Artículo
Mongelli, E.; Pomilio, A.B.; Bustamante Sánchez, J.; Guerra, F.M.; Martínez Massanet, G. "ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum" (2002) Phytotherapy Research. 16(4):387-388
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Abstract:
Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity-directed fractionation, monitored by the BST assay, that led to the isolation of the diterpenoid ent-kaur-16-en-19-oic acid. This compound was potent against the brine shrimp (LC50 = 4.8 μg/mL) and KB cells (IC50 = 1.6 μg/mL). Copyright © 2002 John Wiley & Sons, Ltd.
Registro:
| Documento: | Artículo |
| Título: | ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum |
| Autor: | Mongelli, E.; Pomilio, A.B.; Bustamante Sánchez, J.; Guerra, F.M.; Martínez Massanet, G. |
| Filiación: | PROPLAME-CONICET, Departamento de Química Orǵnica, Universidad de Buenos Aires, (1428), Buenos Aires, Argentina Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Puerto Real, Cádiz, Spain |
| Palabras clave: | Brine shrimp test; Cytotoxicity; Elaeoselinum foetidum; Ent-kaur-16-en-19-oic acid; KB cells; chloroform; colchicine; diterpenoid; DNA; Elaeoselinum foetidum extract; kaurenoic acid; methyl green; plant extract; sodium chloride; unclassified drug; Apiales; article; bioassay; cell strain KB; chromatography; controlled study; drug cytotoxicity; drug DNA interaction; drug exposure; drug isolation; drug potency; drug structure; Elaeoselinum foetidum; fractionation; high performance liquid chromatography; higher plant; human; human cell; IC 50; LC 50; nonhuman; shrimp; structure analysis; toxicity testing; Animals; Antineoplastic Agents, Phytogenic; Apiaceae; Artemia; Carcinoma, Squamous Cell; Cytotoxins; Diterpenes; Humans; Inhibitory Concentration 50; KB Cells; Lethal Dose 50; Molecular Structure; Anostraca; Apiaceae; Decapoda (Crustacea) |
| Año: | 2002 |
| Volumen: | 16 |
| Número: | 4 |
| Página de inicio: | 387 |
| Página de fin: | 388 |
| DOI: | http://dx.doi.org/10.1002/ptr.955 |
| Título revista: | Phytotherapy Research |
| Título revista abreviado: | Phytother. Res. |
| ISSN: | 0951418X |
| CODEN: | PHYRE |
| CAS: | Antineoplastic Agents, Phytogenic; argyrophilic acid, 20316-84-1; Cytotoxins; Diterpenes |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v16_n4_p387_Mongelli |
Referencias:
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Citas:
---------- APA ----------
Mongelli, E., Pomilio, A.B., Bustamante Sánchez, J., Guerra, F.M. & Martínez Massanet, G. (2002) . ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum. Phytotherapy Research, 16(4), 387-388.http://dx.doi.org/10.1002/ptr.955
---------- CHICAGO ----------
Mongelli, E., Pomilio, A.B., Bustamante Sánchez, J., Guerra, F.M., Martínez Massanet, G. "ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum" . Phytotherapy Research 16, no. 4 (2002) : 387-388.http://dx.doi.org/10.1002/ptr.955
---------- MLA ----------
Mongelli, E., Pomilio, A.B., Bustamante Sánchez, J., Guerra, F.M., Martínez Massanet, G. "ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum" . Phytotherapy Research, vol. 16, no. 4, 2002, pp. 387-388.http://dx.doi.org/10.1002/ptr.955
---------- VANCOUVER ----------
Mongelli, E., Pomilio, A.B., Bustamante Sánchez, J., Guerra, F.M., Martínez Massanet, G. ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum. Phytother. Res. 2002;16(4):387-388.http://dx.doi.org/10.1002/ptr.955
