Artículo

Giacomini, D.; Acuña, M.; Gerez, J.; Nagashima, A.C.; Silberstein, S.; Páez-Pereda, M.; Labeur, M.; Theodoropoulou, M.; Renner, U.; Stalla, G.K.; Arzt, E. "Pituitary action of cytokines: Focus on BMP-4 and gp130 family" (2007) Neuroendocrinology. 85(2):94-100
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Abstract:

The anterior pituitary can develop benign tumors of different sizes, classified as micro- and macroadenomas, frequently associated with high levels of hormone production, leading to different associated syndromes like Cushing's disease, acromegaly or prolactinomas. Much work has been done in order to understand the signaling pathways and the factors and hormones involved in the pituitary tumorigenic process. In recent years, much evidence has been collected and it is now well documented that cytokines of the gp130 family, such as interleukin-6, that use gp130 as a common signaling protein stimulate not only the proliferation but also the hormone secretion of pituitary cells. Experiments in vivo have shown that the overexpression of the gp130 receptor resulted in pituitary abnormal growth. Moreover, it has been recently described that bone morphogenetic protein-4 (BMP-4), a member of the TGF-β family, has a stimulatory role on lactosomatotropic cells promoting the development of prolactinomas but it has an inhibitory action on the corticotropic lineage. This inhibitory action prevents Cushing's disease progression. Furthermore, BMP-4 mediates the antiproliferative action of retinoic acid in these cells. The present review highlights the most recent work about gp130 and TGF-β cytokine families and their role in pituitary tumorigenesis. Copyright © 2007 S. Karger AG.

Registro:

Documento: Artículo
Título:Pituitary action of cytokines: Focus on BMP-4 and gp130 family
Autor:Giacomini, D.; Acuña, M.; Gerez, J.; Nagashima, A.C.; Silberstein, S.; Páez-Pereda, M.; Labeur, M.; Theodoropoulou, M.; Renner, U.; Stalla, G.K.; Arzt, E.
Filiación:Laboratorio de Fisiología Y Biología Molecular, Departamento de Fisiología Y Biología Molecular Y Celular, Universidad de Buenos Aires, Buenos Aires, Argentina
Max Planck Institute of Psychiatry, Munich, Germany
Affectis Pharmaceuticals, Munich, Germany
Laboratorio de Fisiología Y Biología Molecular, Departamento de Fisiología Y Biología Molecular Y Celular, Pabellón II, C1428EHA, Buenos Aires, Argentina
IFYBINE-Argentine National Research Council (CONICET), Argentina
Palabras clave:gp130 family; Pituitary action of cytokines; TGF-β family; bone morphogenetic protein 4; cytokine; glycoprotein gp 130; interleukin 6; retinoic acid; acromegaly; adenohypophysis; adenohypophysis disease; benign tumor; carcinogenesis; cell proliferation; conference paper; Cushing disease; disease association; disease course; gene overexpression; hormone release; hormone synthesis; human; hypophysis cell; hypophysis tumor; in vivo study; microadenoma; nonhuman; priority journal; prolactinoma; protein family; signal transduction; tumor classification; tumor volume; Animals; Bone Morphogenetic Proteins; Cytokine Receptor gp130; Cytokines; Humans; Models, Biological; Multigene Family; Pituitary Gland
Año:2007
Volumen:85
Número:2
Página de inicio:94
Página de fin:100
DOI: http://dx.doi.org/10.1159/000100428
Título revista:Neuroendocrinology
Título revista abreviado:Neuroendocrinology
ISSN:00283835
CODEN:NUNDA
CAS:retinoic acid, 302-79-4; Bone Morphogenetic Proteins; Cytokine Receptor gp130, 133483-10-0; Cytokines; bone morphogenetic protein 4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v85_n2_p94_Giacomini

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Citas:

---------- APA ----------
Giacomini, D., Acuña, M., Gerez, J., Nagashima, A.C., Silberstein, S., Páez-Pereda, M., Labeur, M.,..., Arzt, E. (2007) . Pituitary action of cytokines: Focus on BMP-4 and gp130 family. Neuroendocrinology, 85(2), 94-100.
http://dx.doi.org/10.1159/000100428
---------- CHICAGO ----------
Giacomini, D., Acuña, M., Gerez, J., Nagashima, A.C., Silberstein, S., Páez-Pereda, M., et al. "Pituitary action of cytokines: Focus on BMP-4 and gp130 family" . Neuroendocrinology 85, no. 2 (2007) : 94-100.
http://dx.doi.org/10.1159/000100428
---------- MLA ----------
Giacomini, D., Acuña, M., Gerez, J., Nagashima, A.C., Silberstein, S., Páez-Pereda, M., et al. "Pituitary action of cytokines: Focus on BMP-4 and gp130 family" . Neuroendocrinology, vol. 85, no. 2, 2007, pp. 94-100.
http://dx.doi.org/10.1159/000100428
---------- VANCOUVER ----------
Giacomini, D., Acuña, M., Gerez, J., Nagashima, A.C., Silberstein, S., Páez-Pereda, M., et al. Pituitary action of cytokines: Focus on BMP-4 and gp130 family. Neuroendocrinology. 2007;85(2):94-100.
http://dx.doi.org/10.1159/000100428