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Abstract:

Perfectly uniform dose distributions over target volumes are almost impossible to achieve in clinical practice, due to surrounding normal tissues dose constraints that are commonly imposed to treatment plans. This article introduces a new approach to compute tumour control probabilities (TCPs) under inhomogeneous dose conditions. The equivalent subvolume model presented here does not assume independence between cell responses and can be derived from any homogeneous dose TCP model. To check the consistency of this model, some natural properties are shown to hold, including the so-called uniform dose theorem. In the spirit of the equivalent uniform dose (EUD) concept introduced by Niemierko (1997, Med. Phys., 24 , 103-110), the probability-EUD is defined. This concept together with the methodology introduced to compute TCPs for inhomogeneous doses is applied to different uniform dose TCP models. As expected, the TCP takes into account the whole dose distribution over the target volume, but it is influenced more strongly by the low-dose regions. Finally, the proposed methodology and other approaches to the inhomogeneous dose scenario are compared. © The author 2008. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.

Registro:

Documento: Artículo
Título:A general tumour control probability model for non-uniform dose distributions
Autor:González, S.J.; Carando, D.G.
Filiación:Instrumentación y Control, UEN, Comisión Nacional de Energía Atómica, Avenida Del Libertador 8250, C1429BNP Ciudad de Buenos Aires, Argentina
Departamento de Matemática, Facultad de Cs. Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Palabras clave:Equivalent uniform dose; Non-uniform dose distribution; Tumor control probability; accuracy; article; cancer control; conception; controlled study; dosimetry; intermethod comparison; low energy radiation; mathematical analysis; mathematical computing; mathematical model; methodology; probability; radiation dose distribution; radiation response; Boron Neutron Capture Therapy; Dose-Response Relationship, Radiation; Humans; Melanoma; Models, Biological; Models, Statistical; Poisson Distribution; Probability; Radiation Dosage; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Skin Neoplasms
Año:2008
Volumen:25
Número:2
Página de inicio:171
Página de fin:184
DOI: http://dx.doi.org/10.1093/imammb/dqn012
Título revista:Mathematical Medicine and Biology
Título revista abreviado:Math. Med. Biol.
ISSN:14778599
CODEN:MMBAB
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14778599_v25_n2_p171_Gonzalez

Referencias:

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Citas:

---------- APA ----------
González, S.J. & Carando, D.G. (2008) . A general tumour control probability model for non-uniform dose distributions. Mathematical Medicine and Biology, 25(2), 171-184.
http://dx.doi.org/10.1093/imammb/dqn012
---------- CHICAGO ----------
González, S.J., Carando, D.G. "A general tumour control probability model for non-uniform dose distributions" . Mathematical Medicine and Biology 25, no. 2 (2008) : 171-184.
http://dx.doi.org/10.1093/imammb/dqn012
---------- MLA ----------
González, S.J., Carando, D.G. "A general tumour control probability model for non-uniform dose distributions" . Mathematical Medicine and Biology, vol. 25, no. 2, 2008, pp. 171-184.
http://dx.doi.org/10.1093/imammb/dqn012
---------- VANCOUVER ----------
González, S.J., Carando, D.G. A general tumour control probability model for non-uniform dose distributions. Math. Med. Biol. 2008;25(2):171-184.
http://dx.doi.org/10.1093/imammb/dqn012