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Abstract:

We report the synthesis of a near-infrared (NIR) fluorescent pH probe with a remarkable Stokes shift (∼135 nm) based on a tricarbocyanine (Cy-PIP). The fluorescent molecule was anchored to SiO2 nanoparticles (Cy-PIP@SiO2) and is capable of monitoring pH changes within the physiological range (pH 6-8). The Cy-PIP@SiO2 nanoparticles were successfully internalized by HeLa cells as shown by fluorescence confocal microscopy, while flow cytometry revealed pH fluctuations during the endocytic pathway. © 2017 The Royal Society of Chemistry.

Registro:

Documento: Artículo
Título:A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: Performance in vitro and in live cells
Autor:Toum Terrones, Y.; Coluccio Leskow, F.; Bordoni, A.V.; Acebedo, S.L.; Spagnuolo, C.C.; Wolosiuk, A.
Filiación:Gerencia Química-Centro Atómico Constituyentes, Comisión Nacional de Energía Atómica, CONICET, Av. Gral. Paz 1499, San Martín, Buenos Aires, B1650KNA, Argentina
Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Cdad. Universitaria, Cdad. Autónoma de Buenos Aires, 1er piso Pabellón IIC1428EGA, Argentina
IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Cdad. Universitaria, Cdad. Autónoma de Buenos Aires, 2do piso Pabellón IIC1428EGA, Argentina
Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Qca. Orgánica, Int. Güiraldes 2160, Buenos Aires, 1428, Argentina
CONICET-Universidad de Buenos Aires, Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR), Int. Güiraldes 2160, Buenos Aires, 1428, Argentina
Palabras clave:Infrared devices; Nanoparticles; Silica; Endocytic pathways; Fluorescence confocal microscopy; Fluorescent molecules; Fluorescent pH probes; Near-infrared fluorescence; pH fluctuations; Physiological range; SiO2 Nanoparticles; Fluorescence
Año:2017
Volumen:5
Número:22
Página de inicio:4031
Página de fin:4034
DOI: http://dx.doi.org/10.1039/c7tb00622e
Título revista:Journal of Materials Chemistry B
Título revista abreviado:J. Mater. Chem. B
ISSN:20507518
CODEN:JMCBD
Registro:http://digital.bl.fcen.uba.ar/collection/paper/document/paper_20507518_v5_n22_p4031_ToumTerrones

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Citas:

---------- APA ----------
Toum Terrones, Y., Coluccio Leskow, F., Bordoni, A.V., Acebedo, S.L., Spagnuolo, C.C. & Wolosiuk, A. (2017) . A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: Performance in vitro and in live cells. Journal of Materials Chemistry B, 5(22), 4031-4034.
http://dx.doi.org/10.1039/c7tb00622e
---------- CHICAGO ----------
Toum Terrones, Y., Coluccio Leskow, F., Bordoni, A.V., Acebedo, S.L., Spagnuolo, C.C., Wolosiuk, A. "A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: Performance in vitro and in live cells" . Journal of Materials Chemistry B 5, no. 22 (2017) : 4031-4034.
http://dx.doi.org/10.1039/c7tb00622e
---------- MLA ----------
Toum Terrones, Y., Coluccio Leskow, F., Bordoni, A.V., Acebedo, S.L., Spagnuolo, C.C., Wolosiuk, A. "A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: Performance in vitro and in live cells" . Journal of Materials Chemistry B, vol. 5, no. 22, 2017, pp. 4031-4034.
http://dx.doi.org/10.1039/c7tb00622e
---------- VANCOUVER ----------
Toum Terrones, Y., Coluccio Leskow, F., Bordoni, A.V., Acebedo, S.L., Spagnuolo, C.C., Wolosiuk, A. A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: Performance in vitro and in live cells. J. Mater. Chem. B. 2017;5(22):4031-4034.
http://dx.doi.org/10.1039/c7tb00622e