Artículo
Torres, R.; Modak, B.; Urzúa, A.; Delle Monache, F.; Pujol, E.D.Y.C.A. "Antiviral properties of natural and semi-synthetic compounds from Heliotropium filifolium resin " (2002) Boletin de la Sociedad Chilena de Quimica. 47(3):259-263
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Abstract:
A new compound called filifolinone 3 was synthesized from the unusual spiranic alcohol filifolinol 1, the principal compound isolated from the resinous exudate of Heliotropium filifolium. (fam.Boraginaceae) Both compounds and the ester derivative of 1, filifolinyl senecionate 2 were tested as antiviral agents against five virus species of importance in human diseases. The most active compound resulted 1, specially against polio virus, but with a tight relationship between antiviral dosis/cytotoxic dosis.
Registro:
| Documento: | Artículo |
| Título: | Antiviral properties of natural and semi-synthetic compounds from Heliotropium filifolium resin |
| Autor: | Torres, R.; Modak, B.; Urzúa, A.; Delle Monache, F.; Pujol, E.D.Y.C.A. |
| Filiación: | Depto. de Ciencias del Ambiente, Fac. de Quím. y Biol., Universidad de Santiago de Chile, Avda. Bernardo O'Higgins 3363, Santiago, Chile Ctro. Chimica dei Reccettori del CNR, Istituto di Chimica, Univ. Cattolica del Sacro Cuore, Largo Francesco Vito 1, Roma, Italy Laboratorio de Virología, Departamento de Quím. Biol., Ciudad Universitaria, Buenos Aires, Argentina |
| Palabras clave: | Antiviral properties; Filifolinol; Filifolinone synthesis; Heliotropium filifolium; Resinous exudate; alcohol derivative; ester derivative; filifolinone 3; filifolinyl senecionate 2; heliotropium filifolium extract; plant extract; unclassified drug; antiviral activity; article; controlled study; drug isolation; drug synthesis; Heliotropium; nonhuman; Poliomyelitis virus; virus strain |
| Año: | 2002 |
| Volumen: | 47 |
| Número: | 3 |
| Página de inicio: | 259 |
| Página de fin: | 263 |
| Título revista: | Boletin de la Sociedad Chilena de Quimica |
| Título revista abreviado: | Bol. Soc. Chil. Quim. |
| ISSN: | 03661644 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03661644_v47_n3_p259_Torres |
Referencias:
- Torres, R., Virrarroel, L., Urzúa, A., Delle Monache, F., Delle Monache, G., Gacs-Baitz, E., (1994) Phytochemistry, 36, p. 249
- Urzúa, A., Modak, B., Torres, R., (2001) Bol. Soc. Chil. Quím., 46, p. 175
- Jippo, T., Kamo, O., Nagayana, K., (1986) J. Magn. Reson., 66, p. 344
- Patterson M.K., Jr., (1979) Methods Enzymol., 58, p. 141
- Damonte, E.B., Matulewicz, M.C., Cerezo, A.S., Coto, C.E., (1996) Chemotherapy, 42, p. 57
- Mayashi, K., Niwayana, S., Hagashi, T., Nago, R., Ochiai, H., Morita, N., (1988) Antiviral Res., 9, p. 345
Citas:
---------- APA ----------
Torres, R., Modak, B., Urzúa, A., Delle Monache, F. & Pujol, E.D.Y.C.A. (2002) . Antiviral properties of natural and semi-synthetic compounds from Heliotropium filifolium resin . Boletin de la Sociedad Chilena de Quimica, 47(3), 259-263.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03661644_v47_n3_p259_Torres [ ]
---------- CHICAGO ----------
Torres, R., Modak, B., Urzúa, A., Delle Monache, F., Pujol, E.D.Y.C.A. "Antiviral properties of natural and semi-synthetic compounds from Heliotropium filifolium resin " . Boletin de la Sociedad Chilena de Quimica 47, no. 3 (2002) : 259-263.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03661644_v47_n3_p259_Torres [ ]
---------- MLA ----------
Torres, R., Modak, B., Urzúa, A., Delle Monache, F., Pujol, E.D.Y.C.A. "Antiviral properties of natural and semi-synthetic compounds from Heliotropium filifolium resin " . Boletin de la Sociedad Chilena de Quimica, vol. 47, no. 3, 2002, pp. 259-263.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03661644_v47_n3_p259_Torres [ ]
---------- VANCOUVER ----------
Torres, R., Modak, B., Urzúa, A., Delle Monache, F., Pujol, E.D.Y.C.A. Antiviral properties of natural and semi-synthetic compounds from Heliotropium filifolium resin . Bol. Soc. Chil. Quim. 2002;47(3):259-263.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03661644_v47_n3_p259_Torres [ ]
