Artículo
Abstract:
The spontaneous isometric developed tension (IDT) and the frequency of contractions (FC) of the implantation or linea uteri (LU) and the non implantation or myometrial region (M) from uterine horns in different stages of the sex cycle were studied. The functional activity (FA= IDT × FC) of LU and M decreased with time comparably in proestrus and metestrus whereas during estrus the stability was significantly higher in the implantation region than in M. In uterine strips isolated from proestrus animals indomethacin (2; 5 or 10 μg/ml) did not change the functional activity neither of LU nor of M; on the contrary in metestrus, indomethacin diminished significantly the functional activity of both uterine regions. When the uterine strips (M and LU) were obtained from animals in estrus, only the implantation region was depressed by indomethacin at the 3 concentrations tested. The release of PGE and PGF-like material by incubated strips of M and LU obtained from estrus rats was also studied. The PGE-like material generated by the implantation zone was significantly higher than that released by non implantation region. Regarding PGF-like material, the spontaneous release was similar in M and LU. On the other hand PGI2-like material generated by LU and M was not significantly different. The probable implications of the differences found in these two regions of the estrus uterus are discussed. © 1981 The Italian Pharmacological Society.
Registro:
| Documento: | Artículo |
| Título: | The spontaneous motility and the prostaglandin E-like material generation is different in the implantation and in the non-implantation regions of the uterus isolated from rats in natural estrus. Influences of indomethacin |
| Autor: | Gimeno, A.L.; Borda, E.S.; Peredo, H.A.; Franchi, A.M.; Lazzari, M.A.; Gimeno, M.F. |
| Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnica e la Republica Argentina (CONICET), Instituto de Investigaciones Hematológicas, 1428 Buenos Aires, Argentina |
| Palabras clave: | indometacin; prostacyclin; prostaglandin; prostaglandin e2; prostaglandin f2 alpha; animal experiment; endocrine system; estrus; female genital system; in vitro study; nidation; rat; uterus contractility; Animals; Dinoprost; Dinoprostone; Embryo Implantation; Epoprostenol; Estrus; Female; Indomethacin; Myometrium; Pregnancy; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Uterine Contraction; Uterus |
| Año: | 1981 |
| Volumen: | 13 |
| Número: | 7 |
| Página de inicio: | 679 |
| Página de fin: | 694 |
| DOI: | http://dx.doi.org/10.1016/S0031-6989(81)80056-2 |
| Título revista: | Pharmacological Research Communications |
| Título revista abreviado: | Pharmacol. Res. Commun. |
| ISSN: | 00316989 |
| CODEN: | PLRCA |
| CAS: | indometacin, 53-86-1, 74252-25-8, 7681-54-1; prostacyclin, 35121-78-9, 61849-14-7; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Epoprostenol, 35121-78-9; Indomethacin, 53-86-1; Prostaglandins E; Prostaglandins F |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n7_p679_Gimeno |
Referencias:
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Citas:
---------- APA ----------
Gimeno, A.L., Borda, E.S., Peredo, H.A., Franchi, A.M., Lazzari, M.A. & Gimeno, M.F. (1981) . The spontaneous motility and the prostaglandin E-like material generation is different in the implantation and in the non-implantation regions of the uterus isolated from rats in natural estrus. Influences of indomethacin. Pharmacological Research Communications, 13(7), 679-694.http://dx.doi.org/10.1016/S0031-6989(81)80056-2
---------- CHICAGO ----------
Gimeno, A.L., Borda, E.S., Peredo, H.A., Franchi, A.M., Lazzari, M.A., Gimeno, M.F. "The spontaneous motility and the prostaglandin E-like material generation is different in the implantation and in the non-implantation regions of the uterus isolated from rats in natural estrus. Influences of indomethacin" . Pharmacological Research Communications 13, no. 7 (1981) : 679-694.http://dx.doi.org/10.1016/S0031-6989(81)80056-2
---------- MLA ----------
Gimeno, A.L., Borda, E.S., Peredo, H.A., Franchi, A.M., Lazzari, M.A., Gimeno, M.F. "The spontaneous motility and the prostaglandin E-like material generation is different in the implantation and in the non-implantation regions of the uterus isolated from rats in natural estrus. Influences of indomethacin" . Pharmacological Research Communications, vol. 13, no. 7, 1981, pp. 679-694.http://dx.doi.org/10.1016/S0031-6989(81)80056-2
---------- VANCOUVER ----------
Gimeno, A.L., Borda, E.S., Peredo, H.A., Franchi, A.M., Lazzari, M.A., Gimeno, M.F. The spontaneous motility and the prostaglandin E-like material generation is different in the implantation and in the non-implantation regions of the uterus isolated from rats in natural estrus. Influences of indomethacin. Pharmacol. Res. Commun. 1981;13(7):679-694.http://dx.doi.org/10.1016/S0031-6989(81)80056-2
