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Abstract:

De novo ectopic lymphoid tissue formation is known to occur in certain disease and inflammatory settings. After an effective vaccination with dendritic cells (DC) charged with melanoma apoptotic/necrotic cells (Apo/Nec), a subcutaneous tertiary lymphoid structure was organized, where retained vaccine cells interacted with recruited inflammatory and T cells. In this work we report for the first time the recruitment of two morphologically different CD207+ cells to vaccination site. The time-course behavior of CD207+ cells was reciprocal between vaccination site and draining lymph nodes (DLNs). After 6-10 days, CD207+ cells localized at the paracortical region of DLNs, in close contact with T cell population. DLNs were enriched in a peculiar MHCII+ CD11c(-) CD207+ population, whose role remains to be determined. Whether CD207+ cells migration to the vaccination site can be associated with a differential anti-tumoral response remains as an open and exciting question. © 2014 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice
Autor:Ruiz, M.S.; Mac Keon, S.; Campisano, S.; Bravo, A.I.; Gazzaniga, S.; Wainstok, R.
Filiación:Dpto. de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina
Fundación Instituto Leloir, IIBBA CONICET, Buenos Aires, Argentina
Hospital Eva Perón, San Martín, Buenos Aires, Argentina
Idioma: Inglés
Palabras clave:CD207+ cells; Dendritic cells; Ectopic lymphoid tissue; Melanoma; Vaccine
Año:2014
DOI: http://dx.doi.org/10.1016/j.vaccine.2014.01.025
Título revista:Vaccine
Título revista abreviado:Vaccine
ISSN:0264410X
CODEN:VACCD
Registro:http://digital.bl.fcen.uba.ar/collection/paper/document/paper_0264410X_v_n_p_Ruiz

Citas:

---------- APA ----------
Ruiz, M.S., Mac Keon, S., Campisano, S., Bravo, A.I., Gazzaniga, S. & Wainstok, R. (2014) . CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice. Vaccine.
http://dx.doi.org/10.1016/j.vaccine.2014.01.025
---------- CHICAGO ----------
Ruiz, M.S., Mac Keon, S., Campisano, S., Bravo, A.I., Gazzaniga, S., Wainstok, R. "CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice" . Vaccine (2014).
http://dx.doi.org/10.1016/j.vaccine.2014.01.025
---------- MLA ----------
Ruiz, M.S., Mac Keon, S., Campisano, S., Bravo, A.I., Gazzaniga, S., Wainstok, R. "CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice" . Vaccine, 2014.
http://dx.doi.org/10.1016/j.vaccine.2014.01.025
---------- VANCOUVER ----------
Ruiz, M.S., Mac Keon, S., Campisano, S., Bravo, A.I., Gazzaniga, S., Wainstok, R. CD207+ cells recruitment to the vaccination site and draining lymph nodes after the administration of DC-Apo/Nec vaccine in mice. Vaccine. 2014.
http://dx.doi.org/10.1016/j.vaccine.2014.01.025