Voorsluijs, V.; Dawson, S.P.; De Decker, Y.; Dupont, G. "Deterministic Limit of Intracellular Calcium Spikes" (2019) Physical Review Letters. 122(8)
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In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with experimental data. Combining fully stochastic simulations and mean-field analyses, we demonstrate that these two approaches can be reconciled. Our fully stochastic model generates spike sequences that can be seen as noise-perturbed oscillations of deterministic origin, while displaying statistical properties in agreement with experimental data. These underlying deterministic oscillations arise from a phenomenological spike nucleation mechanism. © 2019 American Physical Society.


Documento: Artículo
Título:Deterministic Limit of Intracellular Calcium Spikes
Autor:Voorsluijs, V.; Dawson, S.P.; De Decker, Y.; Dupont, G.
Filiación:Nonlinear Physical Chemistry Unit, Center for Nonlinear Phenomena and Complex Systems (CENOLI), Université Libre de Bruxelles, Boulevard du Triomphe, C.P. 231, Brussels, B-1050, Belgium
Departamento de Física, FCEN-UBA and IFIBA, UBA-CONICET, Ciudad Universitaria, Pabellón i, Buenos Aires, 1428, Argentina
Unité de Chronobiologie Théorique, Université Libre de Bruxelles, Boulevard du Triomphe, C.P. 231, Brussels, B-1050, Belgium
Título revista:Physical Review Letters
Título revista abreviado:Phys Rev Lett


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---------- APA ----------
Voorsluijs, V., Dawson, S.P., De Decker, Y. & Dupont, G. (2019) . Deterministic Limit of Intracellular Calcium Spikes. Physical Review Letters, 122(8).
---------- CHICAGO ----------
Voorsluijs, V., Dawson, S.P., De Decker, Y., Dupont, G. "Deterministic Limit of Intracellular Calcium Spikes" . Physical Review Letters 122, no. 8 (2019).
---------- MLA ----------
Voorsluijs, V., Dawson, S.P., De Decker, Y., Dupont, G. "Deterministic Limit of Intracellular Calcium Spikes" . Physical Review Letters, vol. 122, no. 8, 2019.
---------- VANCOUVER ----------
Voorsluijs, V., Dawson, S.P., De Decker, Y., Dupont, G. Deterministic Limit of Intracellular Calcium Spikes. Phys Rev Lett. 2019;122(8).