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Immune checkpoints, a plethora of inhibitory pathways aimed at maintaining immune cell homeostasis, may be co-opted by cancer cells to evade immune destruction. Therapies targeting immune checkpoints have reached a momentum yielding significant clinical benefits in patients with various malignancies by unleashing anti-tumor immunity. Galectins, a family of glycan-binding proteins, have emerged as novel regulatory checkpoints that promote immune evasive programs by inducing T-cell exhaustion, limiting T-cell survival, favoring expansion of regulatory T cells, de-activating natural killer cells and polarizing myeloid cells toward an immunosuppressive phenotype. Concomitantly, galectins can trigger vascular signaling programs, serving as bifunctional messengers that couple tumor immunity and angiogenesis. Thus, targeting galectin–glycan interactions may halt tumor progression by simultaneously augmenting antitumor immunity and suppressing aberrant angiogenesis. © 2017 Elsevier Ltd


Documento: Artículo
Título:Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis
Autor:Méndez-Huergo, S.P.; Blidner, A.G.; Rabinovich, G.A.
Filiación:Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, C1428, Argentina
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, C1428, Argentina
Palabras clave:galectin; glycan; galectin; bone marrow cell; carcinogenesis; CD4+ T lymphocyte; cell differentiation; gene expression profiling; glioblastoma; glycosylation; human; immunomodulation; immunoregulation; internalization; Kaposi sarcoma; natural killer cell; oligomerization; protein binding; protein domain; protein protein interaction; regulatory T lymphocyte; Review; signal transduction; T lymphocyte; tumor associated leukocyte; tumor immunity; animal; immunology; neoplasm; neovascularization (pathology); pathology; vascularization; Animals; Galectins; Humans; Killer Cells, Natural; Neoplasms; Neovascularization, Pathologic; T-Lymphocytes
Página de inicio:8
Página de fin:15
Título revista:Current Opinion in Immunology
Título revista abreviado:Curr. Opin. Immunol.


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---------- APA ----------
Méndez-Huergo, S.P., Blidner, A.G. & Rabinovich, G.A. (2017) . Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis. Current Opinion in Immunology, 45, 8-15.
---------- CHICAGO ----------
Méndez-Huergo, S.P., Blidner, A.G., Rabinovich, G.A. "Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis" . Current Opinion in Immunology 45 (2017) : 8-15.
---------- MLA ----------
Méndez-Huergo, S.P., Blidner, A.G., Rabinovich, G.A. "Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis" . Current Opinion in Immunology, vol. 45, 2017, pp. 8-15.
---------- VANCOUVER ----------
Méndez-Huergo, S.P., Blidner, A.G., Rabinovich, G.A. Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis. Curr. Opin. Immunol. 2017;45:8-15.