Artículo

Sundblad, V.; Quintar, A.A.; Morosi, L.G.; Niveloni, S.I.; Cabanne, A.; Smecuol, E.; Mauriño, E.; Mariño, K.V.; Bai, J.C.; Maldonado, C.A.; Rabinovich, G.A. "Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients" (2018) Frontiers in Immunology. 9(MAR)
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Abstract:

Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course of innate and adaptive immune responses. Through interaction with a wide range of glycosylated receptors bearing complex branched N-glycans and core 2-O-glycans, these endogenous lectins trigger distinct signaling programs thereby controling immune cell activation, differentiation, recruitment and survival. Given the unique features of mucosal inflammation and the differential expression of galectins throughout the gastrointestinal tract, we discuss here key findings on the role of galectins in intestinal inflammation, particularly Crohn's disease, ulcerative colitis, and celiac disease (CeD) patients, as well as in murine models resembling these inflammatory conditions. In addition, we present new data highlighting the regulated expression of galectin-1 (Gal-1), a proto-type member of the galectin family, during intestinal inflammation in untreated and treated CeD patients. Our results unveil a substantial upregulation of Gal-1 accompanying the anti-inflammatory and tolerogenic response associated with gluten-free diet in CeD patients, suggesting a major role of this lectin in favoring resolution of inflammation and restoration of mucosal homeostasis. Thus, a coordinated network of galectins and their glycosylated ligands, exerting either anti-inflammatory or proinflammatory responses, may influence the interplay between intestinal epithelial cells and the highly specialized gut immune system in physiologic and pathologic settings. © 2018 Sundblad, Quintar, Morosi, Niveloni, Cabanne, Smecuol, Mauriño, Mariño, Bai, Maldonado and Rabinovich.

Registro:

Documento: Artículo
Título:Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
Autor:Sundblad, V.; Quintar, A.A.; Morosi, L.G.; Niveloni, S.I.; Cabanne, A.; Smecuol, E.; Mauriño, E.; Mariño, K.V.; Bai, J.C.; Maldonado, C.A.; Rabinovich, G.A.
Filiación:Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Centro de Microscopía Electrónica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina
Instituto de Investigaciones en Ciencias de la Salud (INICSA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina
Laboratorio de Glicómica Funcional y Molecular, Instituto de Biología y Medicina Experimental (IBYME), Consejo de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Sección Intestino Delgado, Departamento de Medicina, Hospital de Gastroenterología Dr. C. Bonorino Udaondo, Buenos Aires, Argentina
Unidad de Patología, Hospital de Gastroenterología, Bonorino Udaondo, Buenos Aires, Argentina
Instituto de Investigaciones, Universidad del Salvador, Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Celiac disease; Galectin-1; Galectins; Glycans; Gut inflammation; Inflammatory bowel disease; galectin 1; trinitrobenzenesulfonic acid; animal model; animal tissue; apoptosis; Article; celiac disease; cell differentiation; cell maturation; cell migration; cell survival; cell viability; colitis; enteritis; gluten free diet; human; immune system; immunity; immunogenicity; inflammatory bowel disease; nervous system inflammation; nonhuman; protein expression; risk factor; trinitrobenzene sulfonic acid-induced colitis
Año:2018
Volumen:9
Número:MAR
DOI: http://dx.doi.org/10.3389/fimmu.2018.00379
Título revista:Frontiers in Immunology
Título revista abreviado:Front. Immunol.
ISSN:16643224
CAS:galectin 1, 258495-34-0; trinitrobenzenesulfonic acid, 16655-63-3, 2508-19-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16643224_v9_nMAR_p_Sundblad

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Citas:

---------- APA ----------
Sundblad, V., Quintar, A.A., Morosi, L.G., Niveloni, S.I., Cabanne, A., Smecuol, E., Mauriño, E.,..., Rabinovich, G.A. (2018) . Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients. Frontiers in Immunology, 9(MAR).
http://dx.doi.org/10.3389/fimmu.2018.00379
---------- CHICAGO ----------
Sundblad, V., Quintar, A.A., Morosi, L.G., Niveloni, S.I., Cabanne, A., Smecuol, E., et al. "Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients" . Frontiers in Immunology 9, no. MAR (2018).
http://dx.doi.org/10.3389/fimmu.2018.00379
---------- MLA ----------
Sundblad, V., Quintar, A.A., Morosi, L.G., Niveloni, S.I., Cabanne, A., Smecuol, E., et al. "Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients" . Frontiers in Immunology, vol. 9, no. MAR, 2018.
http://dx.doi.org/10.3389/fimmu.2018.00379
---------- VANCOUVER ----------
Sundblad, V., Quintar, A.A., Morosi, L.G., Niveloni, S.I., Cabanne, A., Smecuol, E., et al. Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients. Front. Immunol. 2018;9(MAR).
http://dx.doi.org/10.3389/fimmu.2018.00379