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Abstract:

Aim: An adventitia dependent regulation of the vascular smooth muscle tone has been described. However, if the adventitia plays an active role on arterial wall biomechanical behaviour and functions remains to be established. Our aim was to characterize the influence of adventitia on arterial wall mechanical properties and the arterial conduit and buffer functions. Methods: Ovine brachiocephalic arteries were studied in vivo (n = 8) and in vitro (with null tone) in a circulation mock (n = 8). Isobaric, isoflow and isofrequency studies were performed. In each segment, pressure and diameter waves were assessed before and after adventitia removal. From the arterial stress-strain relationship, we derived the elastic and the viscous modulus. The buffering and conduit functions were calculated using the Kelvin-Voigt's time constant and the inverse of the characteristic impedance, respectively. Results: In in vivo studies arterial diameter decreased after adventitia removal (P < 0.05). Elastic and viscous modulus in in vivo studies were significantly higher in adventitia-removed arteries, compared with values in intact vessels (P < 0.05). This behaviour was not observed in in vitro experiments. An impairment of buffer and conduit functions was observed in vivo after adventitia removal (P < 0.05), while both functions remain unchanged in in vitro studies (P > 0.05). Conclusions: Arterial wall viscosity and elasticity were influenced by adventitia removal in in vivo studies, possibly by a smooth muscle-dependent mechanism, since it was not present in in vitro experiments. Adventitia would be involved in a physiological mechanism of arterial wall viscous and elastic properties regulation, that could influence arterial buffering and conduit functions. © 2006 Scandinavian Physiological Society.

Registro:

Documento: Artículo
Título:Adventitia-dependent mechanical properties of brachiocephalic ovine arteries in in vivo and in vitro studies
Autor:Cabrera Fischer, E.I.; Bia, D.; Camus, J.M.; Zócalo, Y.; De Forteza, E.; Armentano, R.L.
Filiación:Facultad de Ingeniería, Ciencias Exactas Y Naturales, Favaloro University, Solís 453, Buenos Aires, Argentina
Physiology Department, School of Medicine, Universidad de la República, Montevideo, Uruguay
Research Career, CONICET, Buenos Aires, Argentina
Physiology Department, School of Medicine, Republic University, General Flores 2125, PC 11800, Montevideo, Uruguay
Idioma: Inglés
Palabras clave:Adventitial function; Arterial buffering function; Arterial conduit function; Elastic modulus; Viscous modulus; adventitia; animal experiment; animal tissue; arterial circulation; artery diameter; artery tone; artery wall; article; brachiocephalic trunk; controlled study; impedance; in vitro study; in vivo study; male; nonhuman; priority journal; pulse wave; sheep; stress strain relationship; Animals; Brachiocephalic Trunk; Connective Tissue; Elasticity; Male; Models, Biological; Muscle, Smooth, Vascular; Sheep, Domestic; Tissue Culture Techniques; Transducers, Pressure; Viscosity
Año:2006
Volumen:188
Número:2
Página de inicio:103
Página de fin:111
DOI: http://dx.doi.org/10.1111/j.1748-1716.2006.01614.x
Título revista:Acta Physiologica
Título revista abreviado:Acta Physiol.
ISSN:17481708
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_17481708_v188_n2_p103_CabreraFischer

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Citas:

---------- APA ----------
Cabrera Fischer, E.I., Bia, D., Camus, J.M., Zócalo, Y., De Forteza, E. & Armentano, R.L. (2006) . Adventitia-dependent mechanical properties of brachiocephalic ovine arteries in in vivo and in vitro studies. Acta Physiologica, 188(2), 103-111.
http://dx.doi.org/10.1111/j.1748-1716.2006.01614.x
---------- CHICAGO ----------
Cabrera Fischer, E.I., Bia, D., Camus, J.M., Zócalo, Y., De Forteza, E., Armentano, R.L. "Adventitia-dependent mechanical properties of brachiocephalic ovine arteries in in vivo and in vitro studies" . Acta Physiologica 188, no. 2 (2006) : 103-111.
http://dx.doi.org/10.1111/j.1748-1716.2006.01614.x
---------- MLA ----------
Cabrera Fischer, E.I., Bia, D., Camus, J.M., Zócalo, Y., De Forteza, E., Armentano, R.L. "Adventitia-dependent mechanical properties of brachiocephalic ovine arteries in in vivo and in vitro studies" . Acta Physiologica, vol. 188, no. 2, 2006, pp. 103-111.
http://dx.doi.org/10.1111/j.1748-1716.2006.01614.x
---------- VANCOUVER ----------
Cabrera Fischer, E.I., Bia, D., Camus, J.M., Zócalo, Y., De Forteza, E., Armentano, R.L. Adventitia-dependent mechanical properties of brachiocephalic ovine arteries in in vivo and in vitro studies. Acta Physiol. 2006;188(2):103-111.
http://dx.doi.org/10.1111/j.1748-1716.2006.01614.x