Artículo

Ibanez, A.; Urquina, H.; Petroni, A.; Baez, S.; Lopez, V.; do Nascimento, M.; Herrera, E.; Guex, R.; Hurtado, E.; Blenkmann, A.; Beltrachini, L.; Gelormini, C.; Sigman, M.; Lischinsky, A.; Torralva, T.; Torrente, F.; Cetkovich, M.; Manes, F. "Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)" (2012) PLoS ONE. 7(10)
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Abstract:

Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). Conclusions/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments. © 2012 Ibanez et al.

Registro:

Documento: Artículo
Título:Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
Autor:Ibanez, A.; Urquina, H.; Petroni, A.; Baez, S.; Lopez, V.; do Nascimento, M.; Herrera, E.; Guex, R.; Hurtado, E.; Blenkmann, A.; Beltrachini, L.; Gelormini, C.; Sigman, M.; Lischinsky, A.; Torralva, T.; Torrente, F.; Cetkovich, M.; Manes, F.
Filiación:Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina
National Scientific and Technical Research Council, Buenos Aires, Argentina
Universidad Diego Portales, Santiago, Chile
Integrative Neuroscience Laboratory, Physics Department, University of Buenos Aires, Buenos Aires, Argentina
Pontificia Universidad Católica de Chile, Santiago, Chile
Epilepsy Center, University of Buenos Aires - National Scientific and Technical Research Council, University of Buenos Aires, Buenos Aires, Argentina
Laboratory of Industrial Electronics, Control and Instrumentation, National University of La Plata, La Plata, Argentina
Universidad Autónoma del Caribe, Barranquilla, Colombia
Pontificia Universidad Católica Argentina, Buenos Aires, Argentina
Grupo de Investigación Neurored, Universidad Surcolombiana, Neiva, Colombia
Laboratory for Behavioral Neurology and Imaging of Cognition, University of Geneva, Geneva, Switzerland
Palabras clave:adult; anger; article; bipolar disorder; clinical article; controlled study; depression; dual valence task; emotion; event related potential; facial expression; female; fusiform face area; fusiform gyrus; happiness; human; impulsiveness; male; mania; neuropsychological test; questionnaire; right handedness; semantic memory; social cognition; State Trait Anxiety Inventory; stimulus response; task performance; theory of mind; Acoustic Stimulation; Adult; Behavior; Bipolar Disorder; Emotions; Evoked Potentials; Facial Expression; Female; Humans; Male; Neuropsychological Tests; Photic Stimulation; Recognition (Psychology); Semantics; Theory of Mind
Año:2012
Volumen:7
Número:10
DOI: http://dx.doi.org/10.1371/journal.pone.0046877
Título revista:PLoS ONE
Título revista abreviado:PLoS ONE
ISSN:19326203
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v7_n10_p_Ibanez

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Citas:

---------- APA ----------
Ibanez, A., Urquina, H., Petroni, A., Baez, S., Lopez, V., do Nascimento, M., Herrera, E.,..., Manes, F. (2012) . Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM). PLoS ONE, 7(10).
http://dx.doi.org/10.1371/journal.pone.0046877
---------- CHICAGO ----------
Ibanez, A., Urquina, H., Petroni, A., Baez, S., Lopez, V., do Nascimento, M., et al. "Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)" . PLoS ONE 7, no. 10 (2012).
http://dx.doi.org/10.1371/journal.pone.0046877
---------- MLA ----------
Ibanez, A., Urquina, H., Petroni, A., Baez, S., Lopez, V., do Nascimento, M., et al. "Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)" . PLoS ONE, vol. 7, no. 10, 2012.
http://dx.doi.org/10.1371/journal.pone.0046877
---------- VANCOUVER ----------
Ibanez, A., Urquina, H., Petroni, A., Baez, S., Lopez, V., do Nascimento, M., et al. Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM). PLoS ONE. 2012;7(10).
http://dx.doi.org/10.1371/journal.pone.0046877