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Abstract:

Although the phosphorus atom is found in a variety of oxidation states, most of the phosphorus-containing molecules of pharmacological importance possess phosphorus in the form of phosphonate or phosphinate functional groups, or in a major oxidation state as a phosphate group. The most common occurrence of phosphorus in drugs is either in prodrugs or in compounds for which the phosphorus atom plays a role in the biological activity, such as in modified nucleotides, in metabolically stable analogues of metabolites bearing phosphate groups, and as bioisosteric analogues of carboxyl groups. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Registro:

Documento: Artículo
Título:The Role of the Phosphorus Atom in Drug Design
Autor:Rodriguez, J.B.; Gallo-Rodriguez, C.
Filiación:Departamento de Química Orgánica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, C1428EHA, Argentina
Departamento de Química Orgánica and CIHIDECAR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, C1428EHA, Argentina
Palabras clave:bisphosphonates; nucleotides; organophosphorus compounds; phosphorus; prodrugs; bisphosphonic acid derivative; geranyltransferase; heterocyclic compound; miscellaneous drugs and agents; nucleotide; phosphorus derivative; prodrug; squalene synthase; atom; drug conjugation; drug design; drug structure; drug targeting; human; molecular weight; nonhuman; priority journal; Review
Año:2019
Volumen:14
Número:2
Página de inicio:190
Página de fin:216
DOI: http://dx.doi.org/10.1002/cmdc.201800693
Título revista:ChemMedChem
Título revista abreviado:ChemMedChem
ISSN:18607179
CODEN:CHEMG
CAS:geranyltransferase, 37277-79-5, 50812-36-7; squalene synthase, 9077-14-9
Registro:http://digital.bl.fcen.uba.ar/collection/paper/document/paper_18607179_v14_n2_p190_Rodriguez

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Citas:

---------- APA ----------
Rodriguez, J.B. & Gallo-Rodriguez, C. (2019) . The Role of the Phosphorus Atom in Drug Design. ChemMedChem, 14(2), 190-216.
http://dx.doi.org/10.1002/cmdc.201800693
---------- CHICAGO ----------
Rodriguez, J.B., Gallo-Rodriguez, C. "The Role of the Phosphorus Atom in Drug Design" . ChemMedChem 14, no. 2 (2019) : 190-216.
http://dx.doi.org/10.1002/cmdc.201800693
---------- MLA ----------
Rodriguez, J.B., Gallo-Rodriguez, C. "The Role of the Phosphorus Atom in Drug Design" . ChemMedChem, vol. 14, no. 2, 2019, pp. 190-216.
http://dx.doi.org/10.1002/cmdc.201800693
---------- VANCOUVER ----------
Rodriguez, J.B., Gallo-Rodriguez, C. The Role of the Phosphorus Atom in Drug Design. ChemMedChem. 2019;14(2):190-216.
http://dx.doi.org/10.1002/cmdc.201800693