Abstract:
1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.
Registro:
Documento: |
Artículo
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Título: | Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I |
Autor: | Rios de Molina del, M.C.; Wainstok de Calmanovici, R.; San Martin de Viale, L.C. |
Filiación: | Laboratorio de Porfirias Experimentales y Metabolismo del Hemo, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez, 1428, Buenos Aires, Argentina Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Nuñez, 1428, Buenos Aires, Argentina
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Palabras clave: | hexachlorobenzene; uroporphyrinogen decarboxylase; animal model; liver; nonhuman; porphyria; rat; Animal; Carboxy-Lyases; Chlorobenzenes; Female; Hexachlorobenzene; Liver; Porphyria; Porphyrinogens; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Uroporphyrinogen Decarboxylase; Uroporphyrinogens |
Año: | 1987
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Volumen: | 19
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Número: | 4
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Página de inicio: | 365
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Página de fin: | 372
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DOI: |
http://dx.doi.org/10.1016/0020-711X(87)90010-3 |
Título revista: | International Journal of Biochemistry
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Título revista abreviado: | Int. J. Biochem.
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ISSN: | 0020711X
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CODEN: | IJBOB
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CAS: | hexachlorobenzene, 118-74-1, 55600-34-5; uroporphyrinogen decarboxylase, 9024-70-8; Carboxy-Lyases, EC 4.1.1.; Chlorobenzenes; Hexachlorobenzene, 118-74-1; Porphyrinogens; Uroporphyrinogen Decarboxylase, EC 4.1.1.37; Uroporphyrinogens
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PDF: | https://bibliotecadigital.exactas.uba.ar/download/paper/paper_0020711X_v19_n4_p365_RiosdeMolinadel.pdf |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v19_n4_p365_RiosdeMolinadel |
Referencias:
- Aragones, Garcia, San Martin de Viale, Tomio, Grinstein, Estudios de la transformación de uroporfirinógenos en coproporfirinógenos por decarboxilasas de eritrocitos de pollo e hígado de rata (1972) An. Asoc. quím. argent., 60, pp. 239-248
- Billi, Koss, San Martin de Viale, Screening for the ability of hexachlorobenzene metabolites to decrease rat liver porphyrinogen carboxylyase (1986) Res. Commun. Chem. Path. Pharmac., 51, pp. 325-336
- Cantoni, Dal Fiume, Ruggieri, Decarboxylation of uroporphyrinogen I and III in 2,3,7,8-tetrachlorodibenzo-p-dioxin induced porphyria in mice (1984) Int. J. Biochem., 16, pp. 561-565
- Cornford, Transformation of porphobilinogen into porphyrins by preparations from human erythrocytes (1964) Biochem. J., 91, pp. 64-73
- Elder, Evans, Matlin, The effect of the porphyrinogenic compound hexachlorobenzene on the activity of hepatic uroporphyrinogen decarboxylase in the rat (1976) Clin. Sci. Mol. Med., 51, pp. 71-80
- Elder, Path, Lee, Tovey, Decreased activity of hepatic uroporphyrinogen decarboxylase in sporadic porphyria cutanea tarda (1978) New Engl. J. Med., 299, pp. 274-278
- Garcia, San Martin de Viale, Tomio, Grinstein, Porphyrin biosynthesis—X. Porphyrinogen carboxylyase from avian erthyrocytes. Further properties (1973) Biochim. biophys. Acta, 309, pp. 203-210
- Jackson, Rao, Supphayen, Smith, Intermediates between Uroporphyrinogen-1 and Coproporphyrinogen-1 (1977) Journal of the Chemical Society, Chemical Communications, 20, pp. 696-698
- Jackson, Sancovich, Ferramola, Evans, Games, Matlin, Elder, Smith, Macrocyclic intermediates in the biosynthesis of porphyrins (1976) Philos. Trans. R. Soc. Lond. Ser. B, 273, pp. 191-206
