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enzyme inhibition
170
"Glycerol inhibition of melanin biosynthesis in the environmental Aeromonas salmonicida 34mel T"
(2019) Pavan, M.E.;Venero, E.S.;Egoburo, D.E. (
...
)Julia Pettinari, M. Applied Microbiology and Biotechnology. 103(4):1865-1876
"Synthesis, molecular docking and biological evaluation of novel phthaloyl derivatives of 3-amino-3-aryl propionic acids as inhibitors of Trypanosoma cruzi trans-sialidase"
(2018) Kashif, M.;Chacón-Vargas, K.F.;López-Cedillo, J.C. (
...
)Rivera, G. European Journal of Medicinal Chemistry. 156:252-268
"Expression of the mRNA stability regulator Tristetraprolin is required for lactation maintenance in the mouse mammary gland"
(2018) Goddio, M.V.;Gattelli, A.;Tocci, J.M. (
...
)Kordon, E.C. Oncotarget. 9(9):8278-8289
"Toxicokinetic and toxicodynamic studies of carbaryl alone or in binary mixtures with azinphos methyl in the freshwater gastropod Planorbarius corneus"
(2018) Cacciatore, L.C.; Verrengia Guerrero, N.R.; Cochón, A.C. Aquatic Toxicology. 199:276-284
"Effect of tamoxifen on the sphingolipid biosynthetic pathway in the different intraerythrocytic stages of the apicomplexa Plasmodium falciparum"
(2018) Piñero, T.A.;Landoni, M.;Duschak, V.G. (
...
)Couto, A.S. Biochemical and Biophysical Research Communications. 497(4):1082-1088
"Chronic expression of wild-type Ret receptor in the mammary gland induces luminal tumors that are sensitive to Ret inhibition"
(2018) Gattelli, A.;García Solá, M.E.;Roloff, T.C. (
...
)Hynes, N.E. Oncogene. 37(29):4046-4054
"Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction"
(2018) Lunardi, P.;Sachser, R.M.;Sierra, R.O. (
...
)de Oliveira Alvares, L. Molecular Neurobiology. 55(2):958-967
"Tankyrase inhibition regulates corpus luteum development and luteal function in gonadotropin-treated rats"
(2017) Accialini, P.;Irusta, G.;Bechis, A. (
...
)Tesone, M. Molecular Reproduction and Development. 84(8):719-730
"Tributyltin bioaccumulation and toxic effects in freshwater gastropods Pomacea canaliculata after a chronic exposure: field and laboratory studies"
(2017) Martínez, M.L.; Piol, M.N.; Sbarbati Nudelman, N.; Verrengia Guerrero, N.R. Ecotoxicology. 26(5):691-701
"An in vitro and in vivo evaluation of new potential trans-sialidase inhibitors of Trypanosoma cruzi predicted by a computational drug repositioning method"
(2017) Lara-Ramirez, E.E.;López-Cedillo, J.C.;Nogueda-Torres, B. (
...
)Rivera, G. European Journal of Medicinal Chemistry. 132:249-261
"Turning-off signaling by siglecs, selectins, and galectins: Chemical inhibition of glycan-dependent interactions in cancer"
(2016) Cagnoni, A.J.; Pérez Sáez, J.M.; Rabinovich, G.A.; Mariño, K.V. Frontiers in Oncology. 6(MAY)
"WC-9 a lead drug with great prospects for American trypanosomiasis and toxoplasmosis"
(2016) Rodriguez, J.B. Mini-Reviews in Medicinal Chemistry. 16(15):1195-1200
"In vitro and in vivo studies of cholinesterases and carboxylesterases in Planorbarius corneus exposed to a phosphorodithioate insecticide: Finding the most sensitive combination of enzymes, substrates, tissues and recovery capacity"
(2016) Otero, S.; Kristoff, G. Aquatic Toxicology. 180:186-195
"Revisiting direct electron transfer in nanostructured carbon laccase oxygen cathodes"
(2016) Adam, C.;Scodeller, P.;Grattieri, M. (
...
