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Abstract:

Gene expression is a key process for memory consolidation. Recently, the participation of epigenetic mechanisms like histone acetylation was evidenced in long-term memories. However, until now the training strength required and the persistence of the chromatin acetylation recruited are not well characterized. Here we studied whether histone acetylation is involved in consolidation in invertebrates, whether it depends on the training strength, and whether it is a permanent or transient mechanism. We used a well-characterized memory model in invertebrates, the context-signal memory in crabs. Our results show no changes in histone 3 (H3) acetylation during consolidation of a standard training protocol. However, strong training induced a significant increase in H3 acetylation 1-h post-training, returning to basal levels afterward. Accordingly, the administration of histone deacetylase inhibitors sodium butyrate (NaB) and trichostatin A allowed a weak training to induce long-term memory. NaB enhanced memory in two phases during consolidation. These findings support that H3 acetylation (1) is involved in consolidation, (2) occurs only after strong training, (3) is a transient process, and (4) memory is enhanced in two phases. The coincidence of these phases with other mechanisms of gene expression is discussed. © 2009 Cold Spring Harbor Laboratory Press.

Registro:

Documento: Artículo
Título:Histone acetylation is recruited in consolidation as a molecular feature of stronger memories
Autor:Federman, N.; Fustiñana, M.S.; Romano, A.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular Y Celular, Ciudad Universitaria, 1428 EHA Buenos Aires, Argentina
Palabras clave:butyric acid; histone; histone H3; trichostatin A; acetylation; animal experiment; animal tissue; article; biological model; chromatin; crab; epigenetics; gene expression regulation; invertebrate; long term memory; male; memory; memory consolidation; molecular interaction; nonhuman; parameter; priority journal; task performance; training; Western blotting
Año:2009
Volumen:16
Número:10
Página de inicio:600
Página de fin:606
DOI: http://dx.doi.org/10.1101/lm.1537009
Título revista:Learning and Memory
Título revista abreviado:Learn. Mem.
ISSN:10720502
CODEN:LEMEF
CAS:butyric acid, 107-92-6, 156-54-7, 461-55-2; histone, 9062-68-4; trichostatin A, 58880-19-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v16_n10_p600_Federman

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Citas:

---------- APA ----------
Federman, N., Fustiñana, M.S. & Romano, A. (2009) . Histone acetylation is recruited in consolidation as a molecular feature of stronger memories. Learning and Memory, 16(10), 600-606.
http://dx.doi.org/10.1101/lm.1537009
---------- CHICAGO ----------
Federman, N., Fustiñana, M.S., Romano, A. "Histone acetylation is recruited in consolidation as a molecular feature of stronger memories" . Learning and Memory 16, no. 10 (2009) : 600-606.
http://dx.doi.org/10.1101/lm.1537009
---------- MLA ----------
Federman, N., Fustiñana, M.S., Romano, A. "Histone acetylation is recruited in consolidation as a molecular feature of stronger memories" . Learning and Memory, vol. 16, no. 10, 2009, pp. 600-606.
http://dx.doi.org/10.1101/lm.1537009
---------- VANCOUVER ----------
Federman, N., Fustiñana, M.S., Romano, A. Histone acetylation is recruited in consolidation as a molecular feature of stronger memories. Learn. Mem. 2009;16(10):600-606.
http://dx.doi.org/10.1101/lm.1537009