Abstract:
Chemoenzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol was achieved by esterification of 1-O-hexadecyl-sn-glycerol, with palmitic acid in the presence of N,N-dicyclohexylcarbodiimide, and then subjected to alcoholysis catalysed by an immobilized 1,3-specific lipase. The highest yield (90% from 0.3 mM) was obtained in 3 h, using methyl isobutyl ketone as solvent with water activity 0.2.
Registro:
Documento: |
Artículo
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Título: | Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol |
Autor: | Salto, M.L.; Bertello, L.E.; De Lederkremer, R.M. |
Filiación: | Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II, 1428 Buenos Aires, Argentina
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Palabras clave: | 4 methyl 2 pentanone; dicyclohexylcarbodiimide; glycerol derivative; palmitic acid; solvent; triacylglycerol lipase; article; enzyme immobilization; esterification; synthesis; time |
Año: | 1997
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Volumen: | 19
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Número: | 9
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Página de inicio: | 853
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Página de fin: | 855
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DOI: |
http://dx.doi.org/10.1023/A:1018377318338 |
Título revista: | Biotechnology Letters
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Título revista abreviado: | BIOTECHNOL. LETT.
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ISSN: | 01415492
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CODEN: | BILED
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01415492_v19_n9_p853_Salto |
Referencias:
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Citas:
---------- APA ----------
Salto, M.L., Bertello, L.E. & De Lederkremer, R.M.
(1997)
. Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol. Biotechnology Letters, 19(9), 853-855.
http://dx.doi.org/10.1023/A:1018377318338---------- CHICAGO ----------
Salto, M.L., Bertello, L.E., De Lederkremer, R.M.
"Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol"
. Biotechnology Letters 19, no. 9
(1997) : 853-855.
http://dx.doi.org/10.1023/A:1018377318338---------- MLA ----------
Salto, M.L., Bertello, L.E., De Lederkremer, R.M.
"Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol"
. Biotechnology Letters, vol. 19, no. 9, 1997, pp. 853-855.
http://dx.doi.org/10.1023/A:1018377318338---------- VANCOUVER ----------
Salto, M.L., Bertello, L.E., De Lederkremer, R.M. Chemo-enzymatic synthesis of 1-O-hexadecyl-2-O-palmitoyl-sn-glycerol. BIOTECHNOL. LETT. 1997;19(9):853-855.
http://dx.doi.org/10.1023/A:1018377318338