)Calvo, E.J. Bioelectrochemistry. 109:101-107
"Role of CREB on heme oxygenase-1 induction in adrenal cells: Involvement of the PI3K pathway"
(2016) Astort, F.;Repetto, E.M.;Rocha-Viegas, L. (
...
)Cymeryng, C.B. Journal of Molecular Endocrinology. 57(2):113-124
"Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase"
(2016) Rodriguez, J.B.; Falcone, B.N.; Szajnman, S.H. Expert Opinion on Drug Discovery. 11(3):307-320
"Synthetic stigmastanes with dual antiherpetic and immunomodulating activities inhibit ERK and Akt signaling pathways without binding to glucocorticoid receptors"
(2016) Michelini, F.M.;Bueno, C.A.;Molinari, A.M. (
...
)Ramírez, J.A. Biochimica et Biophysica Acta - General Subjects. 1860(1):129-139
"S-layer proteins from Lactobacillus sp. inhibit bacterial infection by blockage of DC-SIGN cell receptor"
(2016) Prado Acosta, M.; Ruzal, S.M.; Cordo, S.M. International Journal of Biological Macromolecules. 92:998-1005
"Reconsolidation-induced memory persistence: Participation of late phase hippocampal ERK activation"
(2016) Krawczyk, M.C.;Navarro, N.;Blake, M.G. (
...
)Boccia, M.M. Neurobiology of Learning and Memory. 133:79-88
"Synthesis of Enantiomeric Polyhydroxyalkylpyrrolidines from 1,3-Dipolar Cycloadducts. Evaluation as Inhibitors of a β-Galactofuranosidase"
(2016) Oliveira Udry, G.A.; Repetto, E.; Vega, D.R.; Varela, O. Journal of Organic Chemistry. 81(10):4179-4189
"miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga"
(2016) De Lella Ezcurra, A.L.;Bertolin, A.P.;Kim, K. (
...
)Wappner, P. PLoS Genetics. 12(5)
"Small molecules as anti-TNF drugs"
(2015) Richmond, V.;Michelini, F.M.;Bueno, C.A. (
...
)Ramírez, J.A. Current Medicinal Chemistry. 22(25):2920-2942
"Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation"
(2015) Krawczyk, M.C.;Blake, M.G.;Baratti, C.M. (
...
)Feld, M. Neuroscience. 294:227-237
"External guide sequence technology: A path to development of novel antimicrobial therapeutics"
(2015) Davies-Sala, C.;Soler-Bistué, A.;Bonomo, R.A. (
...
)Tolmasky, M.E. Annals of the New York Academy of Sciences. 1354(1):98-110
"Recovery study of cholinesterases and neurotoxic signs in the non-target freshwater invertebrate Chilina gibbosa after an acute exposure to an environmental concentration of azinphos-methyl"
(2015) Cossi, P.F.; Beverly, B.; Carlos, L.; Kristoff, G. Aquatic Toxicology. 167:248-256
"Synergistic Antiproliferative Effects of a New Cucurbitacin B Derivative and Chemotherapy Drugs on Lung Cancer Cell Line A549"
(2015) Marostica, L.L.;Silva, I.T.;Kratz, J.M. (
...
)Simões, C.M.O. Chemical Research in Toxicology. 28(10):1949-1960
"A bumpy road for RNA polymerase II"
(2015) Giono, L.E.; Kornblihtt, A.R. Nature Structural and Molecular Biology. 22(5):353-355
"Involvement of PI3K/Akt and p38 MAPK in the induction of COX-2 expression by bacterial lipopolysaccharide in murine adrenocortical cells"
(2014) Mercau, M.E.;Astort, F.;Giordanino, E.F. (
...
