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drug design
77
"Further insights of selenium-containing analogues of WC-9 against Trypanosoma cruzi"
(2019) Chao, M.N.;Lorenzo-Ocampo, M.V.;Szajnman, S.H. (
...
)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 27(7):1350-1361
"Synthesis and biological evaluation of new quinoline derivatives as antileishmanial and antitrypanosomal agents"
(2019) Chanquia, S.N.;Larregui, F.;Puente, V. (
...
)García Liñares, G. Bioorganic Chemistry. 83:526-534
"The Role of the Phosphorus Atom in Drug Design"
(2019) Rodriguez, J.B.; Gallo-Rodriguez, C. ChemMedChem. 14(2):190-216
"Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase"
(2018) Kashif, M.;Chacón-Vargas, K.F.;López-Cedillo, J.C. (
...
)Rivera, G. European Journal of Medicinal Chemistry. 156:252-268
"Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase"
(2018) Kashif, M.;Chacón-Vargas, K.F.;López-Cedillo, J.C. (
...
)Rivera, G. European Journal of Medicinal Chemistry. 156:252-268
"Studies of 4-arylthiazolylhydrazones derived from 1-indanones as Trypanosoma cruzi squalene epoxidase inhibitors by molecular simulations"
(2018) Noguera, G.J.; Fabian, L.E.; Lombardo, E.; Finkielsztein, L.M. Organic and Biomolecular Chemistry. 16(44):8525-8536
"Studies of 4-arylthiazolylhydrazones derived from 1-indanones as Trypanosoma cruzi squalene epoxidase inhibitors by molecular simulations"
(2018) Noguera, G.J.; Fabian, L.E.; Lombardo, E.; Finkielsztein, L.M. Organic and Biomolecular Chemistry. 16(44):8525-8536
"A Minimalist Approach to the Design of Complexity-Enriched Bioactive Small Molecules: Discovery of Phenanthrenoid Mimics as Antiproliferative Agents"
(2018) Alonso, F.;Quezada, M.J.;Gola, G.F. (
...
)Ramírez, J.A. ChemMedChem. 13(16):1732-1740
"Solvents to fragments to drugs: MD applications in drug design"
(2018) Defelipe, L.A.;Arcon, J.P.;Modenutti, C.P. (
...
)Barril, X. Molecules. 23(12)
"Solvents to fragments to drugs: MD applications in drug design"
(2018) Defelipe, L.A.;Arcon, J.P.;Modenutti, C.P. (
...
)Barril, X. Molecules. 23(12)
"Solvents to fragments to drugs: MD applications in drug design"
(2018) Defelipe, L.A.;Arcon, J.P.;Modenutti, C.P. (
...
)Barril, X. Molecules. 23(12)
"Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation"
(2017) Chao, M.N.;Storey, M.;Li, C. (
...
)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 25(24):6435-6449
"Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015)"
(2016) Rodriguez, J.B.; Falcone, B.N.; Szajnman, S.H. Expert Opinion on Therapeutic Patents. 26(9):993-1015
"Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015)"
(2016) Rodriguez, J.B.; Falcone, B.N.; Szajnman, S.H. Expert Opinion on Therapeutic Patents. 26(9):993-1015
"WC-9 a lead drug with great prospects for American trypanosomiasis and toxoplasmosis"
(2016) Rodriguez, J.B. Mini-Reviews in Medicinal Chemistry. 16(15):1195-1200
"WC-9 a lead drug with great prospects for American trypanosomiasis and toxoplasmosis"
(2016) Rodriguez, J.B. Mini-Reviews in Medicinal Chemistry. 16(15):1195-1200
"Signaling cascades transmit information downstream and upstream but unlikely simultaneously"
(2016) Catozzi, S.; Di-Bella, J.P.; Ventura, A.C.; Sepulchre, J.-A. BMC Systems Biology. 10(1)
"Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase"
(2016) Rodriguez, J.B.; Falcone, B.N.; Szajnman, S.H. Expert Opinion on Drug Discovery. 11(3):307-320
"Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase"
(2016) Rodriguez, J.B.; Falcone, B.N.; Szajnman, S.H. Expert Opinion on Drug Discovery. 11(3):307-320
"Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii"
(2016) Chao, M.N.;Li, C.;Storey, M. (
...
)Rodriguez, J.B. ChemMedChem. 11(24):2690-2702
"Anti-hemagglutinin antibody derived lead peptides for inhibitors of influenza virus binding"
(2016) Memczak, H.;Lauster, D.;Kar, P. (
...
