Artículo

Luce, L.N.; Abbate, M.; Cotignola, J.; Giliberto, F."Non-myogenic tumors display altered expression of dystrophin (DMD) and a high frequency of genetic alterations" (2017) Oncotarget. 8(1):145-155
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Abstract:

DMD gene mutations have been associated with the development of Dystrophinopathies. Interestingly, it has been recently reported that DMD is involved in the development and progression of myogenic tumors, assigning DMD a tumor suppressor activity in these types of cancer. However, there are only few reports that analyze DMD in non-myogenic tumors. Our study was designed to examine DMD expression and genetic alterations in non-myogenic tumors using public repositories. We also evaluated the overall survival of patients with and without DMD mutations. We studied 59 gene expression microarrays (GEO database) and RNAseq (cBioPortal) datasets that included 9817 human samples. We found reduced DMD expression in 15/27 (56%) pairwise comparisons performed (Fold-Change (FC) ≤ 0.70; p-value range = 0.04-1.5x10-20). The analysis of RNAseq studies revealed a median frequency of DMD genetic alterations of 3.4%, higher or similar to other well-known tumor suppressor genes. In addition, we observed significant poorer overall survival for patients with DMD mutations. The analyses of paired tumor/normal tissues showed that the majority of tumor specimens had lower DMD expression compared to their normal adjacent counterpart. Interestingly, statistical significant over-expression of DMD was found in 6/27 studies (FC ≥ 1.4; p-value range = 0.03-3.4x10-15). These results support that DMD expression and genetic alterations are frequent and relevant in non-myogenic tumors. The study and validation of DMD as a new player in tumor development and as a new prognostic factor for tumor progression and survival are warranted.

Registro:

Documento: Artículo
Título:Non-myogenic tumors display altered expression of dystrophin (DMD) and a high frequency of genetic alterations
Autor:Luce, L.N.; Abbate, M.; Cotignola, J.; Giliberto, F.
Filiación:INIGEM, CONICET/Cátedra de Genética y Biología Molecular, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina
IQUIBICEN, CONICET/Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Palabras clave:DMD; Dystrophin; Gene expression; Genetic alteration; Survival; dystrophin; Article; benign neoplasm; breast cancer; cancer growth; cancer prognosis; cancer survival; controlled study; disease association; DMD gene; gene expression regulation; gene identification; gene mutation; gene overexpression; genetic association; genetic disorder; microarray analysis; mutational analysis; non myogenic tumor; overall survival; RNA sequence; survival rate; survival time; tumor suppressor gene; uterus cancer
Año:2017
Volumen:8
Número:1
Página de inicio:145
Página de fin:155
DOI: http://dx.doi.org/10.18632/oncotarget.10426
Handle:http://hdl.handle.net/20.500.12110/paper_19492553_v8_n1_p145_Luce
Título revista:Oncotarget
Título revista abreviado:Oncotarget
ISSN:19492553
CAS:dystrophin, 116978-02-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19492553_v8_n1_p145_Luce

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Citas:

---------- APA ----------
Luce, L.N., Abbate, M., Cotignola, J. & Giliberto, F. (2017) . Non-myogenic tumors display altered expression of dystrophin (DMD) and a high frequency of genetic alterations. Oncotarget, 8(1), 145-155.
http://dx.doi.org/10.18632/oncotarget.10426
---------- CHICAGO ----------
Luce, L.N., Abbate, M., Cotignola, J., Giliberto, F. "Non-myogenic tumors display altered expression of dystrophin (DMD) and a high frequency of genetic alterations" . Oncotarget 8, no. 1 (2017) : 145-155.
http://dx.doi.org/10.18632/oncotarget.10426
---------- MLA ----------
Luce, L.N., Abbate, M., Cotignola, J., Giliberto, F. "Non-myogenic tumors display altered expression of dystrophin (DMD) and a high frequency of genetic alterations" . Oncotarget, vol. 8, no. 1, 2017, pp. 145-155.
http://dx.doi.org/10.18632/oncotarget.10426
---------- VANCOUVER ----------
Luce, L.N., Abbate, M., Cotignola, J., Giliberto, F. Non-myogenic tumors display altered expression of dystrophin (DMD) and a high frequency of genetic alterations. Oncotarget. 2017;8(1):145-155.
http://dx.doi.org/10.18632/oncotarget.10426