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Colombo, L.; González, G.; Marshall, G.; Molina, F.V.; Soba, A.; Suarez, C.; Turjanski, P. "Ion transport in tumors under electrochemical treatment: In vivo, in vitro and in silico modeling" (2007) Bioelectrochemistry. 71(2):223-232
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Abstract:

The electrochemical treatment of cancer (EChT) consists in the passage of a direct electric current through two or more electrodes inserted locally in the tumor tissue. The extreme pH changes induced have been proposed as the main tumor destruction mechanism. Here, we study ion transport during EChT through a combined modeling methodology: in vivo modeling with BALB/c mice bearing a subcutaneous tumor, in vitro modeling with agar and collagen gels, and in silico modeling using the one-dimensional Nernst-Planck and Poisson equations for ion transport in a four-ion electrolyte. This combined modeling approach reveals that, under EChT modeling, an initial condition with almost neutral pH evolves between electrodes into extreme cathodic alkaline and anodic acidic fronts moving towards each other, leaving the possible existence of a biological pH region between them; towards the periphery, the pH decays to its neutral values. pH front tracking unveils a time scaling close to t1/2, signature of a diffusion-controlled process. These results could have significant implications in EChT optimal operative conditions and dose planning, in particular, in the way in which the evolving EChT pH region covers the active cancer cells spherical casket. © 2007 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Ion transport in tumors under electrochemical treatment: In vivo, in vitro and in silico modeling
Autor:Colombo, L.; González, G.; Marshall, G.; Molina, F.V.; Soba, A.; Suarez, C.; Turjanski, P.
Filiación:Depto. de Inmunobiología, Inst. de Oncología Angel H. Roffo, Universidad de Buenos Aires, C1417DTB Buenos Aires, Argentina
Laboratorio de Sistemas Complejos, Departamento de Computación, FCEyN, C1428EGA Buenos Aires, Argentina
INQUIMAE, FCEyN, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
Palabras clave:Computational modeling; Electrochemical treatment; Ion transport; Tumors; Charge transfer; Collagen; Computational methods; Electric currents; Electrochemistry; Electrodes; Patient treatment; Computational modeling; Electrochemical treatment; Ion transport; Poisson equations; Tumors; agar; collagen gel; electrolyte; acidity; alkalinity; animal experiment; animal model; article; Bagg albino mouse; cancer model; computer model; controlled study; electric current; electrochemistry; electrode; human; human cell; in vitro study; in vivo study; ion transport; male; mouse; nonhuman; pH; subcutaneous tissue tumor; Animals; Computational Biology; Electric Conductivity; Electric Stimulation; Electrochemistry; Electrodes; Female; Humans; Hydrogen-Ion Concentration; Ion Transport; Mice; Mice, Inbred BALB C; Models, Biological; Necrosis; Neoplasms; Mus
Año:2007
Volumen:71
Número:2
Página de inicio:223
Página de fin:232
DOI: http://dx.doi.org/10.1016/j.bioelechem.2007.07.001
Título revista:Bioelectrochemistry
Título revista abreviado:Bioelectrochemistry
ISSN:15675394
CODEN:BIOEF
CAS:agar, 9002-18-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15675394_v71_n2_p223_Colombo

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Citas:

---------- APA ----------
Colombo, L., González, G., Marshall, G., Molina, F.V., Soba, A., Suarez, C. & Turjanski, P. (2007) . Ion transport in tumors under electrochemical treatment: In vivo, in vitro and in silico modeling. Bioelectrochemistry, 71(2), 223-232.
http://dx.doi.org/10.1016/j.bioelechem.2007.07.001
---------- CHICAGO ----------
Colombo, L., González, G., Marshall, G., Molina, F.V., Soba, A., Suarez, C., et al. "Ion transport in tumors under electrochemical treatment: In vivo, in vitro and in silico modeling" . Bioelectrochemistry 71, no. 2 (2007) : 223-232.
http://dx.doi.org/10.1016/j.bioelechem.2007.07.001
---------- MLA ----------
Colombo, L., González, G., Marshall, G., Molina, F.V., Soba, A., Suarez, C., et al. "Ion transport in tumors under electrochemical treatment: In vivo, in vitro and in silico modeling" . Bioelectrochemistry, vol. 71, no. 2, 2007, pp. 223-232.
http://dx.doi.org/10.1016/j.bioelechem.2007.07.001
---------- VANCOUVER ----------
Colombo, L., González, G., Marshall, G., Molina, F.V., Soba, A., Suarez, C., et al. Ion transport in tumors under electrochemical treatment: In vivo, in vitro and in silico modeling. Bioelectrochemistry. 2007;71(2):223-232.
http://dx.doi.org/10.1016/j.bioelechem.2007.07.001