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Abstract:

A lipase-catalyzed procedure is described for the preparation of N-hydroxyalkylacrylamides useful among a number of electrophoretical applications such as capillary and gel electrophoresis. The N-hydroxyalkylacrylamides were prepared through an aminolysis reaction of alkanolamines on ethyl acrylate. The reaction was catalyzed by Candida antarctica lipase. The addition of radical inhibitors improved chemoselectivity and amides were obtained in high yield and purity at room temperature. © 2006 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Chemoselective enzymatic preparation of N-hydroxyalkylacrylamides, monomers for hydrophilic polymer matrices
Autor:Rustoy, E.M.; Baldessari, A.
Filiación:Departamento de Química Orgánica, UMYMFOR, Facultad de Ciencias Exacta y Naturales, Pabellon 2, Piso 3, Ciudad Univ, C1428EGA Buenos Aires, Argentina
Palabras clave:Chemoselectivity; Electrophoresis; Lipase; Substituted acrylamides; Electrophoresis; Enzyme kinetics; Enzymes; Hydrophilicity; Monomers; Reaction kinetics; Chemoselective enzymatic preparation; Lipase; N-hydroxyalkylacrylamides; Substituted acrylamides; Nitrogen compounds; acrylamide derivative; polymer; triacylglycerol lipase; aminolysis; article; Candida antarctica; catalysis; chemical reaction; enzyme degradation; gel electrophoresis; hydrophilicity; purification; room temperature; Candida antarctica
Año:2006
Volumen:39
Número:1-4
Página de inicio:50
Página de fin:54
DOI: http://dx.doi.org/10.1016/j.molcatb.2006.01.026
Título revista:Journal of Molecular Catalysis B: Enzymatic
Título revista abreviado:J. Mol. Catal. B Enzym.
ISSN:13811177
CODEN:JMCEF
CAS:triacylglycerol lipase, 9001-62-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13811177_v39_n1-4_p50_Rustoy

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Citas:

---------- APA ----------
Rustoy, E.M. & Baldessari, A. (2006) . Chemoselective enzymatic preparation of N-hydroxyalkylacrylamides, monomers for hydrophilic polymer matrices. Journal of Molecular Catalysis B: Enzymatic, 39(1-4), 50-54.
http://dx.doi.org/10.1016/j.molcatb.2006.01.026
---------- CHICAGO ----------
Rustoy, E.M., Baldessari, A. "Chemoselective enzymatic preparation of N-hydroxyalkylacrylamides, monomers for hydrophilic polymer matrices" . Journal of Molecular Catalysis B: Enzymatic 39, no. 1-4 (2006) : 50-54.
http://dx.doi.org/10.1016/j.molcatb.2006.01.026
---------- MLA ----------
Rustoy, E.M., Baldessari, A. "Chemoselective enzymatic preparation of N-hydroxyalkylacrylamides, monomers for hydrophilic polymer matrices" . Journal of Molecular Catalysis B: Enzymatic, vol. 39, no. 1-4, 2006, pp. 50-54.
http://dx.doi.org/10.1016/j.molcatb.2006.01.026
---------- VANCOUVER ----------
Rustoy, E.M., Baldessari, A. Chemoselective enzymatic preparation of N-hydroxyalkylacrylamides, monomers for hydrophilic polymer matrices. J. Mol. Catal. B Enzym. 2006;39(1-4):50-54.
http://dx.doi.org/10.1016/j.molcatb.2006.01.026