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Abstract:

Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd.

Registro:

Documento: Artículo
Título:Novel therapeutic targets for arenavirus hemorrhagic fevers
Autor:Garca, C.C.; Seplveda, C.S.; Damonte, E.B.
Filiación:Laboratorio de Virologa, Departamento de Qumica Biolgica, Universidad de Buenos Aires, Pabelln 2, 1428 Buenos Aires, Argentina
Palabras clave:antiviral agent; arenavirus; junin virus; Lassa virus; therapeutic target; viral hemorrhagic fevers; acridone derivative; antivirus agent; brassinosteroid; candid 1; cell enzyme; cholesterol; disulfiram; epiandrosterone; ESCRT protein; fatty acid; favipiravir; fluorouracil; n myristolyltransferase; phosphatidylserine; prasterone; ribavirin; st 193; st 194; unclassified drug; virus protein; virus RNA; virus vaccine; virus z protein; arenavirus hemorrhagic fever; Argentine hemorrhagic fever; article; drug targeting; human; infection control; Junin virus; Lassa virus; nonhuman; priority journal; virion; virus envelope; virus genome; virus hemorrhagic fever; Arenaviridae; Arenavirus; Junin virus; Lassa virus
Año:2011
Volumen:6
Número:1
Página de inicio:27
Página de fin:44
DOI: http://dx.doi.org/10.2217/fvl.10.65
Título revista:Future Virology
Título revista abreviado:Future Virol.
ISSN:17460794
CAS:cholesterol, 57-88-5; disulfiram, 97-77-8; epiandrosterone, 481-29-8; favipiravir, 259793-96-9; fluorouracil, 51-21-8; prasterone, 53-43-0; ribavirin, 36791-04-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17460794_v6_n1_p27_Garca

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Citas:

---------- APA ----------
Garca, C.C., Seplveda, C.S. & Damonte, E.B. (2011) . Novel therapeutic targets for arenavirus hemorrhagic fevers. Future Virology, 6(1), 27-44.
http://dx.doi.org/10.2217/fvl.10.65
---------- CHICAGO ----------
Garca, C.C., Seplveda, C.S., Damonte, E.B. "Novel therapeutic targets for arenavirus hemorrhagic fevers" . Future Virology 6, no. 1 (2011) : 27-44.
http://dx.doi.org/10.2217/fvl.10.65
---------- MLA ----------
Garca, C.C., Seplveda, C.S., Damonte, E.B. "Novel therapeutic targets for arenavirus hemorrhagic fevers" . Future Virology, vol. 6, no. 1, 2011, pp. 27-44.
http://dx.doi.org/10.2217/fvl.10.65
---------- VANCOUVER ----------
Garca, C.C., Seplveda, C.S., Damonte, E.B. Novel therapeutic targets for arenavirus hemorrhagic fevers. Future Virol. 2011;6(1):27-44.
http://dx.doi.org/10.2217/fvl.10.65