)Cymeryng, C.B. Molecular and Cellular Endocrinology. 384(1-2):43-51
"Resistance in cholinesterase activity after an acute and subchronic exposure to azinphos-methyl in the freshwater gastropod Biomphalaria straminea"
(2014) Bianco, K.;Otero, S.;Balazote Oliver, A. (
...
)Kristoff, G. Ecotoxicology and Environmental Safety. 109:85-92
"Synthesis and cholinesterase inhibition of cativic acid derivatives"
(2014) Alza, N.P.;Richmond, V.;Baier, C.J. (
...
)Murray, A.P. Bioorganic and Medicinal Chemistry. 22(15):3838-3849
"Regulatory volume increase and regulatory volume decrease responses in HL-1 atrial myocytes"
(2014) Cacace, V.I.;Finkelsteyn, A.G.;Tasso, L.M. (
...
)Fischbarg, J. Cellular Physiology and Biochemistry. 33(6):1745-1757
"How Slow RNA Polymerase II Elongation Favors Alternative Exon Skipping"
(2014) Dujardin, G.;Lafaille, C.;de la Mata, M. (
...
)Kornblihtt, A.R. Molecular Cell. 54(4):683-690
"The P0 protein encoded by cotton leafroll dwarf virus (CLRDV) inhibits local but not systemic RNA silencing"
(2014) Delfosse, V.C.;Agrofoglio, Y.C.;Casse, M.F. (
...
)Distéfano, A.J. Virus Research. 180:70-75
"Preparation, anticholinesterase activity and molecular docking of new lupane derivatives"
(2014) Castro, M.J.;Richmond, V.;Romero, C. (
...
)Murray, A.P. Bioorganic and Medicinal Chemistry. 22(13):3341-3350
"Acridones as antiviral agents: Synthesis, chemical and biological properties"
(2013) Sepúlveda, C.S.;Fascio, M.L.;García, C.C. (
...
)Damonte, E.B. Current Medicinal Chemistry. 20(19):2402-2414
"Synthesis of the (1→6)-linked thiodisaccharide of galactofuranose: Inhibitory activity against a β-galactofuranosidase"
(2013) Repetto, E.; Marino, C.; Varela, O. Bioorganic and Medicinal Chemistry. 21(11):3327-3333
"Synthesis of the (1→6)-linked thiodisaccharide of galactofuranose: Inhibitory activity against a β-galactofuranosidase"
(2013) Repetto, E.; Marino, C.; Varela, O. Bioorganic and Medicinal Chemistry. 21(11):3327-3333
"Cholinesterase and carboxylesterase inhibition in Planorbarius corneus exposed to binary mixtures of azinphos-methyl and chlorpyrifos"
(2013) Cacciatore, L.C.; Verrengia Guerrero, N.; Cochón, A.C. Aquatic Toxicology. 128-129:124-134
"Different effects of subchronic exposure to low concentrations of the organophosphate insecticide chlorpyrifos in a freshwater gastropod"
(2013) Rivadeneira, P.R.; Agrelo, M.; Otero, S.; Kristoff, G. Ecotoxicology and Environmental Safety. 90:82-88
"Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation"
(2013) Toneatto, J.;Guber, S.;Charó, N.L. (
...
)Piwien-Pilipuk, G. Journal of Cell Science. 126(23):5357-5368
"Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of trypanosoma cruzi farnesyl diphosphate synthase"
(2012) Aripirala, S.;Szajnman, S.H.;Jakoncic, J. (
...
)Amzel, L.M. Journal of Medicinal Chemistry. 55(14):6445-6454
"The Alternative Epac/cAMP Pathway and the MAPK Pathway Mediate hCG Induction of Leptin in Placental Cells"
(2012) Maymó, J.L.;Pérez Pérez, A.;Maskin, B. (
...
)Varone, C.L. PLoS ONE. 7(10)
"Influence of conformationally restricted pyrimidines on the activity of 10-23 DNAzymes"
(2012) Robaldo, L.;Izzo, F.;Dellafiore, M. (
...
