Artículo

Salinas, F.M.; Vázquez, L.; Gentilini, M.V.; O´Donohoe, A.; Regueira, E.; Nabaes Jodar, M.S.; Viegas, M.; Michelini, F.M.; Hermida, G.; Alché, L.E.; Bueno, C.A. "Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo" (2019) Antiviral Research. 164:1-11
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Abstract:

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease and bronchiolitis in children worldwide. No vaccine or specific, effective treatment is currently available. β-escin is one of the main bioactive constituents of Aesculus hippocastanum L. (Hippocastanaceae) seed extract (AH), and both β-escin and AH have demonstrated a beneficial role in clinical therapy because of their anti-edematous, anti-inflammatory and antioxidative effects. Besides, we have reported that β-escin and AH show virucidal, antiviral and immunomodulatory activities against the enveloped viruses HSV-1, VSV and Dengue virus in vitro. In this study, we demonstrate that β-escin and AH have virucidal and antiviral activities against RSV, as well as NF-κB, AP-1 and cytokine modulating activities in RSV infected epithelial and macrophage cell lines in vitro. Besides, in a murine model of pulmonary RSV infection, AH treatment improves the course of acute disease, evidenced by decreased weight loss, reduced RSV lung titers, and attenuated airway inflammation. In contrast, even though β-escin showed, similarly to AH, antiviral and immunomodulatory properties in vitro, it neither reduces viral titers nor attenuates lung injury in vivo. Thus, our data demonstrate that AH restrains RSV disease through antiviral and immunomodulatory effect. © 2019 Elsevier B.V.

Registro:

Documento: Artículo
Título:Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo
Autor:Salinas, F.M.; Vázquez, L.; Gentilini, M.V.; O´Donohoe, A.; Regueira, E.; Nabaes Jodar, M.S.; Viegas, M.; Michelini, F.M.; Hermida, G.; Alché, L.E.; Bueno, C.A.
Filiación:Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Virología, Buenos Aires, Argentina
CONICET, Universidad de Buenos Aires, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Buenos Aires, Argentina
Unidad Operativa Centro de Contención Biológica (UOCCB), Administración Nacional de Laboratorios e Institutos de Salud (ANLIS), Argentina
Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMETTYB)-CONICET, Buenos Aires, Argentina
Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Laboratorio de Biología de Anfibios-Histología Animal, Buenos Aires, Argentina
CONICET, Buenos Aires, Argentina
Laboratorio de Virología, Hospital de Niños Ricardo Gutierrez, Buenos Aires, Argentina
Ministerio de Salud de la Ciudad de, Buenos Aires, Argentina
Palabras clave:Aesculus hippocastanum; Antiviral; Immunomodulatory; Medicinal plants; Respiratory syncytial virus (RSV); β-escin; Aesculus hippocastanum extract; beta actin; beta escin; gamma interferon; immunoglobulin enhancer binding protein; interleukin 17; interleukin 4; interleukin 6; interleukin 8; transcription factor AP 1; tumor necrosis factor; virus RNA; Aesculus hippocastanum; animal cell; animal experiment; animal model; animal tissue; antiviral activity; Article; controlled study; epithelium cell; human; human cell; immunomodulation; in vitro study; lung epithelium; lung parenchyma; macrophage; mouse; nonhuman; plant seed; priority journal; respiratory syncytial virus infection; respiratory tract inflammation; RNA replication; signal transduction; Th2 cell; treatment duration; Vero cell line; virucidal activity; virus infectivity; virus load
Año:2019
Volumen:164
Página de inicio:1
Página de fin:11
DOI: http://dx.doi.org/10.1016/j.antiviral.2019.01.018
Título revista:Antiviral Research
Título revista abreviado:Antiviral Res.
ISSN:01663542
CODEN:ARSRD
CAS:beta escin, 64156-26-9; gamma interferon, 82115-62-6; interleukin 8, 114308-91-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01663542_v164_n_p1_Salinas

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Citas:

---------- APA ----------
Salinas, F.M., Vázquez, L., Gentilini, M.V., O´Donohoe, A., Regueira, E., Nabaes Jodar, M.S., Viegas, M.,..., Bueno, C.A. (2019) . Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo. Antiviral Research, 164, 1-11.
http://dx.doi.org/10.1016/j.antiviral.2019.01.018
---------- CHICAGO ----------
Salinas, F.M., Vázquez, L., Gentilini, M.V., O´Donohoe, A., Regueira, E., Nabaes Jodar, M.S., et al. "Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo" . Antiviral Research 164 (2019) : 1-11.
http://dx.doi.org/10.1016/j.antiviral.2019.01.018
---------- MLA ----------
Salinas, F.M., Vázquez, L., Gentilini, M.V., O´Donohoe, A., Regueira, E., Nabaes Jodar, M.S., et al. "Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo" . Antiviral Research, vol. 164, 2019, pp. 1-11.
http://dx.doi.org/10.1016/j.antiviral.2019.01.018
---------- VANCOUVER ----------
Salinas, F.M., Vázquez, L., Gentilini, M.V., O´Donohoe, A., Regueira, E., Nabaes Jodar, M.S., et al. Aesculus hippocastanum L. seed extract shows virucidal and antiviral activities against respiratory syncytial virus (RSV) and reduces lung inflammation in vivo. Antiviral Res. 2019;164:1-11.
http://dx.doi.org/10.1016/j.antiviral.2019.01.018