein, S.E., McHugh, P.R., Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician (1975) J. Psychiatr. Res., 12 (3), pp. 189-198
  • Golden, C.J., Stroop Color and Word Test: a Manual for Clinical and Experimental Uses (1978), Stoelting Chicago, IL; Hazlett, K.E., Figueroa, C.M., Nielson, K.A., Executive functioning and risk for alzheimer's disease in the cognitively intact: family history predicts Wisconsin card sorting test performance (2015) Neuropsychology, 29, pp. 582-591
  • Houston, W.S., Delis, D.C., Lansing, A., Executive function asymmetry in older adults genetically at-risk for Alzheimer's disease: verbal versus design fluency (2005) J. Int. Neuropsychol. Soc., 11, pp. 629-642. , 2005
  • Jaeger, R.G., Halliday, T.M., On confirmatory versus exploratory research (1998) Herpetologica, 54, pp. S64-S66
  • Johns, E.K., Phillips, N.A., Belleville, S., The profile of executive functioning in amnestic mild cognitive impairment: disproportionate deficits in inhibitory control (2012) J. Int. Neuropsychol. Soc., 18 (3), pp. 541-555
  • Jurado, M.B., Rosselli, M., The elusive nature of executive functions: a review of our current understanding (2007) Neuropsychol. Rev., 17, pp. 213-233
  • Kaplan, E., The process approach to neuropsychological assessment (1988) Aphasiology, 2 (3-4), pp. 309-311
  • Kirova, A.M., Bays, R.B., Lagalwar, S., Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer's disease (2015) BioMed Res. Int., 748212
  • Lezak, M.D., Howieson, D.B., Loring, D.W., Neuropsychological Assessment (2004), Oxford University Press USA; Libon, D.J., Bondi, M.W., Price, C.C., Verbal serial list learning in mild cognitive impairment: a profile analysis of interference, forgetting, and errors (2011) J. Int. Neuropsychol. Soc., 17, pp. 905-914
  • Loewenstein, D.A., Curiel, R.E., DeKosky, S., Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment (2018) Neurology, 91 (10), pp. 976-984
  • Loewenstein, D.A., Curiel, R.E., Duara, R., Novel cognitive paradigms for the detection of memory impairment in preclinical Alzheimer's disease (2018) Assessment, 25, pp. 348-359
  • Loewenstein, D.A., Curiel, R.E., Wright, C., Recovery from proactive semantic interference in mild cognitive impairment and normal aging: relationship to atrophy in brain regions vulnerable to alzheimer's disease (2017) J Alzheimers Dis, 56, pp. 1119-1126
  • McDonald, J., Handbook of Biological Statistics (2014), third ed. Sparky House Publishing. Baltimore, MD; Moro, V., Condoleo, M.T., Valbusa, V., Cognitive stimulation of executive functions in mild cognitive impairment: specific efficacy and impact in memory (2015) Am. J. Alzheimers Dis., 30 (2), pp. 153-164
  • Rapp, M.A., Reischies, F.M., Attention and executive control predict Alzheimer disease in late life: results from the Berlin Aging Study (BASE) (2005) Am. J. Geriatr. Psychiatry, 13 (2), pp. 134-141
  • Reiner, A., Yekutieli, D., Benjamini, Y., Identifying differentially expressed genes using false discovery rate controlling procedures (2003) Bioinformatics, 19 (3), pp. 368-375
  • Reinvang, I., Grambaite, R., Espeseth, T., Executive dysfunction in MCI: subtype or early symptom (2012) Int. J. Alzheimer's Dis., , 2012
  • Reinvang, I., Winjevoll, I.L., Rootwelt, H., Working memory deficits in healthy APOE epsilon 4 carriers (2010) Neuropsychologia, 48 (2), pp. 566-573
  • Reitan, R.M., Wolfson, D., The Halstead-Reitan Neuropsychological Test Battery: theory and Clinical Interpretation (1985), Neuropsychology Press Tucson, AZ; Rey, A., L'examen clinique en psychologie (1964), Presses Universitaires de France Paris; Rosen, W.G., Terry, R.D., Fuld, P.A., Pathological verification of ischemic score in differentiation of dementias (1980) Ann. Neurol., 7 (5), pp. 486-488
