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Abstract:

Two heparan sulphates, of different N- and O-sulphate content and iduronic/ glucuronic acid ratio (HS I and HS II), were submitted to partial periodate oxidation, borohydride reduction and subsequent O-sulphation. The sulphated derivatives showed increased anticoagulant activities by APTT assay and were significantly degraded by heparinase. © 1997 Published by Elsevier Science Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction
Autor:Kovensky, J.; Fernández Cirelli, A.
Filiación:Depto. de Quim. Orgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428, Buenos Aires, Argentina
Palabras clave:Assays; Carboxylic acids; Chemical modification; Composition effects; Degradation; Derivatives; Oxidation; Reduction; Borohydride reduction; Glycosaminoglycans; Heparan sulfates; Heparinase; Iduronic/glucoronic acid ratio; Periodate oxidation; Sulphation; Polysaccharides
Año:1996
Volumen:31
Número:4
Página de inicio:211
Página de fin:214
DOI: http://dx.doi.org/10.1016/S0144-8617(96)00125-7
Título revista:Carbohydrate Polymers
Título revista abreviado:Carbohydr Polym
ISSN:01448617
CODEN:CAPOD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v31_n4_p211_Kovensky

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Citas:

---------- APA ----------
Kovensky, J. & Fernández Cirelli, A. (1996) . Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction. Carbohydrate Polymers, 31(4), 211-214.
http://dx.doi.org/10.1016/S0144-8617(96)00125-7
---------- CHICAGO ----------
Kovensky, J., Fernández Cirelli, A. "Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction" . Carbohydrate Polymers 31, no. 4 (1996) : 211-214.
http://dx.doi.org/10.1016/S0144-8617(96)00125-7
---------- MLA ----------
Kovensky, J., Fernández Cirelli, A. "Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction" . Carbohydrate Polymers, vol. 31, no. 4, 1996, pp. 211-214.
http://dx.doi.org/10.1016/S0144-8617(96)00125-7
---------- VANCOUVER ----------
Kovensky, J., Fernández Cirelli, A. Chemical modification of glycosaminoglycans. Sulphation of heparan sulphate derivatives obtained by periodate oxidation/borohydride reduction. Carbohydr Polym. 1996;31(4):211-214.
http://dx.doi.org/10.1016/S0144-8617(96)00125-7