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drug activity
63
"Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors" (2018) Martínez, M.D.;Ghini, A.A.;Dansey, M.V. (...)Burton, G. Bioorganic and Medicinal Chemistry. 26(5):1092-1101
"Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase" (2016) Rodriguez, J.B.; Falcone, B.N.; Szajnman, S.H. Expert Opinion on Drug Discovery. 11(3):307-320
"Mode of action of the sesquiterpene lactones psilostachyin and psilostachyin C on trypanosoma cruzi" (2016) Sülsen, V.P.;Puente, V.;Papademetrio, D. (...)Lombardo, M.E. PLoS ONE. 11(3)
"Effect of synthetic steroids on GABAA receptor binding in rat brain" (2015) Rey, M.;Veleiro, A.S.;Ghini, A.A. (...)Coirini, H. Neuroscience. 290:138-146
"Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway" (2015) Bueno, C.A.;Michelini, F.M.;Pertino, M.W. (...)Alché, L.E. Medical Microbiology and Immunology. 204(5):575-584
"Synthesis and biological evaluation of salpichrolide analogs as antiestrogenic agents" (2014) Sonego, J.M.;Rivero, E.M.;Gargiulo, L. (...)Burton, G. European Journal of Medicinal Chemistry. 82:233-241
"In vitro effect of 5-fluorouracil and paclitaxel on Echinococcus granulosus larvae and cells" (2014) Pensel, P.E.;Albani, C.;Gamboa, G.U. (...)Elissondo, M.C. Acta Tropica. 140:1-9
"New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase" (2014) Ferrer-Casal, M.;Li, C.;Galizzi, M. (...)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 22(1):398-405
"Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones" (2014) Martins Alho, M.A.;Marrero-Ponce, Y.;Barigye, S.J. (...)Arán, V.J. Bioorganic and Medicinal Chemistry. 22(5):1568-1585
"In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from red seaweed Nemalion helminthoides" (2014) Pérez-Recalde, M.; Matulewicz, M.C.; Pujol, C.A.; Carlucci, M.J. International Journal of Biological Macromolecules. 63:38-42
"Preparation and antitrypanosomal activity of secochiliolide acid derivatives" (2013) Siless, G.E.;Lozano, E.;Sánchez, M. (...)Palermo, J.A. Bioorganic and Medicinal Chemistry Letters. 23(17):4964-4967
"Antiparasitic hybrids of Cinchona alkaloids and bile acids" (2013) Leverrier, A.;Bero, J.;Frédérich, M. (...)Palermo, J. European Journal of Medicinal Chemistry. 66:355-363
"Trypanocidal activity of thioamide-substituted imidazoquinolinone: Electrochemical properties and biological effects" (2013) Frank, F.M.;Ciccarelli, A.B.;Bollini, M. (...)Lombardo, M.E. Evidence-based Complementary and Alternative Medicine. 2013
"Opposite actions of dopamine on aversive and appetitive memories in the crab" (2012) Klappenbach, M.; Maldonado, H.; Locatelli, F.; Kaczer, L. Learning and Memory. 19(2):73-83
"Synthesis of aromatic stigmastanes: Application to the synthesis of aromatic analogs of brassinosteroids" (2012) Acebedo, S.L.; Alonso, F.; Ramírez, J.A.; Galagovsky, L.R. Tetrahedron. 68(19):3685-3691
"System among the corticosteroids: Specificity and molecular dynamics" (2012) Brookes, J.C.;Galigniana, M.D.;Harker, A.H. (...)Vinson, G.P. Journal of the Royal Society Interface. 9(66):43-53
"1,2,4-Triazole d-ribose derivatives: Design, synthesis and antitumoral evaluation" (2012) Avanzo, R.E.;Anesini, C.;Fascio, M.L. (...)D'Accorso, N.B. European Journal of Medicinal Chemistry. 47(1):104-110
"Synthesis and acetylcholinesterase inhibitory activity of 2β,3α-disulfoxy-5α-cholestan-6-one" (2011) Richmond, V.; Santos, G.A.G.; Murray, A.P.; Maier, M.S. Steroids. 76(10-11):1160-1165
