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IL-6 is a pleiotropic cytokine with multiple pathophysiological functions. As a key factor of the senescence secretome, it can not only promote tumorigenesis and cell proliferation but also exert tumor suppressive functions, depending on the cellular context. IL-6, as do other cytokines, plays important roles in the function, growth and neuroendocrine responses of the anterior pituitary gland. The multiple actions of IL-6 on normal and adenomatous pituitary function, cell proliferation, angiogenesis and extracellular matrix remodeling indicate its importance in the regulation of the anterior pituitary. Pituitary tumors are mostly benign adenomas with low mitotic index and rarely became malignant. Premature senescence occurs in slow-growing benign tumors, like pituitary adenomas. The dual role of IL-6 in senescence and tumorigenesis is well represented in pituitary tumor development, as it has been demonstrated that effects of paracrine IL-6 may allow initial pituitary cell growth, whereas autocrine IL-6 in the same tumor triggers senescence and restrains aggressive growth and malignant transformation. IL-6 is instrumental in promotion and maintenance of the senescence program in pituitary adenomas. © 2017 Society for Endocrinology.


Documento: Artículo
Título:Programmed cell senescence: Role of IL-6 in the pituitary
Autor:Sapochnik, M.; Fuertes, M.; Arzt, E.
Filiación:Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA), CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina
Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Autocrine; IL-6; Pituitary tumor; Senescence; interleukin 6; IL6 protein, human; interleukin 6; mitogen activated protein kinase kinase; phosphatidylinositol 3 kinase; STAT protein; carcinogenesis; cell aging; cell growth; human; hypophysis; hypophysis adenoma; hypophysis cell; hypophysis tumor; malignant transformation; molecular pathology; nonhuman; paracrine signaling; priority journal; protein function; Review; adenohypophysis; adenoma; animal; autocrine effect; cell aging; cell cycle; cell proliferation; extracellular matrix; gene expression regulation; genetics; metabolism; neovascularization (pathology); pathology; Adenoma; Animals; Autocrine Communication; Cell Cycle; Cell Proliferation; Cellular Senescence; Extracellular Matrix; Gene Expression Regulation; Humans; Interleukin-6; Mitogen-Activated Protein Kinase Kinases; Neovascularization, Pathologic; Paracrine Communication; Phosphatidylinositol 3-Kinases; Pituitary Gland, Anterior; Pituitary Neoplasms; STAT Transcription Factors
Página de inicio:R241
Página de fin:R253
Título revista:Journal of Molecular Endocrinology
Título revista abreviado:J. Mol. Endocrinol.
CAS:mitogen activated protein kinase kinase, 142805-58-1; phosphatidylinositol 3 kinase, 115926-52-8; IL6 protein, human; Interleukin-6; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; STAT Transcription Factors


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---------- APA ----------
Sapochnik, M., Fuertes, M. & Arzt, E. (2017) . Programmed cell senescence: Role of IL-6 in the pituitary. Journal of Molecular Endocrinology, 58(4), R241-R253.
---------- CHICAGO ----------
Sapochnik, M., Fuertes, M., Arzt, E. "Programmed cell senescence: Role of IL-6 in the pituitary" . Journal of Molecular Endocrinology 58, no. 4 (2017) : R241-R253.
---------- MLA ----------
Sapochnik, M., Fuertes, M., Arzt, E. "Programmed cell senescence: Role of IL-6 in the pituitary" . Journal of Molecular Endocrinology, vol. 58, no. 4, 2017, pp. R241-R253.
---------- VANCOUVER ----------
Sapochnik, M., Fuertes, M., Arzt, E. Programmed cell senescence: Role of IL-6 in the pituitary. J. Mol. Endocrinol. 2017;58(4):R241-R253.