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drug potency
40
"Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase" (2016) Rodriguez, J.B.; Falcone, B.N.; Szajnman, S.H. Expert Opinion on Drug Discovery. 11(3):307-320
"The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates" (2016) Pujol, C.A.;Damonte, E.B.;Turjan, J. (...)Capek, P. International Journal of Biological Macromolecules. 87:195-200
"Synergistic Antiproliferative Effects of a New Cucurbitacin B Derivative and Chemotherapy Drugs on Lung Cancer Cell Line A549" (2015) Marostica, L.L.;Silva, I.T.;Kratz, J.M. (...)Simões, C.M.O. Chemical Research in Toxicology. 28(10):1949-1960
"New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase" (2014) Ferrer-Casal, M.;Li, C.;Galizzi, M. (...)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 22(1):398-405
"Preparation, anticholinesterase activity and molecular docking of new lupane derivatives" (2014) Castro, M.J.;Richmond, V.;Romero, C. (...)Murray, A.P. Bioorganic and Medicinal Chemistry. 22(13):3341-3350
"Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative" (2012) Sepúlveda, C.S.;García, C.C.;Fascio, M.L. (...)Damonte, E.B. Antiviral Research. 93(1):16-22
"Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides" (2012) Pujol, C.A.; Ray, S.; Ray, B.; Damonte, E.B. International Journal of Biological Macromolecules. 51(4):412-416
"2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase" (2012) Rodrígues-Poveda, C.A.; González-Pacanowska, D.; Szajnman, S.H.; Rodríguez, J.B. Antimicrobial Agents and Chemotherapy. 56(8):4483-4486
"Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-alzheimer agents" (2010) Galdeano, C.;Viayna, E.;Arroyo, P. (...)Luque, F.J. Current Pharmaceutical Design. 16(25):2818-2836
"Alpha9 nicotinic acetylcholine receptors and the treatment of pain" (2009) McIntosh, J.M.;Absalom, N.;Chebib, M. (...)Vincler, M. Biochemical Pharmacology. 78(7):693-702
"Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase" (2008) Szajnman, S.H.;García Liñares, G.E.;Li, Z.-H. (...)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 16(6):3283-3290
"Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica" (2007) Mandal, P.;Mateu, C.G.;Chattopadhyay, K. (...)Ray, B. Antiviral Chemistry and Chemotherapy. 18(3):153-162
"Inhibition of the α9α10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-d-aspartate receptors" (2007) Plazas, P.V.;Savino, J.;Kracun, S. (...)Elgoyhen, A.B. European Journal of Pharmacology. 566(1-3):11-19
"Current status and progress made in malaria chemotherapy" (2007) Liñares, G.E.G.; Rodriguez, J.B. Current Medicinal Chemistry. 14(3):289-314
"Effects of quinine, quinidine, and chloroquine on α9α10 nicotinic cholinergic receptors" (2005) Ballestero, J.A.;Plazas, P.V.;Kracun, S. (...)Elgoyhen, A.B. Molecular Pharmacology. 68(3):822-829
"Structural determinants of efficacy at A3 adenosine receptors: Modification of the ribose moiety" (2004) Gao, Z.-G.;Jeong, L.S.;Moon, H.R. (...)Jacobson, K.A. Biochemical Pharmacology. 67(5):893-901
"Sulfated seaweed polysaccharides as antiviral agents" (2004) Damonte, E.B.; Matulewicz, M.C.; Cerezo, A.S. Current Medicinal Chemistry. 11(18):2399-2419
"Progesterone treatment reduces NADPH-diaphorase/nitric oxide synthase in Wobbler mouse motoneuron disease" (2004) González Deniselle, M.C.;Garay, L.;López-Costa, J.J. (...)De Nicola, A.F. Brain Research. 1014(1-2):71-79
"Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase" (2003) Szajnman, S.H.;Montalvetti, A.;Wang, Y. (...)Rodriguez, J.B. Bioorganic and Medicinal Chemistry Letters. 13(19):3231-3235
"Virucidal Activity of Essential Oils from Aromatic Plants of San Luis, Argentina" (2003) García, C.C.;Talarico, L.;Almeida, N. (...)Damonte, E.B. Phytotherapy Research. 17(9):1073-1075
"Functional expression and properties of a nicotinic α9/5-HT3 A chimeric receptor" (2003) Verbitsky, M.; Plazas, P.V.; Elgoyhen, A.B. NeuroReport. 14(15):1931-1934
"Direct interaction of serotonin type 3 receptor ligands with recombinant and native α9α10-containing nicotinic cholinergic receptors" (2003) Rothlin, C.V.;Lioudyno, M.I.;Silbering, A.F. (...)Elgoyhen, A.B. Molecular Pharmacology. 63(5):1067-1074
"Induction of quinone reductase by withanolides" (2002) Misico, R.I.;Song, L.L.;Veleiro, A.S. (...)Pezzuto, J.M. Journal of Natural Products. 65(5):677-680
"ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum" (2002) Mongelli, E.;Pomilio, A.B.;Bustamante Sánchez, J. (...)Martínez Massanet, G. Phytotherapy Research. 16(4):387-388
"Novel DL-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus" (2002) Pujol, C.A.;Estevez, J.M.;Carlucci, M.J. (...)Damonte, E.B. Antiviral Chemistry and Chemotherapy. 13(2):83-89
"Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi" (2002) Elhalem, E.;Bailey, B.N.;Docampo, R. (...)Rodriguez, J.B. Journal of Medicinal Chemistry. 45(18):3984-3999
"Pharmacophore model for antiepileptic drugs acting on sodium channels" (2001) Tasso, S.M.; Bruno-Blanch, L.E.; Estiú, G.L. Journal of Molecular Modeling. 7(7):231-239
"Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi" (2001) Szajnman, S.H.; Bailey, B.N.; Docampo, R.; Rodriguez, J.B. Bioorganic and Medicinal Chemistry Letters. 11(6):789-792
"Acyclic analogues of deoxyadenosine 3',5'-bisphosphates as P2Y 1 receptor antagonists" (2000) Kim, Y.-C.;Gallo-Rodriguez, C.;Jang, S.-Y. (...)Jacobson, K.A. Journal of Medicinal Chemistry. 43(4):746-755
"Design and synthesis of aryloxyethyl thiocyanate derivatives as potent inhibitors of Trypanosoma cruzi proliferation" (2000) Szajnman, S.H.;Yan, W.;Bailey, B.N. (...)Rodriguez, J.B. Journal of Medicinal Chemistry. 43(9):1826-1840
"6-Chloro-3'-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activity" (2000) Viola, H.;Wolfman, C.;Marder, M. (...)Medina, J.H. Pharmacology Biochemistry and Behavior. 65(2):313-320
"Interactions that define the alkylamine side-chain conformation in phenylalkylamine hallucinogens: An ab initio study" (2000) Taurian, O.E.; Contreras, R.H. Journal of Molecular Structure: THEOCHEM. 504(1-3):119-126
"Mechanism of action of the potent sodium-retaining steroid 11,19- oxidoprogesterone" (2000) Galigniana, M.D.;Vicent, G.P.;Piwien-Pilipuk, G. (...)Lantos, C.P. Molecular Pharmacology. 58(1):58-70
"Nerve growth factor and retinoic acid inhibit proliferation and invasion in thyroid tumor cells" (2000) Páez Pereda, M.;Missale, C.;Grübler, Y. (...)Stalla, G.K. Molecular and Cellular Endocrinology. 167(1-2):99-106
"Block of the α9 nicotinic receptor by ototoxic aminoglycosides" (2000) Rothlin, C.V.;Katz, E.;Verbitsky, M. (...)Elgoyhen, A.B. Neuropharmacology. 39(13):2525-2532
"Ayahoasca: An experimental psychosis that mirrors the transmethylation hypothesis of schizophrenia" (1999) Pomilio, A.B.;Vitale, A.A.;Ciprian-Ollivier, J. (...)Vázquez, G. Journal of Ethnopharmacology. 65(1):29-51