Artículo

Calienni, M.N.; Lillo, C.R.; Prieto, M.J.; Gorojod, R.M.; Alonso, S.D.V.; Kotler, M.L.; Gonzalez, M.C.; Montanari, J. "Comparative toxicity of PEG and folate-derived blue-emitting silicon nanoparticles: In vitro and in vivo studies" (2019) Nanomedicine. 14(4):375-385
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Abstract:

Aim: Amino functionalization is a first step modification aiming to achieve biomedical applications of silicon nanoparticles, for example, for photodynamic therapy or radiotherapy. Nevertheless, toxicity and low quantum yields due to the positive charge of amino groups emerge as a problem that could be solved with subsequent derivatizations. Materials & methods: Folic and PEG-conjugated nanoparticles were obtained from amino-functionalized silicon nanoparticle (NH 2 SiNP). Cytotoxicity was determined on a tumor cell line at low and high concentrations. Four end points of in vivo toxicity were evaluated on zebrafish (Danio rerio). Results: Folic acid functionalization reduced the cytotoxicity in comparison to amino and PEG-functionalized nanoparticles. In zebrafish, folic functionalization lowered toxicity in general while PEG increased it. Conclusion: Functionalization of NH 2 SiNP with folic acid reduced the toxic effects in vitro and in vivo. This could be useful for therapeutic applications. PEG functionalization did not lower the toxicity. © 2019 2019 Future Medicine Ltd.

Registro:

Documento: Artículo
Título:Comparative toxicity of PEG and folate-derived blue-emitting silicon nanoparticles: In vitro and in vivo studies
Autor:Calienni, M.N.; Lillo, C.R.; Prieto, M.J.; Gorojod, R.M.; Alonso, S.D.V.; Kotler, M.L.; Gonzalez, M.C.; Montanari, J.
Filiación:Laboratorio de Biomembranas - GBEyB (IMBICE CCT-La Plata, CONICET), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, 1876, Argentina
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), CCT-La Plata-CONICET, Universidad Nacional de La Plata, La Plata, 1900, Argentina
Instituto de Nanosistemas (INS), Universidad Nacional de San Martin, San-Martín, 1650, Argentina
CONICET-Universidad de Buenos Aires, Instituto de Química Biológica Ciencias Exactas y Naturales (IQUIBICEN), Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Disfunción Celular en Enfermedades Neurodegenerativas y Nanomedicina, Ciudad Autónoma de Buenos Aires, 1428, Argentina
Palabras clave:folic acid; silicon nanoparticles; zebrafish
Año:2019
Volumen:14
Número:4
Página de inicio:375
Página de fin:385
DOI: http://dx.doi.org/10.2217/nnm-2018-0251
Título revista:Nanomedicine
Título revista abreviado:Nanomedicine
ISSN:17435889
Registro:http://digital.bl.fcen.uba.ar/collection/paper/document/paper_17435889_v14_n4_p375_Calienni

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Citas:

---------- APA ----------
Calienni, M.N., Lillo, C.R., Prieto, M.J., Gorojod, R.M., Alonso, S.D.V., Kotler, M.L., Gonzalez, M.C.,..., Montanari, J. (2019) . Comparative toxicity of PEG and folate-derived blue-emitting silicon nanoparticles: In vitro and in vivo studies. Nanomedicine, 14(4), 375-385.
http://dx.doi.org/10.2217/nnm-2018-0251
---------- CHICAGO ----------
Calienni, M.N., Lillo, C.R., Prieto, M.J., Gorojod, R.M., Alonso, S.D.V., Kotler, M.L., et al. "Comparative toxicity of PEG and folate-derived blue-emitting silicon nanoparticles: In vitro and in vivo studies" . Nanomedicine 14, no. 4 (2019) : 375-385.
http://dx.doi.org/10.2217/nnm-2018-0251
---------- MLA ----------
Calienni, M.N., Lillo, C.R., Prieto, M.J., Gorojod, R.M., Alonso, S.D.V., Kotler, M.L., et al. "Comparative toxicity of PEG and folate-derived blue-emitting silicon nanoparticles: In vitro and in vivo studies" . Nanomedicine, vol. 14, no. 4, 2019, pp. 375-385.
http://dx.doi.org/10.2217/nnm-2018-0251
---------- VANCOUVER ----------
Calienni, M.N., Lillo, C.R., Prieto, M.J., Gorojod, R.M., Alonso, S.D.V., Kotler, M.L., et al. Comparative toxicity of PEG and folate-derived blue-emitting silicon nanoparticles: In vitro and in vivo studies. Nanomedicine. 2019;14(4):375-385.
http://dx.doi.org/10.2217/nnm-2018-0251