)Iribarren, A.M. Bioorganic and Medicinal Chemistry. 20(8):2581-2586
"In vivo studies on inhibition and recovery of B-esterase activities in Biomphalaria glabrata exposed to azinphos-methyl: Analysis of enzyme, substrate and tissue dependence"
(2012) Kristoff, G.;Chiny Barrionuevo, D.;Cacciatore, L.C. (
...
)Cochón, A.C. Aquatic Toxicology. 112-113:19-26
"Binary mixtures of azinphos-methyl oxon and chlorpyrifos oxon produce in vitro synergistic cholinesterase inhibition in Planorbarius corneus"
(2012) Cacciatore, L.C.; Kristoff, G.; Verrengia Guerrero, N.R.; Cochón, A.C. Chemosphere. 88(4):450-458
"New antibacterials for the treatment of toxoplasmosis; A patent review"
(2012) Rodriguez, J.B.; Szajnman, S.H. Expert Opinion on Therapeutic Patents. 22(3):311-333
"Reconsolidation involves histone acetylation depending on the strength of the memory"
(2012) Federman, N.; Fustiñana, M.S.; Romano, A. Neuroscience. 219:145-156
"Melatonin inhibits glucocorticoid-dependent GR-TIF2 interaction in newborn hamster kidney (BHK) cells"
(2012) Presman, D.M.; Levi, V.; Pignataro, O.P.; Pecci, A. Molecular and Cellular Endocrinology. 349(2):214-221
"Differential Requirements in Endocytic Trafficking for Penetration of Dengue Virus"
(2012) Acosta, E.G.; Castilla, V.; Damonte, E.B. PLoS ONE. 7(9)
"E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation"
(2012) Carcagno, A.L.;Giono, L.E.;Marazita, M.C. (
...
)Cánepa, E.T. Molecular and Cellular Biochemistry. 366(1-2):123-129
"2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase"
(2012) Rodrígues-Poveda, C.A.; González-Pacanowska, D.; Szajnman, S.H.; Rodríguez, J.B. Antimicrobial Agents and Chemotherapy. 56(8):4483-4486
"Effect of bitter compounds on amylase secretion in murine submandibular glands: Signaling pathway mechanisms"
(2011) Dasso, M.;Pagotto, R.;Pignataro, O.P. (
...
)Sales, M.E. Biochimica et Biophysica Acta - General Subjects. 1810(12):1212-1219
"Synthesis and acetylcholinesterase inhibitory activity of 2β,3α-disulfoxy-5α-cholestan-6-one"
(2011) Richmond, V.; Santos, G.A.G.; Murray, A.P.; Maier, M.S. Steroids. 76(10-11):1160-1165
"Effects of the organophosphate insecticide azinphos-methyl on the reproduction and cholinesterase activity of Biomphalaria glabrata"
(2011) Kristoff, G.; Cacciatore, L.C.; Verrengia Guerrero, N.R.; Cochón, A.C. Chemosphere. 84(5):585-591
"Reconsolidation or extinction: Transcription factor switch in the determination of memory course after retrieval"
(2011) de la Fuente, V.; Freudenthal, R.; Romano, A. Journal of Neuroscience. 31(15):5562-5573
"Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1- bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase"
(2011) Rosso, V.S.;Szajnman, S.H.;Malayil, L. (
...
)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 19(7):2211-2217
"ALA-D and ALA-D reactivated as biomarkers of lead contamination in the fish Prochilodus lineatus"
(2010) Lombardi, P.E.; Peri, S.I.; Verrengia Guerrero, N.R. Ecotoxicology and Environmental Safety. 73(7):1704-1711
"17Beta-estradiol enhances leptin expression in human placental cells through genomic and nongenomic actions"
(2010) Gambino, Y.P.;Maymó, J.L.;Pérez-Pérez, A. (
...
