Artículo
Keizer, J.; Smith, G.D.; Ponce-Dawson, S.; Pearson, J.E. "Saltatory propagation of Ca2+ waves by Ca2+ sparks" (1998) Biophysical Journal. 75(2):595-600
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Abstract:
Punctate releases of Ca2+, called Ca2+ sparks, originate at the regular array of t-tubules in cardiac myocytes and skeletal muscle. During Ca2+ overload sparks serve as sites for the initiation and propagation of Ca2+ waves in myocytes. Computer simulations of spark-mediated waves are performed with model release sites that reproduce the adaptive Ca2+ release observed for the ryanodine receptor. The speed of these waves is proportional to the diffusion constant of Ca2+, D, rather than √D, as is true for reaction-diffusion equations in a continuous excitable medium. A simplified 'fire-diffuse-fire' model that mimics the properties of Ca2+-induced Ca2+ release (CICR) from isolated sites is used to explain this saltatory mode of wave propagation. Saltatory and continuous wave propagation can be differentiated by the temperature arid Ca2+ buffer dependence of wave speed.
Registro:
| Documento: | Artículo |
| Título: | Saltatory propagation of Ca2+ waves by Ca2+ sparks |
| Autor: | Keizer, J.; Smith, G.D.; Ponce-Dawson, S.; Pearson, J.E. |
| Filiación: | Institute of Theoretical Dynamics, Sect. Neurbio., Physiol., and Behav., University of California, Davis, CA 95616, United States Mathematical Research Branch, Natl. Inst. Diabet. Digest. K., National Intitutes of Health, Bethesda, MD 20814, United States Departmento de Fis. and I. A. F. E, Fac. de Ciencias Exactas y Naturales, Cuidad Universitaria, Pabellón I, 1428 Buenos Aires, Argentina Appl. Theor. and Compl. Physics, Los Alamos National Laboratory, XCM, Los Alamos, NM 87545, United States Institute of Theoretical Dynamics, University of California-Davis, 2201 Academic Surge Bldg., One Shields Avenue, Davis, CA 95616-8618, United States |
| Palabras clave: | article; calcium transport; computer simulation; diffusion coefficient; fluorescence; heart muscle cell; nonhuman; skeletal muscle; transverse tubular system; animal; biological model; cell membrane; diffusion; heart muscle; kinetics; metabolism; skeletal muscle; calcium; ryanodine receptor; Animals; Calcium; Cell Membrane; Computer Simulation; Diffusion; Kinetics; Models, Biological; Muscle, Skeletal; Myocardium; Ryanodine Receptor Calcium Release Channel |
| Año: | 1998 |
| Volumen: | 75 |
| Número: | 2 |
| Página de inicio: | 595 |
| Página de fin: | 600 |
| DOI: | http://dx.doi.org/10.1016/S0006-3495(98)77550-2 |
| Título revista: | Biophysical Journal |
| Título revista abreviado: | Biophys. J. |
| ISSN: | 00063495 |
| CODEN: | BIOJA |
| CAS: | Calcium, 7440-70-2; Ryanodine Receptor Calcium Release Channel |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063495_v75_n2_p595_Keizer |
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Citas:
---------- APA ----------
Keizer, J., Smith, G.D., Ponce-Dawson, S. & Pearson, J.E. (1998) . Saltatory propagation of Ca2+ waves by Ca2+ sparks. Biophysical Journal, 75(2), 595-600.http://dx.doi.org/10.1016/S0006-3495(98)77550-2
---------- CHICAGO ----------
Keizer, J., Smith, G.D., Ponce-Dawson, S., Pearson, J.E. "Saltatory propagation of Ca2+ waves by Ca2+ sparks" . Biophysical Journal 75, no. 2 (1998) : 595-600.http://dx.doi.org/10.1016/S0006-3495(98)77550-2
---------- MLA ----------
Keizer, J., Smith, G.D., Ponce-Dawson, S., Pearson, J.E. "Saltatory propagation of Ca2+ waves by Ca2+ sparks" . Biophysical Journal, vol. 75, no. 2, 1998, pp. 595-600.http://dx.doi.org/10.1016/S0006-3495(98)77550-2
---------- VANCOUVER ----------
Keizer, J., Smith, G.D., Ponce-Dawson, S., Pearson, J.E. Saltatory propagation of Ca2+ waves by Ca2+ sparks. Biophys. J. 1998;75(2):595-600.http://dx.doi.org/10.1016/S0006-3495(98)77550-2