"Differential neonatal testosterone imprinting of GH-dependent liver proteins and genes in female mice" (2010) Ramirez, M.C.; Luque, G.M.; Ornstein, A.M.; Becu-Villalobos, D. Journal of Endocrinology. 207(3):301-308
"Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol" (2010) Bonifazi, E.L.;Ríos-Luci, C.;León, L.G. (...)Misico, R.I. Bioorganic and Medicinal Chemistry. 18(7):2621-2630
"1-Cinnamoyl-3,11-dihydroxymeliacarpin delays glycoprotein transport restraining virus multiplication without cytotoxicity" (2010) Bueno, C.A.; Alché, L.E.; Barquero, A.A. Biochemical and Biophysical Research Communications. 393(1):32-37
"Allopregnanolone (3α-Hydroxy-5α-pregnan-20-one) derivatives with a polar chain in position 16α: Synthesis and activity" (2009) Slavíková, B.;Krištofíková, Z.;Chodounská, H. (...)Kasal, A. Journal of Medicinal Chemistry. 52(7):2119-2125
"Anti-herpetic and anti-inflammatory activities of two new synthetic 22,23-dihydroxylated stigmastane derivatives" (2008) Michelini, F.M.;Ramírez, J.A.;Berra, A. (...)Alché, L.E. Journal of Steroid Biochemistry and Molecular Biology. 111(1-2):111-116
"Steroid protection in the experimental autoimmune encephalomyelitis model of multiple sclerosis" (2008) Garay, L.;Gonzalez Deniselle, M.C.;Gierman, L. (...)De Nicola, A.F. NeuroImmunoModulation. 15(1):76-83
"Syntheses of immunomodulating androstanes and stigmastanes: Comparison of their TNF-α inhibitory activity" (2007) Ramírez, J.A.;Bruttomesso, A.C.;Michelini, F.M. (...)Galagovsky, L.R. Bioorganic and Medicinal Chemistry. 15(24):7538-7544
"Synthesis of novel carbohydrate acridinone derivatives with potential biological activities using 1,3-dipolar cycloaddition" (2007) Fascio, M.L.; D'Accorso, N.B.; Pellón, R.F.; Docampo, M.L. Synthetic Communications. 37(23):4209-4217
"Bioactivity of Scytonema hofmanni (Cyanobacteria) in Lilium alexandrae in vitro propagation" (2006) Zaccaro, M.C.;Kato, A.;Zulpa, G. (...)Stella, A.M. Electronic Journal of Biotechnology. 9(3):210-214
"Synthesis and bioactivity of C-29 brassinosteroid analogues with different functional groups at C-6" (2005) Ramírez, J.A.; Brosa, C.; Galagovsky, L.R. Phytochemistry. 66(5):581-587
"Further evidence on the role of heparan sulfate as protamine acceptor during the decondensation of human spermatozoa" (2005) Romanato, M.;Regueira, E.;Cameo, M.S. (...)Calvo, J.C. Human Reproduction. 20(10):2784-2789
"Activity and stability of hammerhead ribozymes containing 2′-C-methyluridine: A new RNA mimic" (2005) Gallo, M.; Far, R.K.-K.; Sczakiel, G.; Iribarren, A.M. Chemistry and Biodiversity. 2(2):198-204
"6,19-Sulfur-bridged progesterone analogues with antiimmunosuppressive activity" (2005) Veleiro, A.S.;Pecci, A.;Monteserín, M.C. (...)Burton, G. Journal of Medicinal Chemistry. 48(18):5675-5683
"Mixtures of natural and synthetic antifungal agents" (2005) López-Malo, A.; Palou, E.; León-Cruz, R.; Alzamora, S.M. Advances in Experimental Medicine and Biology. 571:261-286
"Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata" (2004) Talarico, L.B.;Zibetti, R.G.M.;Faria, P.C.S. (...)Damonte, E.B. International Journal of Biological Macromolecules. 34(1-2):63-71
"In vitro anti-herpetic activity of sulfated polysaccharide fractions from Caulerpa racemosa" (2004) Ghosh, P.;Adhikari, U.;Ghosal, P.K. (...)Ray, B. Phytochemistry. 65(23):3151-3157
"Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABA ρ1 receptor" (2004) Goutman, J.D.; Calvo, D.J. British Journal of Pharmacology. 141(4):717-727
"5-Methylcoumaranones from Mutisia friesiana and their bioactivity" (2004) Viturro, C.I.; De La Fuente, J.R.; Maier, M.S. Journal of Natural Products. 67(5):778-782