  • Salmon, D., Bondi, M., Neuropsychological assessment of dementia (2009) Annu. Rev. Psychol., 60, pp. 257-282
  • Sánchez, S.M., Abulafia, C., Duarte-Abritta, B., Failure to recover from proactive semantic interference and abnormal limbic connectivity in asymptomatic, middle-aged offspring of patients with late-onset alzheimer's disease (2017) J Alzheimers Dis, 60, pp. 1183-1193
  • Schmidt, M., Rey Auditory Verbal Learning Test: A Handbook (1996), Western Psychological Services Los Angeles, CA; Sierra Sanjurjo, N., Montañes, P., Sierra Matamoros, F.A., Estimating intelligence in Spanish: regression equations with the Word Accentuation Test and demographic variables in Latin America (2015) Appl Neuropsych-Adul., 22 (4), pp. 252-261
  • Spreen, O., Benton, A.L., Neurosensory Center Comprehensive Examination for Aphasia (1977), Neuropsychological Laboratory Victoria, BC; Strauss, E., Sherman, E.M., Spreen, O., A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary (2006), third ed. Oxford University Press New York, NY; Swanberg, M.M., Tractenberg, R.E., Mohs, R., Executive dysfunction in Alzheimer disease (2004) Arch Neurol-Chicago., 61 (4), pp. 556-560
  • Thomas, K.R., Eppig, J., Edmonds, E.C., Word-list intrusion errors predict progression to mild cognitive impairment (2018) Neuropsychology, 32, pp. 235-245
  • Troyer, A.K., Moscovitch, M., Winocur, G., Clustering and switching as two components of verbal fluency: evidence from younger and older healthy adults (1997) Neuropsychology, 11 (1), pp. 138-146
  • Vik, P., Ruff, R.R., Children's figural fluency performance: development of strategy use (1988) Dev. Neuropsychol., 4 (1), pp. 63-74
  • Wechsler, D., Wechsler Adult Intelligence Scale-III (1997), The Psychological Corporation San Antonio, TX; Wetter, S.R., Delis, D.C., Houston, W.S., Deficits in inhibition and flexibility are associated with the APOE-E4 allele in nondemented older adults (2005) J. Clin. Exp. Neuropsychol., 27 (8), pp. 943-952
  • Zheng, D., Dong, X., Sun, H., The overall impairment of core executive function components in patients with amnestic mild cognitive impairment: a cross-sectional study (2012) BMC Neurol., 12 (1), p. 138

Citas:

---------- APA ----------
Abulafia, C., Fiorentini, L., Loewenstein, D.A., Curiel-Cid, R., Sevlever, G., Nemeroff, C.B., Villarreal, M.F.,..., Guinjoan, S.M. (2019) . Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients. Journal of Psychiatric Research, 112, 23-29.
http://dx.doi.org/10.1016/j.jpsychires.2019.02.016
---------- CHICAGO ----------
Abulafia, C., Fiorentini, L., Loewenstein, D.A., Curiel-Cid, R., Sevlever, G., Nemeroff, C.B., et al. "Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients" . Journal of Psychiatric Research 112 (2019) : 23-29.
http://dx.doi.org/10.1016/j.jpsychires.2019.02.016
---------- MLA ----------
Abulafia, C., Fiorentini, L., Loewenstein, D.A., Curiel-Cid, R., Sevlever, G., Nemeroff, C.B., et al. "Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients" . Journal of Psychiatric Research, vol. 112, 2019, pp. 23-29.
http://dx.doi.org/10.1016/j.jpsychires.2019.02.016
---------- VANCOUVER ----------
Abulafia, C., Fiorentini, L., Loewenstein, D.A., Curiel-Cid, R., Sevlever, G., Nemeroff, C.B., et al. Executive functioning in cognitively normal middle-aged offspring of late-onset Alzheimer's disease patients. J. Psychiatr. Res. 2019;112:23-29.
http://dx.doi.org/10.1016/j.jpsychires.2019.02.016