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Abstract:

Water-soluble sulfated polysaccharides from the red seaweed Nemalion helminthoides: two xylomannan fractions (N3 and N4) and a mannan fraction (N6) were investigated to determine their in vitro and in vivo immunomodulatory activities. N3 and N4 induced in vitro proliferation of macrophages of the murine cell line RAW 264.7 and significantly stimulated the production of nitric oxide (NO) and cytokines (IL-6 and TNF-α) in the same cells, whereas this response was not observed with the mannan N6. The cytokine production was also stimulated by sulfated xylomannans in vivo in BALB/c mice inoculated intravenously with these polysaccharides. Remarkably, when mice were treated with N3 and N4 for 1. h before being infected with Herpes simplex virus type 2, they remained asymptomatic with no signs of disease. The in vitro and in vivo results suggest that sulfated xylomannans could be strong immunomodulators. © 2013 Elsevier B.V.

Registro:

Documento: Artículo
Título:In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides
Autor:Pérez-Recalde, M.; Matulewicz, M.C.; Pujol, C.A.; Carlucci, M.J.
Filiación:Departamento de Química Orgánica-CIHIDECAR (CONICET-UBA), Facultad de Ciencias. Exactas y Naturales, UBA, Pabellón 2, Ciudad Universitaria, 1428EGA Buenos Aires, Argentina
Laboratorio de Virología, Departamento de Química Biológica-IQUIBICEN (CONICET-UBA), Facultad de Ciencias Exactas y Naturales UBA, Pabellón 2, Ciudad Universitaria, 1428EGA Buenos Aires, Argentina
Idioma: Inglés
Palabras clave:Immunomodulatory activity; Nemalion helminthoides; Sulfated xylomannans; immunomodulating agent; interleukin 6; mannan; mannan fraction; nitric oxide; polysaccharide sulfate; sulfated mannan; sulfated xylomannan; tumor necrosis factor alpha; unclassified drug; animal cell; animal experiment; animal model; article; cell proliferation; concentration response; controlled study; cytokine production; cytokine release; cytotoxicity; drug activity; herpes simplex; Herpes simplex virus 2; immunomodulation; in vitro study; in vivo study; infection prevention; macrophage; male; mouse; nonhuman; protein blood level; red alga
Año:2014
Volumen:63
Página de inicio:38
Página de fin:42
DOI: http://dx.doi.org/10.1016/j.ijbiomac.2013.10.024
Título revista:International Journal of Biological Macromolecules
Título revista abreviado:Int. J. Biol. Macromol.
ISSN:01418130
CODEN:IJBMD
CAS:mannan, 51395-96-1, 9036-88-8; nitric oxide, 10102-43-9; polysaccharide sulfate, 79933-28-1
Registro:http://digital.bl.fcen.uba.ar/collection/paper/document/paper_01418130_v63_n_p38_PerezRecalde

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Citas:

---------- APA ----------
Pérez-Recalde, M., Matulewicz, M.C., Pujol, C.A. & Carlucci, M.J. (2014) . In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides. International Journal of Biological Macromolecules, 63, 38-42.
http://dx.doi.org/10.1016/j.ijbiomac.2013.10.024
---------- CHICAGO ----------
Pérez-Recalde, M., Matulewicz, M.C., Pujol, C.A., Carlucci, M.J. "In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides" . International Journal of Biological Macromolecules 63 (2014) : 38-42.
http://dx.doi.org/10.1016/j.ijbiomac.2013.10.024
---------- MLA ----------
Pérez-Recalde, M., Matulewicz, M.C., Pujol, C.A., Carlucci, M.J. "In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides" . International Journal of Biological Macromolecules, vol. 63, 2014, pp. 38-42.
http://dx.doi.org/10.1016/j.ijbiomac.2013.10.024
---------- VANCOUVER ----------
Pérez-Recalde, M., Matulewicz, M.C., Pujol, C.A., Carlucci, M.J. In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides. Int. J. Biol. Macromol. 2014;63:38-42.
http://dx.doi.org/10.1016/j.ijbiomac.2013.10.024