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Abstract:

Transforming growth factor β1 (TGFβ1) had no mitogenic effect in Swiss 3T3 cells, but could increase prostaglandin F2α (PGF2α)-induced DNA synthesis. Insulin, but not prostaglandin E1 (PGE1), further enhanced PGF2α action at low TGFβ1 concentrations. TGFβ1 also acted concertedly with the protein kinase C (PKC) activator 1-oleoyl-2-acetylglycerol to induce mitogenesis. Thus, it appears that TGFβ1 and insulin act via separate signals, while TGFβ1 and PGE1 might share a common pathway not involving TGFβ1-mediated prostaglandin synthesis. These results suggest that TGFβ1 might elicit various signalling mechanisms to enhance PGF2α-triggered events. © 1994.

Registro:

Documento: Artículo
Título:Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events
Autor:de Alzaga, M.G.; Goin, M.; Ortiz, M.; de Asua, L.J.
Filiación:Instituto de Investigaciones en Ingenieria Genética y Biología Molecular (INGEBI), Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:DNA synthesis; Insulin; Protein kinase C; TGFβ1; glycerol 2 acetate 1 oleate; insulin; prostaglandin e1; prostaglandin f2 alpha; protein kinase c; transforming growth factor beta1; animal cell; article; controlled study; dna synthesis; mitogenesis; mouse; nonhuman; priority journal; signal transduction; 3T3 Cells; Alprostadil; Animal; Cell Division; Dinoprost; DNA; Insulin; Mice; Mitogens; Signal Transduction; Support, Non-U.S. Gov't; Transforming Growth Factor beta
Año:1994
Volumen:356
Número:1
Página de inicio:21
Página de fin:24
DOI: http://dx.doi.org/10.1016/0014-5793(94)01223-7
Título revista:FEBS Letters
Título revista abreviado:FEBS Lett.
ISSN:00145793
CODEN:FEBLA
CAS:glycerol 2 acetate 1 oleate, 84746-00-9; insulin, 9004-10-8; prostaglandin E1, 745-65-3; prostaglandin F2 alpha, 551-11-1; protein kinase C, 141436-78-4; Alprostadil, 745-65-3; Dinoprost, 551-11-1; DNA, 9007-49-2; Insulin, 11061-68-0; Mitogens; Transforming Growth Factor beta
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v356_n1_p21_deAlzaga

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Citas:

---------- APA ----------
de Alzaga, M.G., Goin, M., Ortiz, M. & de Asua, L.J. (1994) . Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events. FEBS Letters, 356(1), 21-24.
http://dx.doi.org/10.1016/0014-5793(94)01223-7
---------- CHICAGO ----------
de Alzaga, M.G., Goin, M., Ortiz, M., de Asua, L.J. "Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events" . FEBS Letters 356, no. 1 (1994) : 21-24.
http://dx.doi.org/10.1016/0014-5793(94)01223-7
---------- MLA ----------
de Alzaga, M.G., Goin, M., Ortiz, M., de Asua, L.J. "Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events" . FEBS Letters, vol. 356, no. 1, 1994, pp. 21-24.
http://dx.doi.org/10.1016/0014-5793(94)01223-7
---------- VANCOUVER ----------
de Alzaga, M.G., Goin, M., Ortiz, M., de Asua, L.J. Transforming growth factor β1, insulin and prostaglandin E1 enhance prostaglandin F2α mitogenic action in Swiss 3T3 cells via separate events. FEBS Lett. 1994;356(1):21-24.
http://dx.doi.org/10.1016/0014-5793(94)01223-7