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Abstract:

Among the wide variety of pharmaceuticals released into the environment, Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is one of the most prescribed for the treatment of major depression. It inhibits serotonin (5-HT) reuptake at the presinaptic membrane, increasing serotonergic activity. In vertebrates, including fish, the serotonergic system is closely related to the Hypothalamic Pituitary Gonadal (HPG) axis which regulates reproduction. As FLX can act as an endocrine disrupting compound (EDC) by affecting several reproductive parameters in fish, the aim of this study was to provide an integral assessment of the potential effect of FLX on the reproductive axis of the Neotropical freshwater fish Cichlasoma dimerus. Adult fish were intraperitoneally injected with 2 μg g−1FLX or saline every third day for 15 days. No significant differences were found on serotonergic turnover (5-HIAA/5-HT ratio). Pituitary βLH content in FLX injected females was significantly higher than control females; no significant differences were seen for βFSH content. Sex steroids remained unaltered, both in males and females fish, after FLX treatment. No plasma vitellogenin was induced in treated males. Some alterations were seen in testes of FLX injected males, such as the presence of foam cells and an acidophilic PAS positive, Alcian-Blue negative secretion in the lobular lumen. Although there is no clear consensus about the effect of this drug on reproductive physiology, these results indicate that FLX is acting as a mild EDC in adults of C. dimerus. © 2016 Elsevier Ltd

Registro:

Documento: Artículo
Título:The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)
Autor:Dorelle, L.S.; Da Cuña, R.H.; Rey Vázquez, G.; Höcht, C.; Shimizu, A.; Genovese, G.; Lo Nostro, F.L.
Filiación:Laboratorio de Ecotoxicología Acuática, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires & Instituto de Biodiversidad y Biología Experimental y Aplicada IBBEA, CONICET-UBA, Buenos Aires, C1428EGA, Argentina
Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos (UBA), Buenos Aires, C1113AAD, Argentina
National Research Institute of Fisheries Science, Fisheries Research Agency, Kanazawa, Yokohama, 236-8648, Japan
Palabras clave:Contaminants of emerging concern; Endocrine disruption; Gonadotrophins; Pharmaceuticals; Reproduction; Serotonin; Controlled drug delivery; Drug products; Fish; Physiology; Contaminants of emerging concerns; Endocrine disruption; Gonadotrophins; Reproduction; Serotonin; Endocrine disrupters; alcian blue; estradiol; fluoxetine; follitropin beta subunit; luteinizing hormone beta subunit; sodium chloride; testosterone; vitellogenin; endocrine disruptor; fluoxetine; serotonin uptake inhibitor; steroid; water pollutant; chemical compound; cichlid; drug; endocrine disruptor; hormone; inhibitor; physiology; pollutant; protein; reproduction; steroid; adult; animal experiment; animal tissue; Article; Cichlasoma dimerus; cichlid; controlled study; estradiol blood level; female; foam cell; follitropin blood level; hypophysis; luteinizing hormone blood level; male; Neotropics; nonhuman; ovary tissue; reproduction; reproductive toxicity; serotoninergic system; testosterone blood level; animal; cichlid; drug effects; ecotoxicology; metabolism; physiology; reproduction; toxicity; water pollutant; Cichlasoma; Cichlidae; Teleostei; Vertebrata; Animals; Cichlids; Ecotoxicology; Endocrine Disruptors; Female; Fluoxetine; Male; Pituitary Gland; Reproduction; Serotonin Uptake Inhibitors; Steroids; Water Pollutants, Chemical
Año:2017
Volumen:171
Página de inicio:370
Página de fin:378
DOI: http://dx.doi.org/10.1016/j.chemosphere.2016.11.141
Título revista:Chemosphere
Título revista abreviado:Chemosphere
ISSN:00456535
CODEN:CMSHA
CAS:alcian blue, 12040-44-7; estradiol, 50-28-2; fluoxetine, 54910-89-3, 56296-78-7, 59333-67-4; sodium chloride, 7647-14-5; testosterone, 58-22-0; Endocrine Disruptors; Fluoxetine; Serotonin Uptake Inhibitors; Steroids; Water Pollutants, Chemical
Registro:http://digital.bl.fcen.uba.ar/collection/paper/document/paper_00456535_v171_n_p370_Dorelle

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Citas:

---------- APA ----------
Dorelle, L.S., Da Cuña, R.H., Rey Vázquez, G., Höcht, C., Shimizu, A., Genovese, G. & Lo Nostro, F.L. (2017) . The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes). Chemosphere, 171, 370-378.
http://dx.doi.org/10.1016/j.chemosphere.2016.11.141
---------- CHICAGO ----------
Dorelle, L.S., Da Cuña, R.H., Rey Vázquez, G., Höcht, C., Shimizu, A., Genovese, G., et al. "The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)" . Chemosphere 171 (2017) : 370-378.
http://dx.doi.org/10.1016/j.chemosphere.2016.11.141
---------- MLA ----------
Dorelle, L.S., Da Cuña, R.H., Rey Vázquez, G., Höcht, C., Shimizu, A., Genovese, G., et al. "The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)" . Chemosphere, vol. 171, 2017, pp. 370-378.
http://dx.doi.org/10.1016/j.chemosphere.2016.11.141
---------- VANCOUVER ----------
Dorelle, L.S., Da Cuña, R.H., Rey Vázquez, G., Höcht, C., Shimizu, A., Genovese, G., et al. The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes). Chemosphere. 2017;171:370-378.
http://dx.doi.org/10.1016/j.chemosphere.2016.11.141