Artículo

González, B.; Bernardi, A.; Torres, O.V.; Jayanthi, S.; Gomez, N.; Sosa, M.H.; García-Rill, E.; Urbano, F.J.; Cadet, J.-L.; Bisagno, V."HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex" (2019) Addiction Biology
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Abstract:

Dysregulation of histone deacetylases (HDAC) has been proposed as a potential contributor to aberrant transcriptional profiles that can lead to changes in cognitive functions. It is known that METH negatively impacts the prefrontal cortex (PFC) leading to cognitive decline and addiction whereas modafinil enhances cognition and has a low abuse liability. We investigated if modafinil (90 mg/kg) and methamphetmine (METH) (1 mg/kg) may differentially influence the acetylation status of histones 3 and 4 (H3ac and H4ac) at proximal promoters of class I, II, III, and IV HDACs. We found that METH produced broader acetylation effects in comparison with modafinil in the medial PFC. For single dose, METH affected H4ac by increasing its acetylation at class I Hdac1 and class IIb Hdac10, decreasing it at class IIa Hdac4 and Hdac5. Modafinil increased H3ac and decreased H4ac of Hdac7. For mRNA, single-dose METH increased Hdac4 and modafinil increased Hdac7 expression. For repeated treatments (4 d after daily injections over 7 d), we found specific effects only for METH. We found that METH increased H4ac in class IIa Hdac4 and Hdac5 and decreased H3/H4ac at class I Hdac1, Hdac2, and Hdac8. At the mRNA level, repeated METH increased Hdac4 and decreased Hdac2. Class III and IV HDACs were only responsive to repeated treatments, where METH affected the H3/H4ac status of Sirt2, Sirt3, Sirt7, and Hdac11. Our results suggest that HDAC targets linked to the effects of modafinil and METH may be related to the cognitive-enhancing vs cognitive-impairing effects of these psychostimulants. © 2019 Society for the Study of Addiction

Registro:

Documento: Artículo
Título:HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex
Autor:González, B.; Bernardi, A.; Torres, O.V.; Jayanthi, S.; Gomez, N.; Sosa, M.H.; García-Rill, E.; Urbano, F.J.; Cadet, J.-L.; Bisagno, V.
Filiación:Instituto de Investigaciones Farmacológicas, Universidad de Buenos Aires – Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
Department of Behavioral Sciences, San Diego Mesa College, San Diego, CA, United States
Molecular Neuropsychiatry Research Branch, NIH/NIDA Intramural Research Program, Baltimore, MD, United States
Center for Translational Neuroscience, Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States
Laboratorio de Fisiología y Biología Molecular, Instituto de Fisiología, Biología Molecular y Neurociencias, Universidad de Buenos Aires – Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina
Palabras clave:HDAC; histone acetylation; methamphetamine; modafinil; prefrontal cortex
Año:2019
DOI: http://dx.doi.org/10.1111/adb.12737
Handle:http://hdl.handle.net/20.500.12110/paper_13556215_v_n_p_Gonzalez
Título revista:Addiction Biology
Título revista abreviado:Addict. Biol.
ISSN:13556215
CODEN:ADBIF
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13556215_v_n_p_Gonzalez

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Citas:

---------- APA ----------
González, B., Bernardi, A., Torres, O.V., Jayanthi, S., Gomez, N., Sosa, M.H., García-Rill, E.,..., Bisagno, V. (2019) . HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex. Addiction Biology.
http://dx.doi.org/10.1111/adb.12737
---------- CHICAGO ----------
González, B., Bernardi, A., Torres, O.V., Jayanthi, S., Gomez, N., Sosa, M.H., et al. "HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex" . Addiction Biology (2019).
http://dx.doi.org/10.1111/adb.12737
---------- MLA ----------
González, B., Bernardi, A., Torres, O.V., Jayanthi, S., Gomez, N., Sosa, M.H., et al. "HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex" . Addiction Biology, 2019.
http://dx.doi.org/10.1111/adb.12737
---------- VANCOUVER ----------
González, B., Bernardi, A., Torres, O.V., Jayanthi, S., Gomez, N., Sosa, M.H., et al. HDAC superfamily promoters acetylation is differentially regulated by modafinil and methamphetamine in the mouse medial prefrontal cortex. Addict. Biol. 2019.
http://dx.doi.org/10.1111/adb.12737