)Varone, C.L. Biology of Reproduction. 83(1):42-51
"Mechanism of hCG-induced spermiation in the toad Rhinella arenarum (Amphibia, Anura)"
(2010) Volonteri, M.C.; Ceballos, N.R. General and Comparative Endocrinology. 169(3):197-202
"Synthesis of PEGylated lactose analogs for inhibition studies on T.cruzi trans-sialidase"
(2010) Giorgi, M.E.;Ratier, L.;Agusti, R. (
...
)De Lederkremer, R.M. Glycoconjugate Journal. 27(5):549-559
"Continuous nonradioactive method for screening trypanosomal transsialidase activity and its inhibitors"
(2010) Sartor, P.A.;Agusti, R.;Leguizamón, M.S. (
...
)de Lederkremer, R.M. Glycobiology. 20(8):982-990
"Inhibition of cholinesterases and carboxylesterases of two invertebrate species, Biomphalaria glabrata and Lumbriculus variegatus, by the carbamate pesticide carbaryl"
(2010) Kristoff, G.; Guerrero, N.R.V.; Cochón, A.C. Aquatic Toxicology. 96(2):115-123
"Triterpenoids with acetylcholinesterase inhibition from chuquiraga erinacea D. Don. subsp. erinacea (Asteraceae)"
(2010) Gurovic, M.S.V.;Castro, M.J.;Richmond, V. (
...
)Murray, A.P. Planta Medica. 76(6):607-610
"MAPK and PI3K activities are required for leptin stimulation of protein synthesis in human trophoblastic cells"
(2010) Pérez-Pérez, A.;Gambino, Y.;Maymó, J. (
...
)Sánchez-Margalet, V. Biochemical and Biophysical Research Communications. 396(4):956-960
"Abscisic acid (ABA) receptors: Light at the end of the tunnel"
(2010) Muschietti, J.; McCormick, S. F1000 Biology Reports. 2(1)
"Inhibitory effect of quercetin on matrix metalloproteinase 9 activity Molecular mechanism and structure-activity relationship of the flavonoid-enzyme interaction"
(2010) Saragusti, A.C.;Ortega, M.G.;Cabrera, J.L. (
...
)Chiabrando, G.A. European Journal of Pharmacology. 644(1-3):138-145
"Differential antiapoptotic effect of erythropoietin on undifferentiated and retinoic acid-differentiated SH-SY5Y cells"
(2010) Wenker, S.D.;Chamorro, M.E.;Vota, D.M. (
...
)Nesse, A.B. Journal of Cellular Biochemistry. 110(1):151-161
"Regulation of placental leptin expression by cyclic adenosine 5′-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways"
(2010) Maymó, J.L.;Pérez, A.P.;Dueñas, J.L. (
...
)Varone, C.L. Endocrinology. 151(8):3738-3751
"Erratum: The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway (Journal of Cell Science vol. 122 (2453-2463))"
(2009) Mukherjee, D.;Coon, B.G.;Edwards III, D.F. (
...
)Aguilar, R.C. Journal of Cell Science. 122(14)
"New lead compounds in the search for pure antiglucocorticoids and the dissociation of antiglucocorticoid effects"
(2009) Pecci, A.;Alvarez, L.D.;Veleiro, A.S. (
...
)Burton, G. Journal of Steroid Biochemistry and Molecular Biology. 113(3-5):155-162
"Participation of the phosphatidylinositol 3-kinase/Akt pathway in Junín virus replication in vitro"
(2009) Linero, F.N.; Scolaro, L.A. Virus Research. 145(1):166-170
"Thiodisaccharides with galactofuranose or arabinofuranose as terminal units: Synthesis and inhibitory activity of an exo β-d-galactofuranosidase"
(2009) Repetto, E.; Marino, C.; Laura Uhrig, M.; Varela, O. Bioorganic and Medicinal Chemistry. 17(7):2703-2711
"DNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation"
(2009) Muñoz, M.J.;Santangelo, M.S.P.;Paronetto, M.P. (
...