"Lipase-catalyzed preparation of biologically active esters of dehydroepiandrosterone" (2004) Bruttomesso, A.C.; Tiscornia, A.; Baldessari, A. Biocatalysis and Biotransformation. 22(3):215-220
"Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease" (2003) Urbina, J.A.;Concepcion, J.L.;Montalvetti, A. (...)Docampo, R. Antimicrobial Agents and Chemotherapy. 47(6):2047-2050
"Enterocin CRL35 inhibits late stages of HSV-1 and HSV-2 replication in vitro" (2003) Wachsman, M.B.;Castilla, V.;De Ruiz Holgado, A.P. (...)Coto, C.E. Antiviral Research. 58(1):17-24
"Synthesis and GABAA receptor activity of a 6,19-oxido analogue of pregnanolone" (2003) Veleiro, A.S.;Rosenstein, R.E.;Jaliffa, C.O. (...)Burton, G. Bioorganic and Medicinal Chemistry Letters. 13(3):343-346
"Differential inhibitory action of two azoic compounds against arenaviruses" (2003) García, C.C.; Candurra, N.A.; Damonte, E.B. International Journal of Antimicrobial Agents. 21(4):319-324
"Heparan sulphate: A putative decondensing agent for human spermatozoa in vivo" (2003) Romanato, M.;Cameo, M.S.;Bertolesi, G. (...)Calvo, L. Human Reproduction. 18(9):1868-1873
"Enzyme-catalyzed preparation of novel fatty acid derivatives of pyridoxine with surfactant activity" (2002) Baldessari, A.; Mangone, C.P. Biocatalysis and Biotransformation. 20(4):275-279
"Expression and structure-function analysis of DE, a sperm cysteine-rich secretory protein that mediates gamete fusion" (2002) Ellerman, D.A.;Da Ros, V.G.;Cohen, D.J. (...)Cuasnicú, P.S. Biology of Reproduction. 67(4):1225-1231
"How does hexachlorobenzene treatment affect liver uroporphyrinogen decarboxylase?" (2001) Chaufan, G.; Del Carmen Ríos de Molina, M.; San Martín de Viale, L.C. International Journal of Biochemistry and Cell Biology. 33(6):621-630
"Synthesis and characterization of some N-heterocyclic carbohydrate derivatives" (2000) Alho, M.A.M.; D'Accorso, N.B. Molecules. 5(3):381-382
"Bioactive constituents of Conyza albida" (2000) Del Pacciaroni, A.V.;Mongelli, E.;Espinar, L.A. (...)Silva, G.L. Planta Medica. 66(8):720-723
"Synthesis of heterocylic compounds of biological interest from carbohydrate derivatives" (2000) Martinez Esperón, M.F.; Fascio, M.L.; D'Accorso, N.B. Molecules. 5(3):418-419
"Mechanism of action of the potent sodium-retaining steroid 11,19- oxidoprogesterone" (2000) Galigniana, M.D.;Vicent, G.P.;Piwien-Pilipuk, G. (...)Lantos, C.P. Molecular Pharmacology. 58(1):58-70
"Bioactive metabolites produced by fungi cultures" (2000) Levy, L.M.; Cabrera, G.M.; Wright, J.E.; Seldes, A.M. Molecules. 5(3):354-355
"Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C" (1999) Comin, M.J.; Pujol, C.A.; Damonte, E.B.; Rodriguez, J.B. Nucleosides and Nucleotides. 18(10):2219-2231
"Immunomodulatory activities of Melia azedarach L. leaf extracts on human monocytes" (1997) Benencia, F.; Courrèges, M.C.; Coto, C.E.; Coulombié, F.C. Journal of Herbs, Spices and Medicinal Plants. 5(3):7-13
"Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb" (1995) Schvartzapel, A.J.;Fichera, L.;Esteva, M. (...)Gros, E.G. Helvetica Chimica Acta. 78(5):1207-1214
"Antitumor and cytotoxic screen of 5,6,7-trisubstituted flavones from Gomphrena martiana" (1994) Pomilio, A.B.; Rutty Solá, G.A.; Mayer, A.M.S.; Rumi, L.S. Journal of Ethnopharmacology. 44(1):25-33
"Studies to determine the possible antitumoral properties of Cobra venom and of Crotoxin Complex A and B" (1988) Baldi, A.;Mordoh, J.;Medrano, E.E. (...)Rumi, L. Medicina. 48(4):337-344