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Abstract:

We report a case of partial deficiency of α2-antiplasmin. A 45 year old Spanish man had a life long severe bleeding tendency after trauma. Routine coagulation and platelet functional tests in symptomatic and asymptomatic periods were normal. During the bleeding there was a rapid whole blood clot lysis and the concentration of α2-antiplasmin in plasma was 20 to 25 % of normal controls. After recovery these levels showed a slight increase (35 to 45 % of normal). Addition of normal plasma to the patient's plasma increased α2-plasmin inhibitor activity. Bidimensional electrophoresis of α2-antiplasmin in the patient's plasma showed a normal pattern. Family studies showed that one of the proband'R two sons had a mild hemorrhagic tendency and 140 % of functional and antigenic levels of α2-antiplasmin. © 1985.

Registro:

Documento: Artículo
Título:Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency
Autor:Kordich, L.; Feldman, L.; Porterie, P.; Lago, O.
Filiación:Hospital Privado Güemes, Buenos Aires, Argentina
Facultad de Ciencias Exactas, Naturales. Universidad de Buenos Aires, Argentina
Hospital Ramon Sanmartina. Universidad Nacional, Centro de la Provincia de Buenos Aires, Tandil, Argentina
Palabras clave:Hemorrhagic tendency; Heterozygous; α2-Antiplasmin deficiency; alpha 2 antiplasmin; bleeding disorder; blood and hemopoietic system; case report; enzyme deficiency; fibrinolysis; human; priority journal; Antiplasmin; Blood Coagulation Factors; Blood Coagulation Tests; Case Report; Fibrinolysis; Hemorrhage; Heterozygote; Human; Male; Middle Age; Platelet Count; Platelet Function Tests; Reference Values
Año:1985
Volumen:40
Número:5
Página de inicio:645
Página de fin:651
DOI: http://dx.doi.org/10.1016/0049-3848(85)90302-0
Título revista:Thrombosis Research
Título revista abreviado:Thromb. Res.
ISSN:00493848
CODEN:THBRA
CAS:Antiplasmin; Blood Coagulation Factors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v40_n5_p645_Kordich

Referencias:

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Citas:

---------- APA ----------
Kordich, L., Feldman, L., Porterie, P. & Lago, O. (1985) . Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency. Thrombosis Research, 40(5), 645-651.
http://dx.doi.org/10.1016/0049-3848(85)90302-0
---------- CHICAGO ----------
Kordich, L., Feldman, L., Porterie, P., Lago, O. "Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency" . Thrombosis Research 40, no. 5 (1985) : 645-651.
http://dx.doi.org/10.1016/0049-3848(85)90302-0
---------- MLA ----------
Kordich, L., Feldman, L., Porterie, P., Lago, O. "Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency" . Thrombosis Research, vol. 40, no. 5, 1985, pp. 645-651.
http://dx.doi.org/10.1016/0049-3848(85)90302-0
---------- VANCOUVER ----------
Kordich, L., Feldman, L., Porterie, P., Lago, O. Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency. Thromb. Res. 1985;40(5):645-651.
http://dx.doi.org/10.1016/0049-3848(85)90302-0