)Stöcklein, W.F.M. PLoS ONE. 11(7)
"External guide sequence technology: A path to development of novel antimicrobial therapeutics"
(2015) Davies-Sala, C.;Soler-Bistué, A.;Bonomo, R.A. (
...
)Tolmasky, M.E. Annals of the New York Academy of Sciences. 1354(1):98-110
"WATCLUST: A tool for improving the design of drugs based on protein-water interactions"
(2015) López, E.D.;Arcon, J.P.;Gauto, D.F. (
...
)Turjanski, A.G. Bioinformatics. 31(22):3697-3699
"WATCLUST: A tool for improving the design of drugs based on protein-water interactions"
(2015) López, E.D.;Arcon, J.P.;Gauto, D.F. (
...
)Turjanski, A.G. Bioinformatics. 31(22):3697-3699
"Phosphatidylinositol kinase activities in Trypanosoma cruzi epimastigotes"
(2015) Gimenez, A.M.;Gesumaría, M.C.;Schoijet, A.C. (
...
)Machado, E.E. Molecular and Biochemical Parasitology. 203(1-2):14-24
"Phosphatidylinositol kinase activities in Trypanosoma cruzi epimastigotes"
(2015) Gimenez, A.M.;Gesumaría, M.C.;Schoijet, A.C. (
...
)Machado, E.E. Molecular and Biochemical Parasitology. 203(1-2):14-24
"Synthesis of D -galactofuranose-containing molecules: Design of galactofuranosyl acceptors"
(2014) Marino, C.; Baldoni, L. ChemBioChem. 15(2):189-204
"Synthesis of D -galactofuranose-containing molecules: Design of galactofuranosyl acceptors"
(2014) Marino, C.; Baldoni, L. ChemBioChem. 15(2):189-204
"Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines"
(2014) Cardama, G.A.;Comin, M.J.;Hornos, L. (
...
)Menna, P.L. Anti-Cancer Agents in Medicinal Chemistry. 14(6):840-851
"Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines"
(2014) Cardama, G.A.;Comin, M.J.;Hornos, L. (
...
)Menna, P.L. Anti-Cancer Agents in Medicinal Chemistry. 14(6):840-851
"Acrylic bone cements: The role of nanotechnology in improving osteointegration and tunable mechanical properties"
(2014) Lissarrague, M.H.; Fascio, M.L.; Goyanes, S.; D'Accorso, N.B. Journal of Biomedical Nanotechnology. 10(12):3536-3557
"Acrylic bone cements: The role of nanotechnology in improving osteointegration and tunable mechanical properties"
(2014) Lissarrague, M.H.; Fascio, M.L.; Goyanes, S.; D'Accorso, N.B. Journal of Biomedical Nanotechnology. 10(12):3536-3557
"New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase"
(2014) Ferrer-Casal, M.;Li, C.;Galizzi, M. (
...
)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 22(1):398-405
"Synthesis of D-galactofuranose-containing molecules: design of galactofuranosyl acceptors."
(2014) Marino, C.; Baldoni, L. Chembiochem : a European journal of chemical biology. 15(2):188-204
"Synthesis of D-galactofuranose-containing molecules: design of galactofuranosyl acceptors."
(2014) Marino, C.; Baldoni, L. Chembiochem : a European journal of chemical biology. 15(2):188-204
"Antiprotozoan lead discovery by aligning dry and wet screening: Prediction, synthesis, and biological assay of novel quinoxalinones"
(2014) Martins Alho, M.A.;Marrero-Ponce, Y.;Barigye, S.J. (
...
)Arán, V.J. Bioorganic and Medicinal Chemistry. 22(5):1568-1585
"Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents"
(2013) Recher, M.;Barboza, A.P.;Li, Z.-H. (
...
)Rodriguez, J.B. European Journal of Medicinal Chemistry. 60:431-440
"Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents"
(2013) Recher, M.;Barboza, A.P.;Li, Z.-H. (
...
)Rodriguez, J.B. European Journal of Medicinal Chemistry. 60:431-440
"Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents"
(2013) Elicio, P.D.;Chao, M.N.;Galizzi, M. (
...
)Rodriguez, J.B. European Journal of Medicinal Chemistry. 69:480-489
"Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents"
(2013) Elicio, P.D.;Chao, M.N.;Galizzi, M. (
...
