Artículo

Gentilini, L.D.; Jaworski, F.M.; Tiraboschi, C.; Pérez, I.G.; Kotler, M.L.; Chauchereau, A.; Laderach, D.J.; Compagno, D. "Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer" (2017) Oncotarget. 8(27):44654-44668
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Abstract:

Two decades ago, Galectin-8 was described as a prostate carcinoma biomarker since it is only expressed in the neoplastic prostate, but not in the healthy tissue. To date, no biological function has been attributed to Galectin-8 that could explain this differential expression. In this study we silenced Galectin-8 in two human prostate cancer cell lines, PC3 and IGR-CaP1, and designed a pre-clinical experimental model that allows monitoring the pathology from its early steps to the long-term metastatic stages. We show for the first time that the natural and conserved expression of Gal-8 in tumour cells is responsible for the metastatic evolution of prostate cancer. In fact, Gal-8 controls the rearrangement of the cytoskeleton and E-Cadherin expression, with a major impact on anoikis and homotypic aggregation of tumour cells, both being essential processes for the survival of circulating tumour cells during metastasis. While localized prostate cancer can be cured, metastatic and advanced disease remains a significant therapeutic challenge, urging for the identification of prognostic markers of the metastatic process. Collectively, our results highlight Galectin-8 as a potential target for anti-metastatic therapy against prostate cancer.

Registro:

Documento: Artículo
Título:Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer
Autor:Gentilini, L.D.; Jaworski, F.M.; Tiraboschi, C.; Pérez, I.G.; Kotler, M.L.; Chauchereau, A.; Laderach, D.J.; Compagno, D.
Filiación:Molecular and Functional Glyco-Oncology Laboratory, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
Laboratorio de Disfunción Celular en Enfermedades Neurodegenerativas y Nanomedicina, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
Institut Gustave Roussy-INSERM U981, Villejuif, France
Departamento de Ciencias Básicas, Universidad Nacional de Luján, Luján, Argentina
Palabras clave:Anoikis resistance; Galectins; Metastasis; Prostate cancer; Tumour microenvironment; galectin 8; messenger RNA; uvomorulin; actin filament; animal experiment; animal model; animal tissue; anoikis; Article; carcinogenesis; cell adhesion; cell aggregation; cell migration; cell proliferation; cell survival; circulating tumor cell; controlled study; endothelium cell; filopodium; human; human cell; inguinal lymph node; lymph node metastasis; male; metastasis; mouse; nonhuman; prostate cancer; prostate cancer cell line; protein expression
Año:2017
Volumen:8
Número:27
Página de inicio:44654
Página de fin:44668
DOI: http://dx.doi.org/10.18632/oncotarget.17963
Título revista:Oncotarget
Título revista abreviado:Oncotarget
ISSN:19492553
CAS:galectin 8, 220452-97-1; uvomorulin, 112956-45-3
Registro:http://digital.bl.fcen.uba.ar/collection/paper/document/paper_19492553_v8_n27_p44654_Gentilini

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Citas:

---------- APA ----------
Gentilini, L.D., Jaworski, F.M., Tiraboschi, C., Pérez, I.G., Kotler, M.L., Chauchereau, A., Laderach, D.J.,..., Compagno, D. (2017) . Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer. Oncotarget, 8(27), 44654-44668.
http://dx.doi.org/10.18632/oncotarget.17963
---------- CHICAGO ----------
Gentilini, L.D., Jaworski, F.M., Tiraboschi, C., Pérez, I.G., Kotler, M.L., Chauchereau, A., et al. "Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer" . Oncotarget 8, no. 27 (2017) : 44654-44668.
http://dx.doi.org/10.18632/oncotarget.17963
---------- MLA ----------
Gentilini, L.D., Jaworski, F.M., Tiraboschi, C., Pérez, I.G., Kotler, M.L., Chauchereau, A., et al. "Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer" . Oncotarget, vol. 8, no. 27, 2017, pp. 44654-44668.
http://dx.doi.org/10.18632/oncotarget.17963
---------- VANCOUVER ----------
Gentilini, L.D., Jaworski, F.M., Tiraboschi, C., Pérez, I.G., Kotler, M.L., Chauchereau, A., et al. Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer. Oncotarget. 2017;8(27):44654-44668.
http://dx.doi.org/10.18632/oncotarget.17963