Abstract:
A new study reveals that the serine/arginine-rich splicing factor SC35 is necessary to promote RNA polymerase II elongation in a subset of genes, confirming a bidirectional coupling between transcription and splicing. © 2008 Nature Publishing Group.
Registro:
Documento: |
Artículo
|
Título: | A splicing regulator promotes transcriptional elongation |
Autor: | Fededa, J.P.; Kornblihtt, A.R. |
Filiación: | Laboratorio de Fisiología Y Biología Molecular, IFIByNE-CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina
|
Palabras clave: | arginine; messenger RNA; RNA polymerase II; serine; transcription elongation factor; alternative RNA splicing; chromatin immunoprecipitation; down regulation; enhancer region; gene expression; genetic transcription; microarray analysis; molecular recognition; nonhuman; polyadenylation; priority journal; protein domain; RNA processing; RNA sequence; RNA splicing; Schizosaccharomyces pombe; short survey; Trypanosoma cruzi; Amino Acid Motifs; Animals; Exons; Gene Expression Regulation, Fungal; Humans; Introns; Models, Biological; Nuclear Proteins; Protein Structure, Tertiary; Ribonucleoproteins; RNA Polymerase II; RNA Splicing; RNA-Binding Proteins; Transcription, Genetic |
Año: | 2008
|
Volumen: | 15
|
Número: | 8
|
Página de inicio: | 779
|
Página de fin: | 781
|
DOI: |
http://dx.doi.org/10.1038/nsmb0808-779 |
Título revista: | Nature Structural and Molecular Biology
|
Título revista abreviado: | Nat. Struct. Mol. Biol.
|
ISSN: | 15459993
|
CODEN: | NSMBC
|
CAS: | arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; serine, 56-45-1, 6898-95-9; Nuclear Proteins; Ribonucleoproteins; RNA Polymerase II, EC 2.7.7.-; RNA-Binding Proteins; SFRS2 protein, human, 147153-65-9
|
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15459993_v15_n8_p779_Fededa |
Referencias:
- Graveley, B.R., (2000) RNA, 6, pp. 1197-1211
- Misteli, T., Spector, D.L., (1999) Mol. Cell, 3, pp. 697-705
- Ding, J.H., (2004) EMBO J, 23, pp. 885-896
- Lin, S., Coutinho-Mansfield, G., Wang, D., Shatakshi, P., Fu, X.-D., (2008) Nat. Struct. Mol. Biol, 15, pp. 819-826
- Das, R., (2007) Mol. Cell, 26, pp. 867-881
- Bentley, D.L., (2005) Curr. Opin. Cell Biol, 17, pp. 251-256
- de la Mata, M., (2003) Mol. Cell, 12, pp. 525-532
- Batsche, E., Yaniv, M., Muchardt, C., (2006) Nat. Struct. Mol. Biol, 13, pp. 22-29
- Fong, Y.W., Zhou, Q., (2001) Nature, 414, pp. 929-933
- Wang, J., Smith, P.J., Krainer, A.R., Zhang, M.Q., (2005) Nucleic Acids Res, 33, pp. 5053-5062
- Webb, C.J., Romfo, C.M., van Heeckeren, W.J., Wise, J.A., (2005) Genes Dev, 19, pp. 242-254
- Portal, D., (2003) Mol. Biochem. Parasitol, 127, pp. 37-46
- Medlin, J., (2005) EMBO J, 24, pp. 4154-4165
- Caceres, J.F., Screaton, G.R., Krainer, A.R., (1998) Genes Dev, 12, pp. 55-66
- Sanford, J.R., Gray, N.K., Beckmann, K., Caceres, J.F., (2004) Genes Dev, 18, pp. 755-768
Citas:
---------- APA ----------
Fededa, J.P. & Kornblihtt, A.R.
(2008)
. A splicing regulator promotes transcriptional elongation. Nature Structural and Molecular Biology, 15(8), 779-781.
http://dx.doi.org/10.1038/nsmb0808-779---------- CHICAGO ----------
Fededa, J.P., Kornblihtt, A.R.
"A splicing regulator promotes transcriptional elongation"
. Nature Structural and Molecular Biology 15, no. 8
(2008) : 779-781.
http://dx.doi.org/10.1038/nsmb0808-779---------- MLA ----------
Fededa, J.P., Kornblihtt, A.R.
"A splicing regulator promotes transcriptional elongation"
. Nature Structural and Molecular Biology, vol. 15, no. 8, 2008, pp. 779-781.
http://dx.doi.org/10.1038/nsmb0808-779---------- VANCOUVER ----------
Fededa, J.P., Kornblihtt, A.R. A splicing regulator promotes transcriptional elongation. Nat. Struct. Mol. Biol. 2008;15(8):779-781.
http://dx.doi.org/10.1038/nsmb0808-779