)Kornblihtt, A.R. Cell. 137(4):708-720
"High glucose-induced changes in steroid production in adrenal cells"
(2009) Astort, F.;Repetto, E.M.;Martínez Calejman, C. (
...
)Cymeryng, C.B. Diabetes/Metabolism Research and Reviews. 25(5):477-486
"Hexachlorobenzene treatment on hepatic mitochondrial function parameters and intracellular coproporphyrinogen oxidase location"
(2008) Sopena, Y.E.; Ferramola De Sancovich, A.M.; Sancovich, H.A. International Journal of Toxicology. 27(6):455-465
"Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase"
(2008) Szajnman, S.H.;García Liñares, G.E.;Li, Z.-H. (
...
)Rodriguez, J.B. Bioorganic and Medicinal Chemistry. 16(6):3283-3290
"A Trypanosoma cruzi phosphatidylinositol 3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis"
(2008) Schoijet, A.C.;Miranda, K.;Girard-Dias, W. (
...
)Alonso, G.D. Journal of Biological Chemistry. 283(46):31541-31550
"A Trypanosoma cruzi phosphatidylinositol 3-kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis"
(2008) Schoijet, A.C.;Miranda, K.;Girard-Dias, W. (
...
)Alonso, G.D. Journal of Biological Chemistry. 283(46):31541-31550
"Rat caltrin protein modulates the acrosomal exocytosis during sperm capacitation"
(2008) Dematteis, A.;Miranda, S.D.;Novella, M.L. (
...
)Coronel, C.E. Biology of Reproduction. 79(3):493-500
"The trans-sialidase from Trypanosoma cruzi efficiently transfers α-(2→3)-linked N-glycolylneuraminic acid to terminal β-galactosyl units"
(2007) Agustí, R.; Giorgi, M.E.; de Lederkremer, R.M. Carbohydrate Research. 342(16):2465-2469
"Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: Involvement of both signaling systems in the modulation of ACTH-dependent steroid production"
(2007) Grion, N.;Repetto, E.M.;Pomeraniec, Y. (
...
)Cymeryng, C.B. Journal of Endocrinology. 194(1):11-20
"Inhibition of cytochrome P-450 C17 enzyme by a GnRH agonist in ovarian follicles from gonadotropin-stimulated rats"
(2007) Irusta, G.; Parborell, F.; Tesone, M. American Journal of Physiology - Endocrinology and Metabolism. 292(5):E1456-E1464
"Differential recruitment of tetratricorpeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity"
(2007) Gallo, L.I.; Ghini, A.A.; Pilipuk, G.P.; Galigniana, M.D. Biochemistry. 46(49):14044-14057
"Preliminary characterization of bacteriocins from Lactococcus lactis, Enterococcus faecium and Enterococcus mundtii strains isolated from turbot (Psetta maxima)"
(2006) Campos, C.A.;Rodríguez, O.;Calo-Mata, P. (
...
)Barros-Velázquez, J. Food Research International. 39(3):356-364
"Inhibition of heme oxygenase-1 interferes with the transforming activity of the Kaposi sarcoma herpesvirus-encoded G protein-coupled receptor"
(2006) Marinissen, M.J.;Tanos, T.;Bolós, M. (
...
)Cuadrado, A. Journal of Biological Chemistry. 281(16):11332-11346
"Cyclooxygenase-2 and prostaglandin F2α in syrian hamster leydig cells: inhibitory role on luteinizing hormone/human chorionic gonadotropin-stimulated testosterone production"
(2006) Frungieri, M.B.;Gonzalez-Calvar, S.I.;Parborell, F. (
...
)Calandra, R.S. Endocrinology. 147(9):4476-4485
"Inhibition of cholinesterase activity by azinphos-methyl in two freshwater invertebrates: Biomphalaria glabrata and Lumbriculus variegatus"
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