- Kushner, Barbuto, Lee, An inherited enzymatic defect in porphyria cutanea tarda. Decreased uroporphyrinogen decarboxylase activity (1976) J. clin. Invest., 58, pp. 1089-1097
- Lowry, Rosenbrough, Farr, Randall, Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
- Mauzerall, Granick, Porphyrin biosynthesis in erthrocytes—III. Uroporphyrinogen and its decarboxylase (1958) J. biol. Chem., 232, pp. 1141-1162
- Rios de Molina M. del, Wainstok de Calmanovici, San Martin de Viale, Investigations on the presence of porphyrinogen carboxylase inhibitor in the liver of rats intoxicated with hexachlorobenzene (1980) Int. J. Biochem., 12, pp. 1027-1032
- Rios de Molina M. del, Wainstok de Calmanovici, Tomio, San Martin de Viale, Porfiria inducida en ratas por hexaclorobenceno (1975) An. Asoc. quím. argent., 63, pp. 313-332
- Romeo, Levin, Uroporphyrinogen decarboxylase from mouse spleen (1971) Biochim. biophys. Acta, 230, pp. 330-341
- San Martin de Viale, Rios de Molina M. del, Wainstok de Calmanovici, Tomio, Experimental porphyria induced in rats by hexachlorobenzene. Porphyrins in human diseases (1975) 1st International Porphyrin Meeting on Porphyrins in Human Diseases, pp. 225-232. , M. Doss, Kargel, Basel
- San Martin de Viale, Rios de Molina M. del, Wainstok de Calmanovici, Tomio, Porphyrins and porphyrinogen carboxylyase in hexachlorobenzene-induced porphyria (1977) Biochem. J., 168, pp. 393-400
- San Martin de Viale, Viale, Nacht, Grinstein, Experimental porphyria induced in rats by hexachlorobenzene. A study of the porphyrins excretred by urine (1970) Clin. chim. Acta, 28, pp. 13-23
- Smith, Francis, Investigations of rat liver uroporphyrinogen decarboxylase. Comparisons of porphyrinogens I and III as substrates and the inhibition by porphyrins (1981) Biochem. J., 195, pp. 241-250
- Straka, Kushner, Purification and characterization of bovine hepatic uroporphyrinogen decarboxylase (1983) Biochemistry, 22, pp. 4664-4672
- Tomio, Garcia, San Martin de Viale, Grinstein, Porphyrin biosynthesis. Porphyrinogen carboxylyase from avian erythrocytes. Purification and properties (1970) Biochim. biophys. Acta, 198, pp. 353-363
- Verneuil de, Aitken, Normann, Familial and sporadic porphyria cutanea (1978) Hum. Genet., 44, pp. 145-151
- Verneuil de, Grandchamp, Normann, Some kinetic properties of human red cell uroporphyrinogen decarboxylase (1980) Biochim. biophys. Acta, 611, pp. 174-186
- Verneuil de, Sassa, Kappas, Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III (1983) J. biol. Chem., 258, pp. 2454-2460
- Wainstok de Calmanovici, Rios de Molina M. del, Taira de Yamasato, Tomio, San Martin de Viale, Mechanism of hexachlorobenzene-induced porphyria in rats. Effect of phenobarbitone pretreatment (1984) Biochem. J., 218, pp. 753-763
Citas:
---------- APA ----------
Rios de Molina del, M.C., Wainstok de Calmanovici, R. & San Martin de Viale, L.C.
(1987)
. Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I. International Journal of Biochemistry, 19(4), 365-372.
http://dx.doi.org/10.1016/0020-711X(87)90010-3---------- CHICAGO ----------
Rios de Molina del, M.C., Wainstok de Calmanovici, R., San Martin de Viale, L.C.
"Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I"
. International Journal of Biochemistry 19, no. 4
(1987) : 365-372.
http://dx.doi.org/10.1016/0020-711X(87)90010-3---------- MLA ----------
Rios de Molina del, M.C., Wainstok de Calmanovici, R., San Martin de Viale, L.C.
"Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I"
. International Journal of Biochemistry, vol. 19, no. 4, 1987, pp. 365-372.
http://dx.doi.org/10.1016/0020-711X(87)90010-3---------- VANCOUVER ----------
Rios de Molina del, M.C., Wainstok de Calmanovici, R., San Martin de Viale, L.C. Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I. Int. J. Biochem. 1987;19(4):365-372.
http://dx.doi.org/10.1016/0020-711X(87)90010-3