)Rodriguez, J.B. European Journal of Medicinal Chemistry. 69:480-489
"Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of trypanosoma cruzi farnesyl diphosphate synthase"
(2012) Aripirala, S.;Szajnman, S.H.;Jakoncic, J. (
...
)Amzel, L.M. Journal of Medicinal Chemistry. 55(14):6445-6454
"Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of trypanosoma cruzi farnesyl diphosphate synthase"
(2012) Aripirala, S.;Szajnman, S.H.;Jakoncic, J. (
...
)Amzel, L.M. Journal of Medicinal Chemistry. 55(14):6445-6454
"Inhibition of Cell Division Induced by External Guide Sequences (EGS Technology) Targeting ftsZ"
(2012) Sala, C.D.;Soler-Bistué, A.J.C.;Korprapun, L. (
...
)Tolmasky, M.E. PLoS ONE. 7(10)
"A natural antiviral and immunomodulatory compound with antiangiogenic properties"
(2012) Bueno, C.A.; Lombardi, M.G.; Sales, M.E.; Alché, L.E. Microvascular Research. 84(3):235-241
"Synthesis of steroidal quinones and hydroquinones from bile acids by Barton radical decarboxylation and benzoquinone addition. Studies on their cytotoxic and antifungal activities"
(2012) Siless, G.E.;Knott, M.E.;Derita, M.G. (
...
)Palermo, J.A. Steroids. 77(1-2):45-51
"New antibacterials for the treatment of toxoplasmosis; A patent review"
(2012) Rodriguez, J.B.; Szajnman, S.H. Expert Opinion on Therapeutic Patents. 22(3):311-333
"1,2,4-Triazole d-ribose derivatives: Design, synthesis and antitumoral evaluation"
(2012) Avanzo, R.E.;Anesini, C.;Fascio, M.L. (
...
)D'Accorso, N.B. European Journal of Medicinal Chemistry. 47(1):104-110
"1,2,4-Triazole d-ribose derivatives: Design, synthesis and antitumoral evaluation"
(2012) Avanzo, R.E.;Anesini, C.;Fascio, M.L. (
...
)D'Accorso, N.B. European Journal of Medicinal Chemistry. 47(1):104-110
"Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation"
(2011) Copsel, S.;Garcia, C.;Diez, F. (
...
)Davio, C. Journal of Biological Chemistry. 286(9):6979-6988
"Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52)"
(2011) Sivils, J.C.; Storer, C.L.; Galigniana, M.D.; Cox, M.B. Current Opinion in Pharmacology. 11(4):314-319
"Widely differing photochemical behavior in related octahedral {Ru-NO} 6 compounds: Intramolecular redox isomerism of the excited state controlling the photodelivery of NO"
(2010) De Candia, A.G.; Marcolongo, J.P.; Etchenique, R.; Slep, L.D. Inorganic Chemistry. 49(15):6925-6930
"Widely differing photochemical behavior in related octahedral {Ru-NO} 6 compounds: Intramolecular redox isomerism of the excited state controlling the photodelivery of NO"
(2010) De Candia, A.G.; Marcolongo, J.P.; Etchenique, R.; Slep, L.D. Inorganic Chemistry. 49(15):6925-6930
"The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target?"
(2009) Elgoyhen, A.B.; Katz, E.; Fuchs, P.A. Biochemical Pharmacology. 78(7):712-719
"Synthesis and evaluation of 1,1′-hydrocarbylenebis(indazol-3-ols) as potential antimalarial drugs"
(2009) Alho, M.M.;García-Sánchez, R.N.;Nogal-Ruiz, J.J. (
...
)Arán, V.J. ChemMedChem. 4(1):78-87
"Synthesis of 9-β-d-arabinofuranosylguanine by combined use of two whole cell biocatalysts"
(2009) Médici, R.; Iribarren, A.M.; Lewkowicz, E.S. Bioorganic and Medicinal Chemistry Letters. 19(15):4210-4212
"Trapping and characterization of a reaction intermediate in carbapenem hydrolysis by B. cereus metallo-β-lactamase"
(2008) Tioni, M.F.;Llarrull, L.I.;Poeylaut-Palena, A.A. (
...
)Vila, A.J. Journal of the American Chemical Society. 130(47):15852-15863
"Functional activation by central monoamines of human dopamine D4 receptor polymorphic variants coupled to GIRK channels in Xenopus oocytes"
(2007) Wedemeyer, C.;Goutman, J.D.;Avale, M.E. (
...
