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Fernández, L.R.; Butassi, E.; Svetaz, L.; Zacchino, S.A.; Palermo, J.A.; Sánchez, M. "Antifungal terpenoids from Hyalis argentea var. latisquama" (2014) Journal of Natural Products. 77(7):1579-1585
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Abstract:

A detailed chemical study of the aerial parts and rhizomes of Hyalis argentea var. latisquama yielded a variety of sesqui- and diterpenes. In total, 26 compounds were isolated and identified, of which four are new, namely, two ent-kaurenes (1 and 2), a diterpene lactone (3), and a lindenanolide (4). The previously reported compounds included a series of lindenanolides, guaianolides, elemanolides, and additional diterpenes. The antifungal activity of the isolated compounds was tested against Cryptococcus neoformans and Candida albicans. Among the isolated compounds, the lindenanolides were the only structural class that showed strong antifungal activity, and onoseriolide acetate (5) was the most active. On the other hand, the isolated guaianolides were only moderately active, while the diterpenes did not show significant antifungal activity. © 2014 The American Chemical Society and American Society of Pharmacognosy.

Registro:

Documento: Artículo
Título:Antifungal terpenoids from Hyalis argentea var. latisquama
Autor:Fernández, L.R.; Butassi, E.; Svetaz, L.; Zacchino, S.A.; Palermo, J.A.; Sánchez, M.
Filiación:UMYMFOR, Departamento de Química Orgánica, Universidad de Buenos Aires, CP1428, Buenos Aires, Argentina
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, CP2000, Rosario, Argentina
Palabras clave:8alpha,9alpha exposyonoseriolide acetate; amphotericin B; ent 7alpha hydroxy 15 oxokauran 19 beta dextro glucopyranosyl ester; ent 7alpha,15beta dihydroxykaur 16 ene 19 beta dextro glucopyranosyl ester; hyalic acid beta dextro glucopyranosyl ester; terpenoid derivative; unclassified drug; antifungal activity; article; Candida albicans; controlled study; Cryptococcus neoformans; drug identification; drug isolation; fungus growth; growth inhibition; Hyalis latisquama; medicinal plant; nonhuman; rhizome; Antifungal Agents; Asteraceae; Candida albicans; Cryptococcus neoformans; Diterpenes, Kaurane; Molecular Structure; Sesquiterpenes; Sesquiterpenes, Guaiane
Año:2014
Volumen:77
Número:7
Página de inicio:1579
Página de fin:1585
DOI: http://dx.doi.org/10.1021/np500032u
Título revista:Journal of Natural Products
Título revista abreviado:J. Nat. Prod.
ISSN:01633864
CODEN:JNPRD
CAS:amphotericin B, 1397-89-3, 30652-87-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v77_n7_p1579_Fernandez

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Citas:

---------- APA ----------
Fernández, L.R., Butassi, E., Svetaz, L., Zacchino, S.A., Palermo, J.A. & Sánchez, M. (2014) . Antifungal terpenoids from Hyalis argentea var. latisquama. Journal of Natural Products, 77(7), 1579-1585.
http://dx.doi.org/10.1021/np500032u
---------- CHICAGO ----------
Fernández, L.R., Butassi, E., Svetaz, L., Zacchino, S.A., Palermo, J.A., Sánchez, M. "Antifungal terpenoids from Hyalis argentea var. latisquama" . Journal of Natural Products 77, no. 7 (2014) : 1579-1585.
http://dx.doi.org/10.1021/np500032u
---------- MLA ----------
Fernández, L.R., Butassi, E., Svetaz, L., Zacchino, S.A., Palermo, J.A., Sánchez, M. "Antifungal terpenoids from Hyalis argentea var. latisquama" . Journal of Natural Products, vol. 77, no. 7, 2014, pp. 1579-1585.
http://dx.doi.org/10.1021/np500032u
---------- VANCOUVER ----------
Fernández, L.R., Butassi, E., Svetaz, L., Zacchino, S.A., Palermo, J.A., Sánchez, M. Antifungal terpenoids from Hyalis argentea var. latisquama. J. Nat. Prod. 2014;77(7):1579-1585.
http://dx.doi.org/10.1021/np500032u