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Pedreira, M.E.; Dimant, B.; Tomsic, D.; Quesada-Allue, L.A.; Maldonado, H. "Cycloheximide inhibits context memory and long-term habituation in the crab Chasmagnathus" (1995) Pharmacology, Biochemistry and Behavior. 52(2):385-395
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Abstract:

A shadow moving over head elicits an escape response in the crab Chasmagnathus that habituates promptly and for a long period. The effect of the protein synthesis inhibitor Cycloheximide (CY) on this long-term memory was analyzed. Two hours after injection, 10 μg CY inhibited [14C]-amino acid incorporation into cerebral plus thoracic ganglia by 88% and 20 μg by 92%, but no inhibition was found at 24 h. A single injection of 10-20 μg, CY given 30 min before training, failed to affect the short-term habituation. Similar doses impaired both context memory (CM) and long-term habituation (LTH) when tested at 72 and 120 h but only CM at 24 h. Such a disparity was explained by an unspecific depressing effect upon the response, attributed to an interaction between CY and training. The hypothesis was confirmed, because CY injected immediately after training disclosed amnestic effect at 24 h on both CM and LTH. A similar effect was proven when animals were injected at 2 h but not at 6 h after training. Results from experiments with pretraining and pretesting injections put aside a state-dependence or retrieval deficit effects of the drug. Taken together, findings of this article argue strongly for de novo protein synthesis as a mechanism of LTH and for the close relation between CM and LTH. © 1995.

Registro:

Documento: Artículo
Título:Cycloheximide inhibits context memory and long-term habituation in the crab Chasmagnathus
Autor:Pedreira, M.E.; Dimant, B.; Tomsic, D.; Quesada-Allue, L.A.; Maldonado, H.
Filiación:Laboratorio de Fisiología del Comportamiento Animal, Facultad de Ciencias Exactas y Naturales, Depto Biología, Pab 2. Ciudad Universitaria, 1428 Buenos Aires, Argentina
Instituto de Investigations Bioquímicas Fundación Campomar A. Machado, 151 Buenos Aires, Argentina
Palabras clave:Arthropoda; Crab; Cycloheximide; Habituation; Memory; amino acid mixture; cycloheximide; protein synthesis inhibitor; radioisotope; amnesia; animal experiment; animal tissue; article; brain; controlled study; crab; escape behavior; ganglion; habituation; long term memory; male; nonhuman; priority journal; protein synthesis; short term memory; training; Amino Acids; Amnesia; Animal; Brachyura; Conditioning, Operant; Cycloheximide; Escape Reaction; Ganglia, Invertebrate; Habituation (Psychophysiology); Male; Memory; Protein Synthesis Inhibitors; Support, Non-U.S. Gov't; Animalia; Arthropoda; Chasmagnathus; Decapoda (Crustacea)
Año:1995
Volumen:52
Número:2
Página de inicio:385
Página de fin:395
DOI: http://dx.doi.org/10.1016/0091-3057(95)00124-F
Título revista:Pharmacology, Biochemistry and Behavior
Título revista abreviado:Pharmacol. Biochem. Behav.
ISSN:00913057
CODEN:PBBHA
CAS:Amino Acids; Cycloheximide, 66-81-9; Protein Synthesis Inhibitors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v52_n2_p385_Pedreira

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Citas:

---------- APA ----------
Pedreira, M.E., Dimant, B., Tomsic, D., Quesada-Allue, L.A. & Maldonado, H. (1995) . Cycloheximide inhibits context memory and long-term habituation in the crab Chasmagnathus. Pharmacology, Biochemistry and Behavior, 52(2), 385-395.
http://dx.doi.org/10.1016/0091-3057(95)00124-F
---------- CHICAGO ----------
Pedreira, M.E., Dimant, B., Tomsic, D., Quesada-Allue, L.A., Maldonado, H. "Cycloheximide inhibits context memory and long-term habituation in the crab Chasmagnathus" . Pharmacology, Biochemistry and Behavior 52, no. 2 (1995) : 385-395.
http://dx.doi.org/10.1016/0091-3057(95)00124-F
---------- MLA ----------
Pedreira, M.E., Dimant, B., Tomsic, D., Quesada-Allue, L.A., Maldonado, H. "Cycloheximide inhibits context memory and long-term habituation in the crab Chasmagnathus" . Pharmacology, Biochemistry and Behavior, vol. 52, no. 2, 1995, pp. 385-395.
http://dx.doi.org/10.1016/0091-3057(95)00124-F
---------- VANCOUVER ----------
Pedreira, M.E., Dimant, B., Tomsic, D., Quesada-Allue, L.A., Maldonado, H. Cycloheximide inhibits context memory and long-term habituation in the crab Chasmagnathus. Pharmacol. Biochem. Behav. 1995;52(2):385-395.
http://dx.doi.org/10.1016/0091-3057(95)00124-F