)Calvo, D.J. European Journal of Pharmacology. 562(3):165-173
"Zn finger containing proteins as targets for the control of viral infections"
(2007) García, C.C.; Damonte, E.B. Infectious Disorders - Drug Targets. 7(3):204-212
"Zn finger containing proteins as targets for the control of viral infections"
(2007) García, C.C.; Damonte, E.B. Infectious Disorders - Drug Targets. 7(3):204-212
"An insight on targets and patented drugs for chemotherapy of chagas disease"
(2007) Duschak, V.G.; Couto, A.S. Recent Patents on Anti-Infective Drug Discovery. 2(1):19-51
"Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation"
(2007) Liñares, G.G.;Gismondi, S.;Codesido, N.O. (
...
)Rodriguez, J.B. Bioorganic and Medicinal Chemistry Letters. 17(18):5068-5071
"Current status and progress made in malaria chemotherapy"
(2007) Liñares, G.E.G.; Rodriguez, J.B. Current Medicinal Chemistry. 14(3):289-314
"Progresses in the field of drug design to combat tropical protozoan parasitic diseases"
(2006) García Liñares, G.E.; Ravaschino, E.L.; Rodriguez, J.B. Current Medicinal Chemistry. 13(3):335-360
"Progresses in the field of drug design to combat tropical protozoan parasitic diseases"
(2006) García Liñares, G.E.; Ravaschino, E.L.; Rodriguez, J.B. Current Medicinal Chemistry. 13(3):335-360
"Progresses in the field of drug design to combat tropical protozoan parasitic diseases"
(2006) García Liñares, G.E.; Ravaschino, E.L.; Rodriguez, J.B. Current Medicinal Chemistry. 13(3):335-360
"Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis"
(2006) Ravaschino, E.L.; Docampo, R.; Rodriguez, J.B. Journal of Medicinal Chemistry. 49(1):426-435
"Design, synthesis, and biological evaluation of phosphinopeptides against Trypanosoma cruzi targeting trypanothione biosynthesis"
(2006) Ravaschino, E.L.; Docampo, R.; Rodriguez, J.B. Journal of Medicinal Chemistry. 49(1):426-435
"Batch-to-batch consistency of human-derived gonadotrophin preparations compared with recombinant preparations"
(2005) Wolfenson, C.;Groisman, J.;Couto, A.S. (
...
)Jespersen, S. Reproductive BioMedicine Online. 10(4):442-454
"Activity and stability of hammerhead ribozymes containing 2′-C-methyluridine: A new RNA mimic"
(2005) Gallo, M.; Far, R.K.-K.; Sczakiel, G.; Iribarren, A.M. Chemistry and Biodiversity. 2(2):198-204
"Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi"
(2002) Elhalem, E.;Bailey, B.N.;Docampo, R. (
...
)Rodriguez, J.B. Journal of Medicinal Chemistry. 45(18):3984-3999
"Specific molecular targets to control tropical diseases"
(2001) Rodriguez, J.B. Current Pharmaceutical Design. 7(12):1105-1116
"Specific molecular targets to control tropical diseases"
(2001) Rodriguez, J.B. Current Pharmaceutical Design. 7(12):1105-1116
"Glycoinositolphospholipids, free and as anchors of proteins, in trypanosoma"
(2001) de Lederkremer, R.M.; Bertello, L.E. Current Pharmaceutical Design. 7(12):1165-1179
"Design and synthesis of aryloxyethyl thiocyanate derivatives as potent inhibitors of Trypanosoma cruzi proliferation"
(2000) Szajnman, S.H.;Yan, W.;Bailey, B.N. (
...
)Rodriguez, J.B. Journal of Medicinal Chemistry. 43(9):1826-1840
"Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)"
(1997) Schvartzapel, A.J.;Zhong, L.;Docampo, R. (
...
)Gros, E.G. Journal of Medicinal Chemistry. 40(15):2314-2322
"Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)"
(1997) Schvartzapel, A.J.;Zhong, L.;Docampo, R. (
...
)Gros, E.G. Journal of Medicinal Chemistry. 40(15):2314-2322
"Design, synthesis, and anti‐ Trypanosoma cruzi evaluation of a new class of cell‐growth inhibitors structurally related to Fenoxycarb"
(1995) Schvartzapel, A.J.;Fichera, L.;Esteva, M. (
...
)Gros, E.G. Helvetica Chimica Acta. 78(5):1207-1214
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