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Abstract:

The effect of corticosterone (CC, 0.4 and 1 μg/ml) and of hydrocortisone (HC, 20 and 40 μg/ml) on the spontaneous motility and on prostaglandin (PG) generation in the uterus from ovariectomized rats, was studied. Both concentrations of CC depressed significantly the frequency of contractions but the isometric developed tension was affected only by the higher dose. HC concentrations whereas the contractile frequency was only depressed by the higher one. The CC-inhibited motility was accompanied by a reduction in the amount of PGs released from the uterus into the bath solution. In addition, the influence of arachidonic acid (AA), linoleic acid (LA) and gamma-linolenic acid (γ-LA) - 1 or 2 μg/ml - on the depression evoked by CC, were also explored. The fatty acids had no effect on the spontaneous uterine motility except in the case of γ-LA at 1 μg/ml. γ-LA completely blocked the CC-evoked reduction of bothe tension and frequency; AA (1μg/ml) elicited a reversion only on frequency whereas LA had no effect at all. This reversion by a fatty acid PG-precursor might indicate that CC is able to diminish substrate availability for PG synthesis in the rat uterus. © 1982.

Registro:

Documento: Artículo
Título:Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats
Autor:Bonacossa, A.; Sterin-Speziale, N.; Gimeno, M.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacologicos y de Principios Naturales (CEFAPRIN) CONICET. V. de Obligado 2490., 1428 Buenos Aires, Argentina
Palabras clave:arachidonic acid; corticosterone; gamma linolenic acid; hydrocortisone; linoleic acid; prostaglandin; animal experiment; drug comparison; female genital system; in vitro study; ovariectomy; rat; uterus; uterus contractility; Animal; Arachidonic Acid; Arachidonic Acids; Castration; Corticosterone; Dose-Response Relationship, Drug; Female; gamma-Linolenic Acid; Hydrocortisone; In Vitro; Linoleic Acid; Linoleic Acids; Linolenic Acids; Prostaglandins; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Uterine Contraction; Uterus
Año:1982
Volumen:23
Número:1
Página de inicio:113
Página de fin:128
DOI: http://dx.doi.org/10.1016/0090-6980(82)90027-2
Título revista:Prostaglandins
Título revista abreviado:Prostaglandins
ISSN:00906980
CODEN:PRGLB
CAS:arachidonic acid, 506-32-1, 6610-25-9, 7771-44-0; corticosterone, 50-22-6; gamma linolenic acid, 1686-12-0; hydrocortisone, 50-23-7; linoleic acid, 1509-85-9, 2197-37-7, 60-33-3, 822-17-3; Arachidonic Acid, 506-32-1; Arachidonic Acids; Corticosterone, 50-22-6; gamma-Linolenic Acid, 506-26-3; Hydrocortisone, 50-23-7; Linoleic Acid, 2197-37-7; Linoleic Acids; Linolenic Acids; Prostaglandins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v23_n1_p113_Bonacossa

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Citas:

---------- APA ----------
Bonacossa, A., Sterin-Speziale, N., Gimeno, M.F. & Gimeno, A.L. (1982) . Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. Prostaglandins, 23(1), 113-128.
http://dx.doi.org/10.1016/0090-6980(82)90027-2
---------- CHICAGO ----------
Bonacossa, A., Sterin-Speziale, N., Gimeno, M.F., Gimeno, A.L. "Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats" . Prostaglandins 23, no. 1 (1982) : 113-128.
http://dx.doi.org/10.1016/0090-6980(82)90027-2
---------- MLA ----------
Bonacossa, A., Sterin-Speziale, N., Gimeno, M.F., Gimeno, A.L. "Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats" . Prostaglandins, vol. 23, no. 1, 1982, pp. 113-128.
http://dx.doi.org/10.1016/0090-6980(82)90027-2
---------- VANCOUVER ----------
Bonacossa, A., Sterin-Speziale, N., Gimeno, M.F., Gimeno, A.L. Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. Prostaglandins. 1982;23(1):113-128.
http://dx.doi.org/10.1016/0090-6980(82)90027-2