Artículo
Zayat, L.; Calero, C.; Alborés, P.; Baraldo, L.; Etchenique, R. "A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage" (2003) Journal of the American Chemical Society. 125(4):882-883
Consulte la política de Acceso Abierto del editor
Abstract:
A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed. Copyright © 2003 American Chemical Society.
Registro:
| Documento: | Artículo |
| Título: | A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage |
| Autor: | Zayat, L.; Calero, C.; Alborés, P.; Baraldo, L.; Etchenique, R. |
| Filiación: | Departamento de Quimica Inorganico, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2, AR1428EHA Buenos Aires, Argentina |
| Palabras clave: | 4 aminopyridine; ligand; metal complex; ruthenium complex; xenon; action potential; animal cell; animal experiment; animal model; article; cell activity; controlled study; covalent bond; crystallization; diode; leech; light absorption; membrane permeability; membrane potential; nerve cell; neurochemistry; nonhuman; nuclear magnetic resonance spectroscopy; oxidation reduction potential; photoactivation; photochemistry; quantum yield; synthesis; 2,2'-Dipyridyl; 4-Aminopyridine; Action Potentials; Animals; Drug Carriers; Ganglia; Leeches; Membrane Potentials; Neurons; Organometallic Compounds; Oxidation-Reduction; Photochemistry; Potassium Channel Blockers |
| Año: | 2003 |
| Volumen: | 125 |
| Número: | 4 |
| Página de inicio: | 882 |
| Página de fin: | 883 |
| DOI: | http://dx.doi.org/10.1021/ja0278943 |
| Título revista: | Journal of the American Chemical Society |
| Título revista abreviado: | J. Am. Chem. Soc. |
| ISSN: | 00027863 |
| CODEN: | JACSA |
| CAS: | 4 aminopyridine, 1003-40-3, 504-24-5; xenon, 7440-63-3; 2,2'-Dipyridyl, 366-18-7; 4-Aminopyridine, 504-24-5; Drug Carriers; Organometallic Compounds; Potassium Channel Blockers; dichlorobis(2,2'-bipyridine)(4-aminopyridine)ruthenium |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00027863_v125_n4_p882_Zayat |
Referencias:
- Adams, S.R., Tsien, R.Y., (1993) Annu. Rev. Physiol., 55, pp. 755-784
- Nicholls, J.G., Wallace, B., Fuchs, P.A., Martin, A.R., (2001) From Neuron to Brain, 4th Ed., , Sinauer Assoc: Sunderland, MA
- Givens, R.S., Weber, J.F.W., Conrad P.G. II, Orosz, G., Donahue, S.L., Thayer, S.A., (2000) J. Am. Chem. Soc., 122, pp. 2687-2697
- Balzani, V., Carassitti, V., (1970) Photochemistry of Coordination Compounds, , Academic Press: New York
- Velez, P., Gyorke, S., Escobar, A.L., Vergara, J., Fill, M., (1997) Biophys. J., 72, pp. 691-697
- De Leo, M., Ford, P.C., (1999) J. Am. Chem. Soc., 121, pp. 1980-1981
- Muller, M., Dierkes, P.W., Schlue, W.-R., (1999) Brain Res., 826, pp. 63-73
- Chun-Ying, D., Zhon-Lin, L., Xiao-Zeng, Y., Mak, T.C.W., (1999) J. Coord. Chem., 46, pp. 301-312
- Pinnick, D.V., Durham, B., (1984) Inorg. Chem., 23, pp. 1440-1445
- Dodsworth, E.S., Lever, A.B.P., (1986) Chem. Phys. Lett., 124, pp. 152-158
- Schlue, W.-R., Deitmer, J., (1980) J. Exp. Biol., 82, pp. 23-34
- Franz, A., Ronacher, B., (2002) J. Comput. Physiol. A, 188, pp. 261-271
Citas:
---------- APA ----------
Zayat, L., Calero, C., Alborés, P., Baraldo, L. & Etchenique, R. (2003) . A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. Journal of the American Chemical Society, 125(4), 882-883.http://dx.doi.org/10.1021/ja0278943
---------- CHICAGO ----------
Zayat, L., Calero, C., Alborés, P., Baraldo, L., Etchenique, R. "A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage" . Journal of the American Chemical Society 125, no. 4 (2003) : 882-883.http://dx.doi.org/10.1021/ja0278943
---------- MLA ----------
Zayat, L., Calero, C., Alborés, P., Baraldo, L., Etchenique, R. "A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage" . Journal of the American Chemical Society, vol. 125, no. 4, 2003, pp. 882-883.http://dx.doi.org/10.1021/ja0278943
---------- VANCOUVER ----------
Zayat, L., Calero, C., Alborés, P., Baraldo, L., Etchenique, R. A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J. Am. Chem. Soc. 2003;125(4):882-883.http://dx.doi.org/10.1021/ja0278943
