Artículo
Abstract:
The effects of progesterone in the solution suspending uterine preparations isolated from ovariectomized rats on the output of PGF2α and PGE2-like material, were explored. Uterine incubation for one hour with progesterone (50 or 100 ug/ml, final concentration) did not alter PGF or PGE release into the bath medium, when compared with untreated controls. One hour after hormone removal the output of either prostaglandin, from uteri previously primed with progesterone at 50 ug/ml, was also similar to controls. However, preparations exposed to progesterone at 100 ug/ml for one hour and subjected afterwards to a second incubation of interval of 60 minutes without the hormone, released into the suspending medium significantly more PGF, but not PGE, than controls. On the other hand, incubation with progesterone (at 100 ug/ml) for 120 minutes (not followed by a period of steroid removal) failed to change PGF and PGE uterine output. These findings show that there is a direct but complex effect of progesterone on rat uterine release of PGF, i.e., the positive correlation between the steroid and PGF required not only a priming period with a high concentration of progesterone but also its subsequent withdrawal. Such peculiarity is discussed in terms of a possible influence of progesterone on enhancing intramural uterine levels of PGF and inhibiting prostaglandin release, and also in relation to the role of hormone withdrawal after corpora lutea regression on PGF concentration in blood from uterine veins during the sex cycle. © 1984.
Registro:
| Documento: | Artículo |
| Título: | Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal? |
| Autor: | Gimeno, A.L.; Franchi, A.M.; González, E.T.; Gimeno, M.F. |
| Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo National de Investigaciones Cientificas y Tecnicas de le Republica Argentina (CONICET). Serr, 1414 Buenos Aires, Argentina |
| Palabras clave: | progesterone; prostaglandin e; prostaglandin e2; prostaglandin f2 alpha; animal cell; drug mechanism; endocrine system; female genital system; nonhuman; ovariectomy; rat; uterus; Animal; Castration; Dinoprost; Dinoprostone; Female; In Vitro; Progesterone; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Uterus |
| Año: | 1984 |
| Volumen: | 14 |
| Número: | 2 |
| Página de inicio: | 289 |
| Página de fin: | 296 |
| DOI: | http://dx.doi.org/10.1016/0262-1746(84)90213-0 |
| Título revista: | Prostaglandins, Leukotrienes and Medicine |
| Título revista abreviado: | Prostaglandins Leukotrienes Med. |
| ISSN: | 02621746 |
| CODEN: | PLMED |
| CAS: | progesterone, 57-83-0; prostaglandin E, 11042-70-9; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Progesterone, 57-83-0; Prostaglandins E; Prostaglandins F |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v14_n2_p289_Gimeno |
Referencias:
- Franchi, Bonecossa, Gimeno, Gimeno, Effect of progesterone on the spontaneous motility and prostaglandin synthesis in uterine horns isolated from ovariectomized rats (1982) Prostaglandins, 23, p. 819
- Franchi, González, Gimeno, Gimeno, Progesterone enhances the output of prostaglandin F2-alpha by uterine horns isolated from adult ovariectomized and immature rats (1982) Prostaglandins, 24, p. 775
- Sharma, Fitzpatrick, Effect of estradiol 17 and oxytocin treatment on prostaglandin F alpha release in the anoestrous ewe (1974) Prostaglandins, 6, p. 97
- Caldwell, Tillson, Brock, Speroff, The effects of exogenous progesterone and estradiol on prostaglandin F levels in ovariectemized ewes (1972) Prostaglandins, 1, p. 217
- Challis, Forster, Furr, Robinson, Thorburn, Production of prostaglandin F2α in ewes following luteal regression induced with a prostaglandin analogue, estrumate (Cloprostenol: I.C.I. 80996) (1976) Prostaglandins, 11, p. 537
- Gimeno, Borda, Sterin-Borda, Vidal, Gimeno, Pharmacological influences on human ovarian contractions (1976) Obstet.Gynecol., 47, p. 218
- Coutinho, de Mattos, Effects of estrogen on the motility of the non-atrophic estrogen deficient rabbits uterus (1968) Endocrinology, 83, p. 422
- Boling, Blandeau, The role of estrogen in egg transport through the ampullae of oviducts of castrate rabbit (1971) Fertil. Steril., 22, p. 544
- Gimeno, Bedners, Goldraij, Gimeno, Studies on the contractile activity of myometrium isolated from ovariectomized rats (1970) Acta physiol.latinoam., 20, p. 275
- Conrad, Bioelectrical and contractile behavior of rabbit mesotubarium superius: estrogen withdrawal (1977) Am.J.Physiol., 233, p. C180
- Thorburn, Cox, Currie, Restall, Schneider, prostaglandin F concentration in the utero-ovarian venous plasma of the ewe during the estrous cycle (1972) J. ndocr., 53, p. 525
- Kindahl, Lindell, Edqvist, On the control of prostaglandin release during the bovine estrous cycle. Effects of progesterone implants (1979) Prostaglandins, 18, p. 813
- Wlodawer, Kindahl, Hamberg, Biosynthesis of PGF2α from arachidonic acid and prostaglandin endoperoxides in the uterus (1976) Biochim.Biophys.Acta, 431, p. 603
- Horton, Poyser, Uterine luteolytic hormone: A physiological role for prostaglandin 2α (1976) Physiol.Rev., 56, p. 595
Citas:
---------- APA ----------
Gimeno, A.L., Franchi, A.M., González, E.T. & Gimeno, M.F. (1984) . Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?. Prostaglandins, Leukotrienes and Medicine, 14(2), 289-296.http://dx.doi.org/10.1016/0262-1746(84)90213-0
---------- CHICAGO ----------
Gimeno, A.L., Franchi, A.M., González, E.T., Gimeno, M.F. "Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?" . Prostaglandins, Leukotrienes and Medicine 14, no. 2 (1984) : 289-296.http://dx.doi.org/10.1016/0262-1746(84)90213-0
---------- MLA ----------
Gimeno, A.L., Franchi, A.M., González, E.T., Gimeno, M.F. "Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?" . Prostaglandins, Leukotrienes and Medicine, vol. 14, no. 2, 1984, pp. 289-296.http://dx.doi.org/10.1016/0262-1746(84)90213-0
---------- VANCOUVER ----------
Gimeno, A.L., Franchi, A.M., González, E.T., Gimeno, M.F. Progesterone in vitro and the output of prostaglandin F from the uterus of ovariectomized rats. Priming or withdrawal?. Prostaglandins Leukotrienes Med. 1984;14(2):289-296.http://dx.doi.org/10.1016/0262-1746(84)90213-0
